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Biomedical subjects

M Philipp

Publications and source records attributed to M Philipp.

At least 145 records · Page 8Linked to original sources
PubMed1979

Prediction of lofepramine-response in depression based on response to partial sleep deprivation.

The improvement of depression after partial sleep deprivation in the second half of the night (sd) is tested for its predictory power for the therapeutical efficacy of pharmacotherapy with lofepramine. In a group of 15 patients with depression, we found that in contradiction to the findings of Wirz-Justice and collaborators (1976), the velocity of the antidepressive effect of sd has no predictive value. On the other hand, the amount of depression improvement after sd is of predictive value. This is independent of the time of occurrence of the improvement peak after sd. An improvement of more than 35% measured in the Bf-S or in the H.DRS on the first or the second day after sd is highly predictive for a good response to three weeks of 210 mg lofepramine per day (p = .05).

Clinical Trials as Topic↗
PubMed1979

A double-blind trial with amitriptyline and lofepramine in the treatment of endogenous depression.

A double-blind trial was undertaken to compare the antidepressant efficacy and the side effects of Lofepramine with those of Amitriptyline in the treatment of endogenous depression. The study involves 22 acutely ill endogenously depressive patients. 11 patients were treated with Lofepramine and the remaining 11 with Amitriptyline. The results demonstrate that both substances are effective in the treatment of depression. However, the therapeutical efficacy of Lofepramine is significantly greater than that of Amitriptyline. Furthermore, the tolerance of Lofepramine is better than that of Amitriptyline, and the side effects of Amitriptyline, especially in blood pressure dysregulation, are greater than those of Lofepramine.

Adult↗
PubMed1978

Chronobiology and its implications for pharmacotherapy of endogenous depression.

An open pilot study on 30 in-patients with endogenous depression showed a clear-cut circadian fluctuation of the therapeutical effect of single doses of lofepramine administered at three different times of the day (8 a.m., and 12 p.m.). A single-dose drug schedule with 210 mg lofepramine at 12 p.m. also proved superior (p less than .05) to the conventional divided-dose drug schedule with 70 mg lofepramine at three times of the day. The chronobiological background and the therapeutical consequences of these findings are discussed.

Adult↗
PubMed1977

Binding rates, O--S substitution effects, and the pH dependence of chymotrypsin reactions.

The pH dependence for acylation of alpha-chymotrypsin by N-acetyltryptophan p-nitrophenyl-, p-nitrothiophenyl-, ethyl-, and thiolethyl esters has been studied by the stopped-flow technique. Values for the acylation rate constant, k2, and the binding constant, KS, were obtained by using measurements of phenolate release, for the p-nitrophenyl esters, and proflavin displacement, for the ethyl esters. The oxygen esters tested have slightly higher k2 values, and substantially higher KS values relative to the analogous thiol esters. Whereas k2/KS for the thiolethyl ester is higher than that for the analogous oxygen ester, the k2/KS values for oxy- and thio-p-nitrophenyl esters are nearly identical. These data are interpreted to indicate rate-determining formation of a tetrahedral intermediate in acylation of alpha-chymotrypsin by p-nitrophenyl esters, and rate-determining breakdown of such an intermediate in the case of the ethyl esters. It is also concluded that the oxygen to sulfur substitution causes a substantial increase in the proportion of nonproductive binding in these substrates. pH dependent k2 and KS values were used to calculate values for k1 and k-1, the binding and debinding rate constants for the two p-nitrophenyl compounds. This is the first such calculation based on experimentally determined acylation rate constants.

Chymotrypsin↗
PubMed1977

[Therapy of migraine. Clinical experience with Migraeflux, a new migraine drug].

The new migraine preparation Migraeflux has been subjected to clinical trial in a double-blind cross-over study in 32 single tests. Compared with other products, the 2-phase-preparation Migraeflux is distinguished--due to its antihistaminic ingredient--by the capacity of preventing in 2/3 of the cases the formation of a migraine attack if applied soon during the prodromal phase. If the attack is not prevented, the intensity of pain is lessened in 70% of the remaining cases and the duration of attack is markedly reduced. The preparation proved to be tolerated very well.

Acetaminophen↗
PubMed1977

[Masked subdural hematoma in alcoholics].

Nineteen cases of subdural hematomata in alcoholics are discussed to show the special diagnostic problems that the psychiatrist is faced with when dealing with such a disease picture. Although it is relatively easy to show that subdural hematomata in alcoholics are usually of traumatic origin, yet there is the difficulty of the psychiatrist being confronted with the task of giving medical attention to patients where, anamnestically, the trauma is of secondary importance only, and where psychopathological phenomena are a prime consideration. This syndrome, which is characterized by a fluctuation in consciousness and impulsion, psychomotor retardation, and baseless exaltation, may be regarded as suggesting the presence of a subdural hematoma in a person addicted to the use of alcoholic beverages in excess, even if the medical history of the patient is free from any traumata.

Adult↗
PubMed1973

Influence of Leaving-Group Electronic Effect on alpha-Chymotrypsin: Catalytic Constants of Specific Substrates.

Rate constants and binding constants for the alpha-chymotrypsin-catalyzed hydrolysis of N-acetyltyrosine, tryptophan, and phenylalanine anilides are presented. Both k(cat) and K(m) are independent of electronic effects in the substrate over a range of 9.8 orders of magnitude (as measured by pK of the leaving group). Similarly, K(m) is independent of charge and orientation about the alpha-carbon for various substrates and pseudo-substrates. These results are not consistent with the pretransition state protonation hypothesis; instead, they are discussed in terms of a tetrahedral intermediate that is thermodynamically less stable than the Michaelis complex.

Journal Article↗