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Biomedical subjects

M Peter

Publications and source records attributed to M Peter.

At least 181 records · Page 10Linked to original sources
PubMed1984

Formation of nitrite in gastric juice of patients with various gastric disorders after ingestion of a standard dose of nitrate--a possible risk factor in gastric carcinogenesis.

Samples of fasting gastric juice (12-h fasting period) from patients with various upper gastrointestinal complaints and from healthy controls were collected by aspiration immediately before and 30, 90, and 240 min after ingestion of 200 mg nitrate in water. Nitrite concentration in the gastric juice of healthy controls remained essentially in a low concentration range throughout the whole sampling period (median values at various time points, 0.1-1.7 mg/L). Patients with gastric and duodenal ulcers and patients who had undergone proximal-gastral vagotomy did not show significant increases in gastric nitrite at any time when compared with healthy controls, using the Wilcoxon rank sum test. Patients with chronic atrophic gastritis and those who had undergone Billroth I or Billroth II gastric resection, however, showed significant increases in gastric nitrite, sometimes with high individual peaks: 80 mg/L in one patient with chronic atrophic gastritis, 50 mg/L in a Billroth I patient and 200 mg/L in a Billroth II patient. The results show that patients with chronic atrophic gastritis and patients who have undergone Billroth I and Billroth II gastrotomy not only have higher basal nitrite values in their gastric juice (12-h fasting) but also react with significantly higher increases in gastric nitrite to an oral dose of 200 mg nitrate, compared with healthy controls, ulcer patients and patients who have undergone proximal-gastral vagotomy. Higher nitrite levels might lead to an enhanced intragastric formation of N-nitroso compounds, and this might be relevant to the increased gastric cancer risk of these groups of patients.

Duodenal Ulcer↗
PubMed1983

[Oral pancreas function test with FDL in the diagnosis of chronic pancreatitis].

The diagnostic accuracy of a tubeless pancreatic function test--Pancreolauryl (PLT)--was evaluated on 97 patients and healthy controls: we found a pathological result of PLT in 31 (88.6%) of 35 patients with proven chronic pancreatitis and a normal PLT in 30 (90%) of 33 controls with no pancreatic disease. In 29 patients with a defined gastrointestinal disease other than chronic pancreatitis the test result was pathological in 51%. This result points towards a limited specificity of the PLT in this latter group, but shows its usefulness as an indicator for maldigestion accompanying the primary disease. In comparison to firmly established diagnostic means for chronic pancreatitis the PLT result was in accordance with the Secretin-Ceruletide function test in 81.3% with ERCP in 80.9% and with computertomography in 76.4%.

Ceruletide↗
PubMed1982

Nitrite and nitrosamines in gastric juice: risk factors for gastric cancer?

Nitrite and nitrosamine concentrations have been measured in 108 patients undergoing gastroscopy as a part of routine gastrointestinal investigations. The nitrite and nitrosamine values of 20 patients with duodenal and 11 patients with benign gastric ulcer were within the range of the values of 26 normal subjects. The nitrite and nitrosamine concentrations in 32 patients with inflammatory changes of the gastric mucosa were slightly higher than normal values and correlated with the progressive degrees of the severity. In 19 patients with atrophic gastritis the concentrations of nitrite and nitrosamines were significantly elevated in comparison with those of all other groups. Our data suggest a relationship between the constant exposure of an already damaged gastric mucosa to N-nitroso compounds and the known high incidence of gastric cancer in atrophic gastritis.

Atrophy↗
PubMed1981

Nitrite and N-nitroso compounds in the operated stomach.

The concentration of nitrite and N-nitroso compounds was examined in the fasting gastric juice of 44 patients with regard to the known cancer risk of the operated stomach. All patients had been operated for ulcer disease in average 2.5 years previously. Twenty-six age-matched individuals with healthy stomachs figures as a control group. The concentration of nitrite and N-nitroso compounds in the gastric juice of the vagotomized patients (PGV) did not differ from that of the controls. On the other hand, a significant increase of the nitrite concentration was found in gastric juice of patients resected according to Billroth I or II procedure. The fraction of N-nitroso compounds, however, was significantly elevated in comparison to the other gastric juice samples only in the Billroth II-resected stomach. The importance of the increase of nitrite and N-nitroso compounds for the cancer risk inherent to the gastric stump is discussed.

Gastrectomy↗
PubMed1980

Are nitrite and N-nitroso compounds in gastric juice risk factors for carcinoma in the operated stomach?

The concentration of nitrite and N-nitroso compounds was examined in the fasting gastric juice of 44 patients operated on for ulcer disease an average of 2.5 years previously and in 26 age-matched patients with healthy stomachs (controls). The concentration of nitrite and N-nitroso compounds in the gastric juice of the vagotomised patients did not differ from that of the controls. On the other hand, significant increases in nitrite concentrations were found in the gastric juice of patients managed by Billroth I or II procedures. The fraction of N-nitroso compounds was significantly increased only in the Billroth II resected stomach. These findings are relevant to the known cancer risk inherent in the gastric stump.

Bacteria↗
PubMed1980

[Intragastral nitrosation - cancer risk in the operated stomach (author's transl)].

The concentration of nitrite and N-nitroso compounds was examined in the fasting gastric juice of 44 patients with regard to the known cancer risk to the operated stomach. All patients had surgery for therapy of an ulcer disease. The operation had taken place an average of 2.5 years previously. Enlisted as a control group were 26 age-matched individuals with healthy stomachs. The concentration of nitrite and N-nitroso compounds in the gastric juice of the vagotomized patiens (PGV) did not differ from that of the controls. On the other hand, a significant increase of the nitrite concentration was found in the gastric juice of those patients resected according to the Billroth I or II procedures. The fraction of N-nitroso compounds, however, was significantly elevated in relation to the other gastric juice samples only in the Billroth II resected stomach. The importance of the increase of nitrite and N-nitroso compounds to the cancer risk inherent in the gastric stump is the subject of discussion.

Gastrectomy↗
PubMed1980

Late survival following use of intraaortic balloon pump in revascularization operations.

The early and late results of intraaortic balloon pump (IABP) support in 197 patients with pure myocardial revascularization were analyzed. Group I, 61 patients, had IABP support initiated preoperatively; Group II, 99 patients, had IABP support in the operating room because of inability to be weaned from bypass; and Group III, 37 patients, had support instituted for persistent low cardiac output state in the postoperative period. The early results showed that 73% were discharged from the hospital and that delayed use of the IABP was associated with a high mortality and high rate of perioperative myocardial infarction. When the results between men and women were compared, no statistical difference was noted. After a mean follow-up of 18 months, there were 9 late deaths. Three were due to noncardiac causes. The two-year cardiac actuarial survival for the hospital survivors was 96% and all three groups had uniformly good symptomatic relief. After hospital discharge, the late results of patients who required use of the IABP in conjunction with pure myocardial revascularization were the same as for patients who did not require IABP support.

Assisted Circulation↗
PubMed1980

Initial clinical experience with a new temporary left ventricular assist device.

A new, simple left ventricular assist system has been developed and its use in experimental animals has been evaluated. The system achieves ventricular drainage by a transaortic valve cannula and utilizes a new centrifugal pump; the blood access is unique in requiring only a simple end-to-side synthetic graft anastomosis to the ascending aorta. Adequate pulsatility is obtained by concomitant use of an intraaortic balloon pump. This case report documents our initial clinical experience with this system in a postoperative patient with profound left ventricular failure unresponsive to all usual treatment. There was temporary recovery of left ventricular function upon decannulation after five and a half days of assist pumping. Despite the eventual death of the patient, the system functioned adequately, suggesting that it has good potential for use in a small, selected group of patients.

Assisted Circulation↗
PubMed1979

Blood conservation during myocardial revascularization.

A prospective study of blood utilization in 50 consecutive patients undergoing elective coronary artery bypass was undertaken. Blood was removed from all patients during induction of anesthesia and reinfused after bypass (mean, 675 ml). Intraoperatively, all discard suction was routed through a regionally heparinized collecting and processing system, and the resulting red cell concentrate was transfused. At the conclusion of bypass, all blood remaining in the pump oxygenator was retained for transfusion. After operation, shed mediastinal blood was collected in a sterile, filtered collection system and transfused. Normovolemic anemia was accepted in hemodynamically stable patients. The mean amount of patients' blood salvaged by the intraoperative system was 259 ml (range, 0 to 724 ml) and by the postoperative system, 194 ml (range, 0 to 564 ml). Ninety-four percent (47/50) of the patients received no bank blood or blood products during their hospital stay. No patients received bank blood intraoperatively or during the first 24 hours following operation. There were no complications attributable to blood salvage techniques.

Adult↗
PubMed1979

Footedness of left- and right-handers.

The performance on a simple tapping task of the hands and feet of left- and right-handers was tested. Right-handers tapped faster with their right hand and right foot. Left-handers tapped faster with their left hand and right foot. Thus, footedness follows handedness in right-handers but not in left-handers. Left-handers showed smaller left/right differences than right-handers in both hand and foot performance. These data are in loose agreement with the modified genetic theory of handedness proposed by Annett (Hand preference and the laterality of cerebral speech, Cortex, 1975).

Adolescent↗
PubMed1975

Thigh emphysema and hip pain secondary to gastrointestinal perforation.

A patient presenting with thigh emphysema and hip pain may suggest intra-abdominal pathology. Three new and 19 previously reported cases of thigh emphysema secondary to bowel disease are reviewed. The thigh and hip manifestations can obscure the primary intra-abdominal process either due to the obvious emphysema or to the obtunded abdominal signs secondary to associated neuropathy. Only one of 22 patients with thigh emphysema secondary to bowel perforation had gas gangrene. Early diagnosis of this clinical association is essential since eight of the 11 deaths occurred within a few days after admission. Right-sided thigh emphysema suggests appendicitis, whereas left-sided emphysema is more likely to be secondary to left colonic diverticulitis or carcinoma.

Appendicitis↗