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Biomedical subjects

M Perduca

Publications and source records attributed to M Perduca.

33 records · Page 2Linked to original sources
PubMed1985

Phosphatidyl-serine inhibition of OC43 and NCDCV coronavirus infectivity.

Human OC43 and bovine neonatal calf diarrhoea coronavirus (NCDCV) are known to be inhibited by non-antibody factors present in sera of different mammalian species, including man and cattle. Such an inhibitor is also present in fetal calf serum generally used for growing and maintaining cell cultures, thus influencing the viral infectivity titer. Previous reports refer to the effectiveness of phospholipase C treatment in eliminating the inhibiting activity. In order to detect the compound possibly involved in coronavirus growth inhibition (among the phospholipids naturally present in mammalian sera), we tested several phospholipids with hemagglutino-inhibition test and plaque reduction assay. Only phosphatidyl-serine seemed to be effective on Coronavirus OC43 and NCDCV, as detected by plaque-reduction assay, but not by hemagglutino-inhibition test.

Animals↗
PubMed1984

Relationship between beta-lactamases production and resistance to beta-lactam antibiotics in clinical isolates of Enterobacteriaceae.

288 clinical isolates of Enterobacteriaceae were assayed for beta-lactamase production in order to assess the role played by beta-lactamases in resistance to beta-lactam antibiotics. The data obtained showed that beta-lactamase production is undoubtedly a fundamental determinant for resistance. In fact, there was a significant correlation between the specific activity of the enzyme and the MIC of the strains considered. However, the role played by permeability barriers and/or other factors should be stressed, especially in determining resistance to cephalosporins. The validity of the nitrocefin test for detection of beta-lactamase production in Enterobacteriaeae from clinical isolates was also investigated.

Anti-Bacterial Agents↗
PubMed1983

[Epidemiologic observations on Chlamydia trachomatis infections].

A group of 82 patients (77 with urethritis) was studied for the presence of Chlamydia trachomatis infection. The agent was isolated by inoculation on McCoy cell cultures, followed by Giemsa and/or Lugol-iodine staining. The results obtained showed that the frequency of Chlamydia trachomatis infection in the group of patients considered was comparable with that previously reported on other groups. Male patients showed a higher infection rate than females. Different percentages of positivity were obtained in patients with gonococcal infection and in those with post-gonococcal urethritis.

Chlamydia Infections↗
PubMed1978

R factors from Enterobacter group.

Twenty-six R factors transmissible to E. coli K12 were derived from 79 strains of Enterobacter species isolated in various clinical specimens (urine, sputum, blood, pus); 71 of 79 strains were Enterobacter cloacae. Fifteen R factors were fi+: 14 belonged to group FII, 1 to group FI. Eleven R factors were fi-: 5 belonged to group M, of the others 6 (all controlling the cloramphenicol-resistance) 1 was recognized of group K, 1 was incompatible with standard plasmids of both groups S and W, and 4 belonged to group S.

Anti-Bacterial Agents↗
PubMedDate not supplied

Fungaemia in hospitalized patients.

At various clinics of IRCCS S. Matteo Hospital, Pavia, Italy, 269 blood cultures recovered from immunocompromised patients over 4 years have been examined mycologically. Of the 269 cultures, 101 were from HIV-infected patients and five were from cardiac transplant recipients. Of the total examined 96 blood cultures were positive (36%). The most frequent genus was Candida: C. albicans (48%), C. tropicalis and C. parapsilosis (8% each), C. glabrata and C. guillermondii (3% each). Cryptococcus neoformans was detected in 21 patients (22%).

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

[Prevalence and transferability of the plasmid lac+ character in "Klebsiella" sp. strains with "lac+-forte" phenotype].

36 strains of Klebsiella sp. showing a strong lactose-positive phenotype were examined for presence of R factors and for ability to promote the transfer of character lac+; 10 of the 13 R+ strains were able to transfer lac+ character and 4 showed the presence of R-lac factors. Transfer of R-lac factors from Klebsiella sp. strains to Salmonella typhi clinical isolates has also been obtained.

Anti-Bacterial Agents↗