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Biomedical subjects

M Q Islam

Publications and source records attributed to M Q Islam.

41 records · Page 3Linked to original sources
PubMed1988

Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat.

Two different factor V cDNA fragments were used as hydridization probes in the chromosomal assignment of the human and rat factor V genes. A 1.6-kb EcoRI fragment was used as a hybridization probe to analyze a panel of human-rodent somatic cell hybrids. Cosegregation of factor V specific DNA restriction fragments with human chromosome 1 was observed. In addition, a panel of rat-mouse somatic cell hybrids was analyzed with another human factor V cDNA probe to localize the gene for rat coagulation factor V. In the rat, the gene for coagulation factor V was found to be located in chromosome 13. This is the first gene in the rat to be localized to chromosome 13.

Animals↗
PubMedDate not supplied

Sexually transmitted diseases in the 1990s. Global epidemiology and challenges for control.

Epidemiologic trends of STD are strikingly different in various parts of the world. In Northern and Western Europe there has been a spectacular decline in the incidence of STD, particularly gonorrhea and syphilis. It is probably due to a combination of an early initiation of sex education at school, behavior change, condom promotion, and the wide availability of STD treatment. The situation in North America is far more complex, with geographic areas and large population groups having low levels of STD and others continuing to experience an epidemic of STD, particularly inner-city minority populations in the United States. In developing countries both the prevalence and incidence of STD are still very high and STDs are a major public health problem making up the second cause of healthy life lost in women of 15 and 45 years of age after maternal morbidity and mortality. "Business as usual" is clearly not acceptable any longer. A better understanding of the determinants of STD epidemiology is essential for a more effective approach to STD control as well as recognizing the limitations of each single intervention, be it medical or behavioral. The major challenges are to mobilize political commitment and funds, and to transfer small scale interventions into large scale public health programs, and to apply the right mix of approaches, including medical, behavioral, societal interventions.

Adolescent↗
PubMedDate not supplied

Development of sexually transmitted diseases treatment guidelines, 1993. New methods, recommendations, and research priorities. STD Treatment Guidelines Project Team and Consultants.

To develop the 1993 Sexually Transmitted Diseases Treatment Guidelines, experts from the Centers for Disease Control and Prevention reviewed the literature on sexually transmitted disease treatment, assembled tables of evidence, and listed key questions on therapeutic outcome: microbiologic cure, alleviation of symptoms, and prevention of sequelae and transmission. At a meeting with external experts, evidence was systematically assessed and guidelines developed. Quality of evidence for microbiologic cure was generally good for gonorrhea and chlamydia, poor for syphilis, and fair for most other diseases. Evidence on preventing sequelae and transmission was limited. The Guidelines include new recommendations for single-dose oral therapy of gonorrhea (cefixime, ciprofloxacin, and ofloxacin), chlamydia (azithromycin), and chancroid (azithromycin); outpatient therapy of pelvic inflammatory disease (ofloxacin and either clindamycin or metronidazole); and patient-applied therapy of genital warts (podofilox). Syphilis therapy did not change substantially. Several global issues that emerged during the development of the World Health Organization Recommendations for the Management of Sexually Transmitted Diseases also are discussed. This evidence-based approach clarified important treatment issues and the rationale for recommendations, and identified research priorities.

Anti-Infective Agents↗