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Biomedical subjects

M Pollock

Publications and source records attributed to M Pollock.

At least 55 records · Page 3Linked to original sources
PubMed1980

Clinical and morphological features of gold neuropathy.

Three cases of gold-related neuropathy are reported. Clinical features include an acute, symmetrically progressive polyneuropathy, focal or generalized myokymia and a tendency for initial neurological deterioration followed by improvement, after cessation of chrysotherapy. The degree of clinical recovery related to maximal disability. Morphological findings on sural nerve biopsies revealed both axonal degeneration and segmental remyelination. Similar peripheral nerve histology was seen in a parallel animal study in which the severity of the neuropathy was dose-related.

Adult↗
PubMed1979

Identical twins with papilloedema and cranial nerve palsies.

Central nervous system involvement has not been reported previously as a manifestation of sarcoidosis in monozygotic twins. Twin sisters developed multiple cranial nerve palsies and papilloedema within a two month period. Clinical features and the course of their diseases were remarkably similar.

Adult↗
PubMed1977

The analysis of collagen in glutaraldehyde-fixed, osmicated peripheral nerve.

Glutaraldehyde fixation and osmication of rat sciatic nerve and human sural nerve did not appreciably alter the apparent weight of collagen in nerve fasciculi as determined by hydroxyproline analysis of hydrolysed samples. The collagen content of autopsied peripheral nerve is unaltered at least up to 24 h after death. The mean endoneurial weight of collagen per fascicle in rat sciatic nerve was 123 mug (all results expressed for 1 cm length). In human sural nerve the mean weight was 57 mug and the mean fascicular volume 1.75 mm3. Human endoneurial collagen fibrils gave a unimodal distribution of diameters with a peak at 40 nm.

Animals↗
PubMed1977

Peripheral nerve abnormality in multiple sclerosis.

Biopsy specimens of sural nerve from 10 patients with multiple sclerosis (MS), of whom only 1 was severely disabled, were assessed by morphometric techniques and compared to nerves from age-matched controls. The frequency of abnormal teased fibers was increased in MS nerve, with many internodes showing at least a 50% reduction in myelin thickness. Myelinated nerve fiber densities were not significantly different in MS and control nerves. Regression analysis of axonal area on number of myelin lamellae indicated a generalized reduction of myelin lamellae in this disorder. It is suggested that peripheral myelin may be involved in multiple sclerosis.

Axons↗
PubMed1977

The important role of fitness determination and stress testing in predicting coronary incidence.

The question of whether there is some effect of status of cardiorespiratory fitness and exercise ECG abnormalities on occurrence of CHD other than their effect on the risk factors of serum cholesterol, blood pressure, glucose, and smoking seems to have been answered in the affirmative by this study. The relative prognostic importance of the measures considered here, the role of exercise, and the interrelationships between fitness, exercise, other risk factors, and CHD provide many interesting hypotheses for continued study. A future investigation will involve a large prospective study in which the risk function to be derived would include stress ECG and treadmill performance as predictor variables. The retrospective approach reported in this paper had certain limitations. It did, however, permit demonstration of new results because, essentially for the first time, all of the important risk factors are measured in the study population and can be evaluated simultaneously.

Adult↗
PubMed1976

Combined therapy with tetrabenazine and pimozide in Huntington's chorea: pilot study.

Current medication for Huntingtons chorea is based on compounds which affect the activity of acetylcholine and dopamine in the basal ganglia and is unsatisfactory. This report describes a small clinical trial of dopamine antagonists, tetrabenazine (Nitoman) and pimozide (Orap). Improvement was early and striking but was not maintained over the trial period of 83 weeks.

Adult↗
PubMed1976

Peripheral nerve morphometry in myotonic dystrophy.

Biopsy specimens of muscle and cutaneous branches of the common peroneal nerve from four patients with myotonic dystrophy (MD) were evaluated by morphometric techniques and compared to age-matched control nerves. Myelinated fiber densities were normal in the superficial and deep peroneal nerves of patients with MD. Internode length and frequency of abnormal fibers was not significantly different in MD and control nerves, nor were the number of myelin lamellae, number of neurofilaments per unit area, or number of microtubules per unit area to axis cylinder area. There was no evidence of morphologic abnormality of peripheral nerve in MD.

Adult↗