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Biomedical subjects

M Quintana

Publications and source records attributed to M Quintana.

At least 55 records · Page 3Linked to original sources
PubMed1995

ST-segment depression on ambulatory electrocardiography in the early in-hospital period after acute myocardial infarction predicts early and late mortality: a short-term and a 3-year follow-up study.

A surveillance study was conducted to determine the in-hospital and long-term prognostic value of ST-segment depression assessed by ambulatory electrocardiographic monitoring (AEM) during the early in-hospital period after acute myocardial infarction (AMI). ST-segment depression (STD) was determined by computer analysis of 24-h ECG tapes as a horizontal or downsloping change in ST level by > 0.1 mV from the reference base line. The ST level was measured 80 ms after the J point of all normally conducted complexes for > or = 1 min. All computer-detected ST events were verified by one trained reader. Tapes corresponding to 74 patients were analyzed. In addition, 23 tapes corresponding to age- and gender-matched controls were also analyzed. Patients were divided into two groups: 22 patients (30%) showed STD (Group A), and 52 patients (70%) had no episode of STD (Group B). Among controls, 1 person (4%) showed STD. During the early follow-up period (14 +/- 11 days after hospital admission), cardiac events occurred in 11 patients [7 (32%) in Group A and 4(8%) in Group B, p < 0.01], including 6 cardiac death [5 (23%) in Group A and 1 (2%) in Group B, p < 0.01], 3 acute coronary artery bypass surgeries [2 (9%) in Group A and 1 (2%) in Group B, p = NS], and 2 nonfatal myocardial infractions (both in Group A, p = NS). During a mean follow-up period of 3 years (36 +/- 15 months), 18 patients died [10 (45%) in Group A and 8 (15%) in Group B, p = 0.01]. Eleven deaths were sudden [7 (32%) in Group A and 4 (8%) in Group B, p < 0.01]. Eighteen AMI occurred [11 (50%) in Group A and 7 (13%) in Group B, p < 0.005]. Twenty patients underwent revascularization procedures [7 (32%) in Group A and 13 (25%) in Group B, p = NS].(ABSTRACT TRUNCATED AT 250 WORDS)

Diagnosis, Computer-Assisted↗
PubMed1995

Prognostic value of exercise stress testing versus ambulatory electrocardiography after acute myocardial infarction: a 3 year follow-up study.

BACKGROUND: The aim of this study was to evaluate the prognostic significance of myocardial ischemia detected by ambulatory ECG monitoring (AEM) and exercise stress testing (ExT) following acute myocardial infarction. METHODS: The prognostic value of AEM versus ExT was studied prospectively in 74 patients with a recent acute myocardial infarction. Myocardial ischemia was diagnosed by the presence of ST-segment depression occurring during AEM or ExT 4 +/- 2 and 7 +/- 4 days after hospital admission respectively. ST-segment depression during AEM was defined as a horizontal/downsloping depression of > or = 0.1 mV from the reference baseline, measured 80 ms after the J point, elapsing > or = 1 min. ST-segment depression at ExT was determined as > or = 1mm horizontal or downsloping ST-segment depression in at least two consecutive ECG leads. RESULTS: Twenty-two patients (30%) showed ST-segment depression during AEM and 34 (49%) on ExT. During a mean follow-up period of 3 years (36 +/- 15 months), 10 patients (45%) with ST-segment depression on AEM died compared with eight (15%) without; 12 patients (35%) with ST-segment depression on ExT died versus three (8%) without. Death or reinfarction occurred in 13 patients (59%) with ST-segment depression on AEM versus nine (17%) without, and in 13 patients (38%) with ST-segment depression on ExT compared with six (17%) without. Revascularization procedures were similar in patients with or without ST-segment depression during AEM and ExT. Cardiac events defined as death, nonfatal reinfarction or revascularization, occurred in 18 patients (82%) with ST-segment depression on AEM versus 20 (38%) without, and in 23 patients (68%) with ST-segment depression on ExT versus 11 (31%) without. Survival analysis using Kaplan-Meier curves showed that patients showing no ST-segment depression with either technique had longer survival times than did patients showing ST-segment depression on either AEM or ExT, or showing ST-segment depression with both techniques. This was also true when analyzing the cumulative survival rate until the occurrence of any endpoint. With multivariate regression analysis, ST-segment depression on AEM was the variable most strongly predictive of mortality, followed by ST-segment depression on ExT, hypertension, and diabetes. CONCLUSIONS: These findings illustrate the ability AEM and Ext independently to predict long-term cardiac mortality and morbidity rates in patients recovering from acute myocardial infarction. The combined use of these techniques is useful for detecting patients at high risk after acute myocardial infarction.

Electrocardiography, Ambulatory↗
PubMed1990

[Mortality by crushing in domestic pigs: study of the causes and their relationship to the time and the month of the year in the climatic conditions of Cuba].

In the course of 3 years a complex of 25,000 pigs were investigated once per week for the dead among the 398 sucking piglets, and in the case of losses due to crushing to death the type of lesions and the connection with diseases was investigated. Of the piglets investigated, 88 were crushed to death (21.2%), among them 65 (73.8%) diseased--mainly infected by coli bacilli (60 = 68.2%)--and 23 (5.8%) healthy animals. The losses due to crushing to death were highest in January and differed from all other months of the year (p less than 0.05). Another peak of losses in July was only significant (p less than 0.05) as compared with the values of April and November. January and July also exhibited the highest proportion of coli-infected piglets. The most frequent lesions were edema and cyanosis of the skin, of the mucous membrane, and the hypodermic tissue, haemothorax and haemoperitonaeum, liver cracks, lung cracks, kidney cracks, stomach cracks, large intestine cracks, and multiple fractures of the ribs and of the skull. It is concluded that the losses due to crushing to death can be related to the decrease in vitality of the piglets due to diseases, caused in winter by decreased vitality and in summer by pressure caused by coli infection.

Animals↗
PubMed1987

The effects of postoperative factors on serum thyroid hormones and rat liver nuclear 3,5,3'-triiodothyronine receptor concentrations in surgical models of uremia and regenerating liver.

We have determined the individual effects of postoperative fasting, surgical/anesthetic factors, acute uremia (AU), and regenerating liver (RL) on nucleoplasmic (NP; 0.15 M KCl-extractable) and chromatin-bound (CB; 0.4 M KCl-extractable) rat liver T3 receptors. AU and RL rats were studied 24 h after bilateral nephrectomy (blood urea nitrogen, 128 +/- 13 mg/dl) or two thirds hepatectomy, respectively. The effects of postoperative fasting were assessed by comparison of normal rats (N) with control rats (N6) pair-fed to match the caloric intake of the AU and RL rats. Surgical/anesthetic effects were determined by comparison of N6 rats with sham-operated pair-fed rats (S6). The effects of AU or RL were obtained by comparison with S6 controls. Changes in mean body weight attributable to fasting (N6-N), surgical/anesthetic effects (S6-N6), acute uremia (AU-S6), and regenerating liver (RL-S6) were: -17.3 (P less than 0.001), -4.0 (P = NS), -4.5 (P less than 0.05), and -1.0 g/24 h (P = NS), respectively. Changes in mean serum T4 (N, 5.3 +/- 1.3 micrograms/dl) were: -1.0 (P = NS), -0.6 (P = NS), -0.9 (P less than 0.05), and -1.0 micrograms/dl (P less than 0.05), respectively. Changes in mean serum T3 (N, 53 +/- 23 ng/dl) were: -8 (P = NS), -18 (P less than 0.05), -10 (P = NS), and -14 ng/dl (P less than 0.05), respectively. The NP and CB receptor pools of the AU and RL rats were not significantly different from those of age-matched N rats (NP, 25 +/- 5 fmol/mg DNA; CB, 405 +/- 134 fmol/mg DNA). Chronically uremic (CU) rats 2 weeks after five sixths nephrectomy (blood urea nitrogen, 36 +/- 2 mg/dl) did not exhibit significant change in their extractable receptor pools. Complete starvation for 24 h (NO) or 72 h (NOO) generally resulted in marked reductions in receptor concentrations compared to those in age-matched N rats fed ad libitum: NP pool (N, 31 +/- 17 fmol/mg DNA): NO-N, -40% (P = NS); NOO-N, -59% (P less than 0.01); CB pool (N, 303 +/- 105 fmol/mg DNA): NO-N, -19% (P less than 0.05); NOO-N, -41% (P less than 0.001). These studies indicate that severe AU, moderate CU, and LR have relatively little effect on solubilized rat liver nuclear receptor concentrations. In contrast, complete starvation is a potent depressant of both nuclear receptor pools. In the surgical models of AU and LR, postoperative fasting was the primary cause of weight loss.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1985

Telangiectatic hamartoma of the iris and ciliary body.

Two cases of telangiectatic hamartoma of the iris and ciliary body are reported, one of them with its histopathological study. No previous cases have been found, as such, in the current literature. The most important descriptions of primary vascular lesions of the iris and ciliary body are briefly reviewed.

Adult↗
PubMed1984

[Familial mucosal neuromatosis: a minor form of the MEN-2b syndrome].

When the alert ophthalmologist found visible corneal nerves on a clear stroma, he must remind about the multiple endocrine neoplasia syndrome (M.E.N.-2b) and look for the medullary carcinoma of thyroid and the pheochromocytomas. Recognition of these ocular lesions as components of the syndrome is of the utmost importance because prompt identification of individuals affected by multiple endocrine neoplasia type 2 b facilitates early treatment of associated medullary thyroid carcinomas and pheochromocytomas. These endocrine neoplasias must be carefully searched by endocrine means. We present for the first time, in our knowledge, one family with M.E.N.-2b syndrome without endocrine neoplasias at this moment. We think it can be one minor presentation. We call this form "familial multiple mucosal neuromas".

Adolescent↗