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Biomedical subjects

M Pluta

Publications and source records attributed to M Pluta.

At least 37 records · Page 2Linked to original sources

Motor nerve conduction velocity for assessment of gestational age in twins.

During the period from October 1, 1979 to March 31, 1981, 40 maturity tests were made on 20 pairs of twins at the Department of Obstetrics at Berlin-Neukölln Hospital. We therefore used the motor nerve conduction velocity (NCV) of the ulnar nerve combined with the Farr system. Only those children whose gestational age was absolutely certain were examined. A strong correlation emerged between the NCV level for twins and singles (r = 0.8 at p less than 0.0001), so that it was possible to establish the maturity age of twins to an accuracy of +/- 1 week. The levels of the NCV measurement within a pair of twins showed a high degree of agreement (r = 0.9 at p less than 0.0001) in which the average fluctuation amounted to 0.5 m/s = 2-3 days. Even when there was a large variation in the weight of the twins (greater than 300 g or greater than 15%), there were only minimal differences (r = 0.9 at p less than 0.0001). On the other hand, the Farr system deviated significantly in a false-positive direction up to the 38th week of gestation. Measuring the motor NCV of the ulnar nerve proved to be a simple and precise method to assess the neonatal gestational age in twins.

Body Weight↗

Improved spatial and temporal resolution in an apparatus for time-lapse phase contrast ciné micrography of cells in vitro.

An apparatus for time-lapse cinemicrography of living animal cells in vitro is described. It has an increased information capacity in comparison with conventional types of equipment in that successful combination of the highest possible spatial resolution with phase contrast microscopy and an improved temporal resolution provided by flash light illumination has been achieved. The interval between exposures of 1/200 s approximately can be reduced to 1/4s using a negative phase-contrast objective of NA 1 . 3. Negative phase-contrast also appeared to be the best technique for imaging of tiny cell surface structures. Thus the new apparatus is suitable for the study of the patterns of cell surface motility in vitro.

Animals↗

[Human placental lactogen and free estriol in maternal blood before and after external version of the fetus from breech to vertex presentation near to term (author's transl)].

In 51 patients with 53 external versions of the child from breech presentation to vertex presentation near to term under tocolysis, the maternal serum-level of human placental lactogen (HPL) and free estriol (E3) was examined immediately before attempting the version and also 30 minutes and 60 minutes after the version, in order to find out whether these two parameters vary according to stress made on the placenta and fetus. In the whole group these were no significant differences in the HPL and estriol levels 30 and 60 minutes after the version compared with the levels before the version. Furthermore comparisons made with attempted versions with heavier stress on the placenta, such as anterior wall placenta, small volume of amniotic fluid, longer duration of the version, and placenta insufficiency did not lead to any significant HPL or estriol decrease in these groups.

Breech Presentation↗

[Measurement of motor nerve conduction for precise maturity determination in low birth weight newborn infants].

Between 1.10.1979 and 31.1.1981, maturity estimation tests were conducted on 379 eutrophic and 78 hypotrophic neonates at the Department of Obstetrics in Berlin Neukölln by means of motor nerve conduction velocity (NCV) combined with the FARR system. In both eutrophic and hypotrophic infants the median of the nerve conduction velocity rises almost in a straight line from 16.5 m/sec in the 34th week of gestation to 25.7 m/sec in the 41st week. The significance calculation of the nerve conduction velocity of both groups showed no variation (p less than 0,01). On the other hand the maturity estimation made with the FARR system deviated strongly in a false positive direction up to the 38th week of gestation. The measurement of the motor nerve conduction velocity of the ulnar nerve has proved to be a simple and very precise estimation of the postpartum gestational age which makes it possible to distinguish with certainty between premature eutrophic infants and hypotrophic infants of low birthweight.

Gestational Age↗

[External version of the foetus from breech presentation in patients in condition following abdominal caesarean section (author's transl)].

Since 1974 we have performed more than 500 external versions of the fetus from breech to vertex presentation under tocolysis near to term. Among these were 20 patients who had previously had a caesarean section; in 15 cases the version was successful and in 5 cases unsuccessful. There were only 4 cases of short-lasting bradycardia or slight longer-lasting tachycardia in the cardiotocograms. Twice complications occurred (once vaginal bleeding and once umbilical cord presentation) which did not lead to serious consequences. After successful versions made on 15 patients, 10 patients could be delivered vaginally and 5 were delivered by caesarean section. Based on our first results we are of the opinion that a previous caesarean section is not an absolute contraindication for performing an external version.

Anesthesia, Inhalation↗

[Measurement of the motor nerve conduction rate: a precise method of assessing newborn maturity? (author transl)].

During the period 1.10.1979 to 31.1.1981 508 maturity determinations were carried out in 483 infants at the Department of Medical Obstetrics of the Neukölln Hospital in Berlin, using the motor nerve conduction rate of the n. ulnaris in combination with the FARR schema. The median value of the NCR increases from 13.0 m/sec in the 33rd pregnancy week (PW) to 30.4 m/sec in the 44th PW almost in linear progression by 1.58 m/sec per week. Over the entire range the NCR showed a highly significant correlation (r = 0.946 at p greater than 0.00001) with the gestatory age of the infant, whereas the FARR schema differs up to the 38th PW markedly in false-positive direction. Measurement of the motor NCR of the n. ulnaris is evidently a simple and very accurate method for post-partum determination of the gestatory age.

Birth Weight↗

[External version of fetus from breech to vertex presentation near term under tocolysis (author's transl)].

Between 10th May 1974 and 31st June 1980, 12960 births were registered at the Maternity Hospital, Neukölln; in 508 patients 536 (3,9%) external versions of the fetus from breech to vertex presentation near term were performed under tocolysis; of these 53% were successful. The incidence of births with breech presentation and/or transverse presentation could be reduced from 5.4% to 3.7% after the introduction of external version. Whilst the localization of the placenta did not influence the success to a great extent, the number of successful versions increased with advancing parity. No fetal death was caused by the version in 508 patients (536 attempted versions). In 11 attempted versions complications occurred in the form of early partial separation of the placenta and/or umbilical cord presentation. Experience and a more circumspect approach led to a definite decrease in the number of complications. As a result of our findings - and bearing in mind the contraindications and observance of safety measures - the external version can be recommended as a simple method of reducing the risk to infant and mother in the treatment of breech presentations.

Breech Presentation↗

Radioimmunoassay of serum SP 1 and HPL in normal and abnormal pregnancies.

Serum concentrations of the pregnancy-specific beta 1-glycoprotein (SP 1) and human placental lactogen (HPL) were measured by radioimmunoassay in 372 blood samples obtained from 40 women in the second half of a normal singleton pregnancy. The mean level of SP 1 steadily increased from 40 micrograms/ml in the 22nd week of pregnancy to 168 micrograms/ml in the 36th week of gestation and thereafter reached a plateau. The half-life of SP 1 during the first week after delivery was about 39 h. The clinical value of SP 1 in comparison to HPL estimations was assessed in a prospective study of a few high risk pregnancies. There were no significant differences between serum SP 1 and HPL levels in pregnancies complicated by preeclampsia with or without intrauterine growth retardation and in twin pregnancies. Serum HPL and SP 1 levels were equally effective in predicting placental insufficiency with fetal growth retardation.

Female↗

[Pregnancy date disk for inserting into prenatal records].

A pregnancy calculating disk - a loose-leaf insert for the antenatal record card--is intended to improve and relieve the prenatal service. A pregnancy calculating disk together with tables containing signs of risks and times for consultations helps towards speedy orientation in daily practice. The data displayed in graphic form gives the pregnant women information on the official guide-lines regarding recommended consultations and ultrasonic examinations during the course of a normal pregnancy.

Female↗