On the ultrastructure of Nosema cuniculi in the cells of the Yoshida rat ascites sarcoma.
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Animals↗
Biomedical subjects
M Petri
Publications and source records attributed to M Petri.
The Hopkins Lupus Pregnancy Center: 1987-1991 update.
The course of pregnancy in patients with systemic lupus erythematosus is not known. The Hopkins Lupus Pregnancy Center has followed 64 patients (74 pregnancies) prospectively since 1987. Patients are seen monthly and clinical and pregnancy-related data collected, with particular emphasis on the occurrence of lupus flare. Flare rate during pregnancy was 1.63 per person-year, compared to 0.64-0.65 after delivery or in non-pregnant patients. Flare did not influence pregnancy outcome. Low serum C3 or C4 and high anticardiolipin antibody predicted pregnancy loss, and prednisone dose, aspirin use, diastolic second trimester blood pressure, C3 at first visit, and race predicted preterm birth. Maternal flare and preterm birth are important risks in lupus pregnancy. The latter can be predicted from maternal pregnancy data.
Abortion, Spontaneous↗
[Problems in the use of medicines in enterostomized patients].
The practice of intestinal stoma, transitory or permanent, has a series of implications of a physiological, pharmacological, psychological and communitarian character that must be attended to in an integral and individualised way for each patient. Frequently, the ostomised patient is subjected to pharmacological therapy. However, the foreseeable effect of the medicines administered can be affected by factors related to the stoma. Thus, descriptions have been made of extensive resections of ileum that affect the process of the oral absorption of medicines, especially in pharmaceutical forms of enteric covering, delayed release and pills. This would mean access of the unabsorbed portion of the active principle to the collecting device through the faeces and a possible alteration of the duration and intensity of the pharmacological effect. On the other hand, pharmaco surveillance studies have revealed that numerous active principles produce changes in intestinal motility, either on the basis of its fundamental mechanism of action (laxatives, anti-diarrhoea, prokinetics), or as a collateral or secondary effect (antiacids, antidepressants, antihistamines, opioid analgesics). The appearance of constipation and, especially, of diarrhoea can be disturbing and worrying for ostomised patients, and particularly grave in ileostomised patients, due to the dehydration to which it can give rise. Similarly, changes in the colour and odour of faeces, secondary to the administration of medicines (ferrous salts, aluminium hydroxide, bismuth compounds) can needlessly alarm the patients who detect them in the ostomy collecting device (pouch). All these factors can create difficulties for the adhesion of the patient to the proscribed treatment and, as a result, affect its success. However, they can be avoided, corrected or justified with good counselling by the health professionals involved in caring for enterostomized patient.
Drug Therapy↗
Assessment of systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is the archetypal autoimmune disease given its complex clinical and molecular manifestations. Like the other rheumatic diseases, appropriate management is critically dependent upon the proper assessment of disease activity, organ damage, and quality of life. Here, we describe the components of the comprehensive assessment of SLE, including accurate physical and laboratory diagnosis, monitoring of disease activity, recording of accumulated organ morbidity, and integration of these with the patient's own perceptions of health status and quality of life. In doing so, we will review the most appropriate laboratory tests and indices currently used in standard clinical care and in clinical research.
Disease Progression↗