Search PubMed⌕ Search

Biomedical subjects

M Poisson

Publications and source records attributed to M Poisson.

At least 127 records · Page 7Linked to original sources
PubMed1983

[Intermittent claudication disclosing amyloidosis in a chronically hemodialysed patient with light-chain myeloma].

The occurrence of amyloid deposits in skeletal muscle and its vessels has been noted from a long date in amyloidosis. However, their clinical manifestations have been seldom noticed. The authors report the case of a patient with light-chain myeloma in which an arterial intermittent claudication led to the discovery of muscle vascular amyloid deposits. Muscle signs and symptoms due to amyloidosis and their mechanisms are reviewed.

Amyloidosis↗
PubMed1983

[Lasting focal signs in 2 cases of progressive multifocal leukoencephalopathy].

Two cases of progressive multifocal leukoencephalopathy, which occurred without a clinical setting of immune deficiency and developed as a unifocal brain lesion during 14 and 4 months, are reported. The diagnosis was established only by post mortem study in the first case and after five months by a brain biopsy in the second one. The difficulties of an early diagnosis in such cases should be now reduced with CT scan which may show a relatively specific picture, even when there is only one visible lesion.

Female↗
PubMed1982

Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases.

Progestin receptors (PR) were evaluated in 40 intracranial and 2 spinal meningiomas. PR measured with radiolabelled R 5020 were found in 93% of cases (39/42). PR levels were significantly higher (p = 0.05) in females (mean: 5,720 fmol/gmT) than in males (mean: 3,120 fmol/gmT). Biochemical characterization of the R 5020 saturable binding sites showed that they were mainly cytosolic, had a high affinity constant (Kd approximately equal to 1 nM) and were progestin specific. Correlation with sex suggested some biological activity of PR in meningiomas. Oestrogen receptors (OR) were evaluated in 36 intracranial and 2 spinal meningiomas. OR measured with radiolabelled R 2858 were present in 79% of cases (30/38). OR mean levels were equal in females (mean: 285 fmol/gmT) and in males (mean: 330 fmol/gmT). The relevance of PR and possibly OR in the biology of meningiomas and of leptomeninges was suggested by the presence of receptors in a sample of normal leptomeninges.

Adult↗
PubMed1981

[Malignant glial tumors. Difficulties in histopathological diagnosis (author's transl)].

Various questions are asked to the neuropathologist when the diagnosis of malignant glial tumor is suspected: is there a tumor on the sample? is it a glial tumor? What is the degree of malignancy and the prognosis? Answers to be given are easier if the biopsy has been performed before any treatment than in case of suspicion of tumor recurrence. The limits of the neuropathological methods, as well classical as more up to date ones such as electron microscopy, immunohistochemistry, image analysis or tissue culture and those of other research methods such as biochemistry, are emphasized.

Brain Neoplasms↗
PubMed1980

[Ependymoma of the cauda equina presenting as raised intracranial pressure without ventricular dilatation. One case (author's transl)].

Intracranial hypertension is a rare phenomenon in the development of intra-spinal neoplasm. In the present case, it occurred without ventricular dilatation raising the problem of the underlying mechanism. Perturbations in the CSF reabsorption would appear less likely than an increase in brain volume, where cerebral edema may play an important role.

Adult↗
PubMed1980

Hepatitis B antigen-associated periarteritis nodosa in patients undergoing long-term hemodialysis.

Periarteritis nodosa was observed in three of 266 persistent hepatitis B antigen (HBsAg) carriers undergoing long-term hemodialysis; no cases of necrotizing vasculitis occurred among 384 other patients undergoing dialysis having either no or transient antigenemia. Circulating e antigen, but no e antibody, was found in two of these three patients. The serum level of the third component of complement (C3) was normal in two patients and low in the third. Circulating immune complexes were demonstrated in all three patients, using polyethylene-glycol (PEG) precipitation, PEG-C4, and solid phase C1q tests. HBsAg and anti-hepatitis B antibody (HBsAb) were identified in the PEG precipitates using radioimmunoassay and electron microscopy technics. Direct immunofluorescence performed on a muscle biopsy specimen from one patient was positive for HBsAg, but not for immunoglobulin G (IgG), immunoglobulin M (IgM), C3 or C1q. These data support the hypothesis that circulating immune complexes involving HBsAg may be involved in the pathogenesis of periarteritis nodosa.

Antigen-Antibody Complex↗