Search PubMed⌕ Search

Biomedical subjects

M Pritchard

Publications and source records attributed to M Pritchard.

78 records · Page 5Linked to original sources
PubMedDate not supplied

From single site to societal belief: the impact of pediatric oncology nursing research.

This review describes the evolution of pediatric oncology nursing research over the past 25 years. It highlights practice-changing contributions from single-site studies and from multisite trials and discusses strategies for interdisciplinary collaboration. Technological advances that will alter the way in which studies are conducted and findings are disseminated will influence the future of nursing research. Studies implemented by pediatric nurse researchers will continue to influence practice and change how we, and others, view the experience of childhood cancer.

Child↗
PubMedDate not supplied

In vitro irreversible binding of ketoprofen glucuronide to plasma proteins.

Many aryl alkanoic acids are cleared as ester glucuronide excreted in urine. While conjugation with glucuronic acid is generally considered as a detoxication process, this conjugate has been shown over the past decade to be a potentially reactive metabolite, undergoing hydrolysis, intramolecular rearrangement, and irreversible binding to proteins. This study describes the in vitro degradation of biosynthetic ketoprofen glucuronide after incubation with human plasma, human serum albumin solutions at various concentrations (290 and 580 microM), and in protein-free buffer, in physiological conditions (pH = 7.4, 37 degrees C). The protein concentrations chosen correspond to that found in synovial fluid and plasma, respectively. Albumin catalyzed the hydrolysis of the glucuronide, but the extent of the reaction was not dependent on the protein concentration. The irreversible binding of ketoprofen was investigated in identical conditions. Maximal ketoprofen-adduct concentrations were achieved after 3 and 10 hr incubation, and were 6.65, 3.2, and 2.6% of initial ketoprofen in plasma and albumin solutions at 580 and 290 microM, respectively. The difference in binding between plasma and albumin (580 microM) could not be totally attributed to the other major plasma proteins, because no irreversible binding was detected with fibrinogen and gamma globulins, and only 0.14% of ketoprofen was bound to alpha and beta globulins after 3 hr incubation. The covalent interaction with albumin was proportional to conjugate concentration over the range studied (from 5 to 30 micrograms/ml or 11.62 to 69.72 microM).

Blood Proteins↗
PubMedDate not supplied

Inpatient immunization program: eliminating a missed opportunity.

In response to the nation's low immunization rates among preschool-aged children, health care providers need to consider alternate sites as potential opportunities to administer vaccinations. One hospital established a Childhood Immunization Group designed to identify and provide immunizations to hospitalized children, 0-2 years of age. Sixty percent of the over 1,600 children evaluated have required immunizations in which 70% of these were immunized prior to discharge. The integration of primary care with "hospital care" can contribute to improving the immunization rate of preschool-aged children.

Child Health Services↗