Biomedical subjects
Publications and source records attributed to M R Adams.
A pelvic mass in an aged, male talapoin monkey, believed to be of Müllerian duct origin, is described. Histologically, the mass was composed of smooth muscle cells and glandular epithelium, although the typical uterine organization of these tissues was not observed. The remainder of the genital system was that of a normal male primate.
This paper focuses upon and discusses some common problems in the design and conduct of various types of stuttering research. Apparent problems are dealt with under the following headings: (1) circular definitions of hypothetical constructs, (2) operational definitions of stuttering that lack denotative specificity, (3) research designs based on invalid assumptions about stuttering, and (4) omitted or inadequate measurement of speech rate in operant studies of stuttering. In each of these sections, a problem is identified and then some suggestions are offered for resolving it. This article pertains to research that underlies clinical management, and some implications for clinicians are drawn.
This study tested the hypothesis that stutterers have difficulty initiating and terminating phonation independent of the acts of running speech and stuttering. Ten young adult stutterers served as the experimental group. They were matched as a group for age and sex with 10 normal speakers. Subjects from both groups were tested individually. The experimental task required that subjects start and stop phonation as quickly as possible upon hearing each member of a seried of 1000-Hz pure tones appear and then disappear. Subjects' vocalizations were permanently recorded on an optical oscillograph. Results showed that both groups improved (shortened) their voice initiation and termination times from the beginning to the end of the experiment. Typically, however, the stutterers were significantly slower than the control subjects on most of the temporal measures.
This study was conducted to determine if the reduction of stuttering typically observed during singing is associated with altered vocalization or the familiarity of the melody and lyrics of the song sung by the stutterer, or both. Subjects were eight adult male stutterers. Prior to testing, each of these individuals demonstrated that he knew the melody and lyrics of a well-known song from memory. Subsequently, subjects were asked to read these lyrics aloud and then sing them. Next, subjects had to read aloud and then sing a set of unfamiliar lyrics to the conventional melody of the same song. The stutterers' reading and singing performances were audiotaped. The dependent measures of utterance duration and stuttering frequency were extracted from the tapes. Results showed that subjects' utterance durations were significantly longer during singing than reading. The main effects of singing and familiarity were both associated with significant reductions in stuttering frequency. The greatest decrement in stuttering occurred in the condition where subjects sang the familiar melody and lyrics. These findings were interpreted to mean that changes in vocalization cannot account for all of the decrease in stuttering that occurs during singing. During song, the familiarity of the melody and lyrics being produced may also affect stuttering frequency.
The Subhuman Primate Pregnancy Test kit was used for diagnosis of pregnancy in 17 marmosets. This hemagglutination inhibition test for urinary chorionic gonadotropin accurately indicated conception by positive responses in 72 and 76 specimens collected between the 4th and 10th wk following the estimated time of fertilization. The rate of false positive results did not exceed 1%. A radioimmunoassay system was used to quantify chorionic gonadotropin concentrations in urine. Detectable levels were present by the 2nd week of pregnancy. Peak chorionic gonadotropin levels were found between the 7th to 9th wk after conception. Chorionic gonadotropin excretion rates declined to undetectable levels during the final month of gestation.
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Reproductive performances of wild-caught and laboratory-born marmosets maintained in a paired-cage system were summarized. Wild-caught, white-lipped (WL) marmosets (Saguinus fuscicollis, S nigricollis) averaged 2.6 live births per pair per yr compared with 1.6 for cotton-topped (CT) marmosets (S oedipus); S fuscicollis illigeri pairs were the best producers. Of first and second generation laboratory-born animals, crossbred or hybrid WL pairs were the best producers; first generation pairs averaged 2.7 live births per pair per yr, comparable to the production of wild-caught WL pairs. In contrast, laboratory-born Sf illigeri pairs produced only 0.8 live births per pair per yr. No significant differences in reproductive performance were observed between first generation outbred vs inbred and between parent-reared vs hand-reared pairs. Based on limited data, the reproductive capabilities of wild-caught and laboratory-born Callithrix jacchus appeared superior to both WL and CT marmosets. Ten examples of marmoset models in biomedical research were discussed briefly.
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Diabetes mellitus is an important risk factor for both macrovascular and cardiac disease in humans. The availability of a novel intravenous ultrasound probe allows detailed interrogation of a large proportion of the vasculature, as well as the heart, during the same examination. Six male baboons (Papio hamadryas) with Type 1 diabetes and known microangiopathy, and six control animals were studied. Vascular structure in the major large arteries and cardiac function were studied using transvenous ultrasound introduced via the right femoral vein and positioned under fluoroscopy. All arteries were examined for atherosclerotic plaque and for presence of increased intima-media thickness (IMT). Left ventricular function was assessed at rest and following infusions of dobutamine (positive inotrope) and esmolol (negative inotrope). The procedure was performed safely and successfully in all cases. No atherosclerotic plaque was seen in either diabetic or normal baboons. There was no difference in the aortic IMT (0.38+/-0.04 vs. 0.37+/-0.05 mm, normal vs. diabetic, P=NS) or in doppler flow in the renal or iliac arteries between diabetic and normal baboons. Left ventricular wall thickness and systolic tissue velocity were similar in the two groups at rest (6.9+/-2.5 vs. 6.2+/-1.4 cm/s, normal vs. diabetic, P=NS), after dobutamine (15.5+/-2.2 vs. 12.7+/-3.9 cm/s, normal vs. diabetic, P=NS), and after esmolol (4.3+/-1.0 vs. 5.6+/-1.0 cm/s, normal vs. diabetic, P=NS). In a high primate model of diabetes with microangiopathy, the presence of hyperglycemia for 7 years per se does not produce abnormalities of macrovascular or cardiac structure.