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Biomedical subjects

M Popa

Publications and source records attributed to M Popa.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Release of growth hormone, prolactin, LH, FSH and IRI in serum through orally administered 1-proline in high dosage.

Orally given 1-proline in high dosage (500 mg/kg b.w.) resulted in growth hormone (GH) release in 9 healthy, sexually immature children investigated (5 boys and 4 girls). A slight, unsignificant decrease of the mean prolactin level was also noted. Serum immunoreactive insulin (IRI), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) concentrations in serum were not influenced. The possible use of proline loading in high dosage for the detection of GH deficiency especially in small children and in infants is suggested.

Child↗
PubMedDate not supplied

Somatotype of children with gonadal dysgenesis and structural anomalies of genitalia.

The somatotype of 92 children with sexual structural anomalies of whom 28 with female Turner's syndrome, 22 with Klinefelter's syndrome, 20 with adreno-genital syndrome, 14 with hypospadias, 2 with Reinfenstein's syndrome and 6 with feminizing testis was established on the basis of biometric and genetically determined morphologic characteristics (dermatoglyphics, pigment complex). A morphogram utilizing 12 anthropometric and 5 dermatoglyphic parameters was constructed; it can be used in phenotypical differentiation of the anatomo-clinical variants of structural anomalies of the genitalia and gonads. The 12 anthropometric parameters were: weight, stature, height of the head + neck segment, the sternum-symphysis distance, length of arms and legs, the biacromial and bitrochanterian diameters, the circumference of the thorax, abdomen, hips and head. The dermatoglyphic parameters were: the digital delta index, TFRC, a-b ridge count, the ATD angle and the A line obliquity. For longitudinal assessment of the phenotype of children with structural anomalies of genitalia and gonads, the authors propose utilization of the percentile diagrams regarding weight, stature, pubes to floor distance, and the biacromial and bitrochanterian diameters.

Adolescent↗
PubMedDate not supplied

Results of 131I therapy in hyperthyroidism at 7-18 years of age.

Twenty-seven patients aged 7-18 years, with hyperthyroidism and diffuse goite received 131I and 125I in doses of 200-350 muCi/gm of gland. The drug was given in a unique dose to 14 patients and fractioned (maximum 4 doses) to the rest. The total maximum dose was 15 mCi. Doubtless recovery was obtained in 25 cases and probable improvement in another 2 (the patients were lost track of). Exophthalmometric values did not increase in any of the patients and in 2 cases of edematous exophthalmos the protrusion and edema disappeared after this treatment. Clear improvement in the nutritional state occurred and puberty followed a normal course. The incidence of both early and late transient hypothyroidism was 1/25, while permanent hypothyroidism occurred in 5/25. In 5 cases administration of 125I in doses of 500 muCi/gm of gland was not effective and necessitated 131I readministration. It was concluded that radioactive iodine (131 isotope) is an effective radiopharmaceutical for radical treatment of hyperthyroidism in children and adolescents. The therapeutical innocuity of 131I was perfect and the dose of 200-350 muCi/gm of gland was the most adequate. A follow-up of the functional status is however advocated in these patients for detection of late hypothyroidism.

Adolescent↗
PubMedDate not supplied

Somatotyping in the obese children and adolescents.

Age-related somatic variability studied by 15 anthropometric parameters was assessed in 278 subjects (138 boys and 140 girls) aged between 5 and 20 years. Of these, 30% had simple obesity, 10.0% obesity associated with hypothyroidism, 10.0% obesity with diabetes, 25% obesity with adrenocortical reaction, 23.5% functional adiposo-genital syndrome and 1.5% Cushing's syndrome. The peculiarities related to the somatic development as a whole, the degree of bone development, and adiposity are interpreted in the main clinical forms of obesity, on the basis of the morphogram.

Adolescent↗
PubMedDate not supplied

Mild stimulation of serum immunoreactive insulin (IRI) release following large doses of intravenously given glycine to children of normal pituitary function.

In healthy, sexually immature children of both sexes serum IRI levels rose more than expected from random inter-individual variation (i.e. more than 3 standard deviations of the basal level) in 10 out of 21 subjects loaded by glycine. The IRI release by glycine though moderate and not constant is, however, unquestionable. The growth hormone (GH) secretory response to glycine did not change according to the occurrence and/or magnitude of IRI release. It was concluded that GH and IRI stimulatory properties of glycine given intravenously in large doses are completely unrelated.

Adolescent↗