IgA nephropathy in two HLA-identical brothers and acute, diffuse proliferative glomerulonephritis in the third, HLA-different brother.
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Biomedical subjects
Publications and source records attributed to M Polenaković.
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We report on a group of 27 patients with minimal-change nephrotic syndrome who presented complete recovery from the nephrotic syndrome and the other clinical signs during follow-up. At the start of the examination an elevated serum urea was found in 10 (37%) and of serum creatinine in 4 (15%) patients. Creatinine clearance was decreased in 10 (37%), systolic blood pressure was elevated in 8 (29%) and diastolic in 11 (41%). Interstitial oedema was found in 3, tubular parenchymal degeneration in 4, slight interstitial mononuclear infiltration in 6 and slight interstitial fibrosis in 1 patient. Complete recovery of renal function was seen in all patients.
This is a fourteen-year follow-up study of patients with primary and secondary glomerulonephritis, diagnosed by percutaneous renal biopsy. The survival curves of 271 patients were determined, applying the method described by Cutler 1958. The term "kidney death" was used for the patients who had died or developed end stage renal failure. The five-year survival rates were: 32 for diffuse proliferative glomerulonephritis (chronic), 22 for focal glomerulosclerosis, 30 for membranoproliferative glomerulonephritis, 62 for membranous nephropathy, 90 for focal and mesangioproliferative glomerulonephritis, and 94 for IgA nephropathy. Two diseases of the secondary glomerulonephritis group were analyzed: renal amyloidosis with a survival rate of 8 and lupus nephritis 51.
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