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Biomedical subjects

M R Cohen

Publications and source records attributed to M R Cohen.

At least 127 records · Page 7Linked to original sources
PubMed1990

TRH attenuates scopolamine-induced memory impairment in humans.

The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo was administered intravenously (IV) to normal controls pretreated with scopolamine (0.5-0.75 mg IV), a centrally active muscarinic antagonist, which has been used to model aspects of the memory impairment of normal aging and of dementia. Compared to placebo, TRH markedly attenuated scopolamine-induced impairment of some measures of memory, most notably on a selective reminding task. This cognitive study is the first in humans to suggest a neuromodulatory effect of a peptide on the cholinergic system, and suggests a facilitatory role for TRH in human memory processes.

Adult↗
PubMed1990

Cultured skin fibroblasts in schizophrenia: quantitative two-dimensional electrophoresis.

Recent developments in the standardization and commercial availability of quantitative high resolution two-dimensional electrophoresis make feasible the systematic search for protein alterations characteristic of psychiatric disorders. To avoid the effects of such variables as drug intake or diet on quantitative protein makeup that might obscure its relationship to diagnosis, the investigators studied cultured fibroblasts derived from the skin biopsies of psychiatric patients. Although the method was able to resolve human fibroblast protein mixtures into 1,125 spots, no significant deviation in the quantitation of any individual spot was found to characterize the fibroblasts of patients with schizophrenia.

Adult↗
PubMed1990

A system for monitoring and dispensing epoetin.

This article describes one hospital's system of providing epoetin therapy for patients with renal failure undergoing dialysis. Nurses complete a drug dosing worksheet which alerts pharmacists to the need for both epoetin and iron dextran doses. The patient's weight and hematocrit are included on the form as are initial dose calculations made by the nurse. Pharmacists use this information for patient monitoring and double checking dose calculations. Then individually packaged unit dose injectables are prepared by pharmacy for use by nurses. A drug use evaluation for epoetin assures that appropriate use criteria are fulfilled when epoetin is used.

Erythropoietin↗