Biomedical subjects

M Pelliccioni

Publications and source records attributed to M Pelliccioni.

At least 19 recordsLinked to original sources

PubMed2006

Human exposure to space radiation: role of primary and secondary particles.

Human exposure to space radiation implies two kinds of risk, both stochastic and deterministic. Shielding optimisation therefore represents a crucial goal for long-term missions, especially in deep space. In this context, the use of radiation transport codes coupled with anthropomorphic phantoms allows to simulate typical radiation exposures for astronauts behind different shielding, and to calculate doses to different organs. In this work, the FLUKA Monte Carlo code and two phantoms, a mathematical model and a voxel model, were used, taking the Galactic Cosmic Rays (GCR) spectra from the model of Badhwar and O'Neill. The time integral spectral proton fluence of the August 1972 Solar Particle Event (SPE) was represented by an exponential function. For each aluminium shield thickness, besides total doses the contributions from primary and secondary particles for different organs and tissues were calculated separately. More specifically, organ-averaged absorbed doses, dose equivalents and a form of 'biological dose', defined on the basis of initial (clustered) DNA damage, were calculated. As expected, the SPE doses dramatically decreased with increasing shielding, and doses in internal organs were lower than in skin. The contribution of secondary particles to SPE doses was almost negligible; however it is of note that, at high shielding (10 g cm(-2)), most of the secondaries are neutrons. GCR organ doses remained roughly constant with increasing Al shielding. In contrast to SPE results, for the case of cosmic rays, secondary particles accounted for a significant fraction of the total dose.

Astronauts↗

PubMed2006

Randomized, double-blind, placebo-controlled trial of phenylbutyrate in spinal muscular atrophy.

OBJECTIVE: To assess the efficacy of phenylbutyrate (PB) in patients with spinal muscular atrophy in a randomized, double-blind, placebo-controlled trial involving 10 Italian centers. METHODS: One hundred seven children were assigned to receive PB (500 mg/kg/day) or matching placebo on an intermittent regimen (7 days on/7 days off) for 13 weeks. The Hammersmith functional motor scale (primary outcome measure), myometry, and forced vital capacity were assessed at baseline and at weeks 5 and 13. RESULTS: Between January and September 2004, 107 patients aged 30 to 154 months were enrolled. PB was well tolerated, with only one child withdrawing because of adverse events. Mean improvement in functional score was 0.60 in the PB arm and 0.73 in placebo arm (p = 0.70). Changes in the secondary endpoints were also similar in the two study arms. CONCLUSIONS: Phenylbutyrate was not effective at the regimen, schedule, and duration used in this study.

Child↗

PubMed2006

Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study.

The aim of this study was to validate the Hammersmith functional motor scale for children with spinal muscular atrophy in a large cohort of 90 non-ambulant children with spinal muscular atrophy type 2 or 3. All had a baseline assessment (T0) and were reassessed either at 3 months (T1) (n = 66) or at 6 months (T2) (n = 24). Inter-observer reliability, tested on 13 children among 3 examiners, was > 95%. Of the 66 children examined after 3 months 4 had adverse effects in between assessments and were excluded from the analysis. Forty-two (68%) of the remaining 62 reassessed had no variation in scores between T0 and T1 and 13 (21%) were within +/- 1 point. 9 (37.5%) of the 24 children reassessed after 6 months had no variation in scores between T0 and T2 and another 9 (37.5%) had variations within +/- 1 point. Our study confirms previous observations of the reliability of the scale and helps to establish a baseline for assessing changes of functional ability over 3 and 6 month intervals. This information can be valuable in view of therapeutic trials.

Child↗

PubMed2005

The FLUKA code: new developments and application to 1 GeV/n iron beams.

The modeling of ion transport and interactions in matter is a subject of growing interest, driven by the continuous increase of possible application fields. These include hadron therapy, dosimetry, and space missions, but there are also several issues involving fundamental research, accelerator physics, and cosmic ray physics, where a reliable description of heavy ion induced cascades is important. In the present work, the capabilities of the FLUKA code for ion beams will be briefly recalled and some recent developments presented. Applications of the code to the simulation of therapeutic carbon, nitrogen and oxygen ion beams, and of iron beams, which are of direct interest for space mission related experiments, will be also presented together with interesting consideration relative to the evaluation of dosimetric quantities. Both applications involve ion beams in the AGeV range.

Carbon↗

PubMed2005

A mathematical model of aircraft for evaluating the effects of shielding structure on aircrew exposure.

To investigate the influence of the aircraft structures and contents on the exposure of aircrew to the galactic component of cosmic rays, a mathematical model of an aeroplane has been developed. The irradiation of the mathematical model in the cosmic ray environment has been simulated using the Monte Carlo transport code FLUKA. Effective dose andambient dose-equivalent rates have been determined inside the aircraft at several locations along the fuselage at a typicaI civil aviation altitude. A significant effect of the shielding of aircraft structures has been observed on the ambient dose-equivalent rates, while the impact on the effective dose rates seems to be minor. Care should be taken in positioning the detectors onboard when the measurements are aimed at validating the codes.

Aerospace Medicine↗

PubMed2005

FLUKA simulation of TEPC response to cosmic radiation.

The aircrew exposure to cosmic radiation can be assessed by calculation with codes validated by measurements. However, the relationship between doses in the free atmosphere, as calculated by the codes and from results of measurements performed within the aircraft, is still unclear. The response of a tissue-equivalent proportional counter (TEPC) has already been simulated successfully by the Monte Carlo transport code FLUKA. Absorbed dose rate and ambient dose equivalent rate distributions as functions of lineal energy have been simulated for several reference sources and mixed radiation fields. The agreement between simulation and measurements has been well demonstrated. In order to evaluate the influence of aircraft structures on aircrew exposure assessment, the response of TEPC in the free atmosphere and on-board is now simulated. The calculated results are discussed and compared with other calculations and measurements.

Aerospace Medicine↗

PubMed2004

Monte Carlo calculation of the angular distribution of cosmic rays at flight altitudes.

The angular distribution of the secondary radiation produced by the galactic component of cosmic rays has been determined by simulating the penetration of the primary spectra in the Earth's atmosphere. The simulations have been carried out with the latest version of the FLUKA code. Particles have been scored at various altitudes according to their angle of incidence for some significant values of vertical cut-off rigidity and solar modulation parameter. The calculated results at typical cruise altitudes for a civil aircraft are presented. The data at 10.7 km have been fitted with simple mathematical equations. It has been demonstrated that the major contribution to the doses at aviation altitudes arises from downward-directed particles. The isotropic irradiation usually assumed for the evaluation of aircrew exposure could be a very poor approximation.

Aircraft↗

PubMed2004

The FLUKA code for space applications: recent developments.

The FLUKA Monte Carlo transport code is widely used for fundamental research, radioprotection and dosimetry, hybrid nuclear energy system and cosmic ray calculations. The validity of its physical models has been benchmarked against a variety of experimental data over a wide range of energies, ranging from accelerator data to cosmic ray showers in the earth atmosphere. The code is presently undergoing several developments in order to better fit the needs of space applications. The generation of particle spectra according to up-to-date cosmic ray data as well as the effect of the solar and geomagnetic modulation have been implemented and already successfully applied to a variety of problems. The implementation of suitable models for heavy ion nuclear interactions has reached an operational stage. At medium/high energy FLUKA is using the DPMJET model. The major task of incorporating heavy ion interactions from a few GeV/n down to the threshold for inelastic collisions is also progressing and promising results have been obtained using a modified version of the RQMD-2.4 code. This interim solution is now fully operational, while waiting for the development of new models based on the FLUKA hadron-nucleus interaction code, a newly developed QMD code, and the implementation of the Boltzmann master equation theory for low energy ion interactions.

Computer Simulation↗

PubMed2004

Role of shielding in modulating the effects of solar particle events: Monte Carlo calculation of absorbed dose and DNA complex lesions in different organs.

Distributions of absorbed dose and DNA clustered damage yields in various organs and tissues following the October 1989 solar particle event (SPE) were calculated by coupling the FLUKA Monte Carlo transport code with two anthropomorphic phantoms (a mathematical model and a voxel model), with the main aim of quantifying the role of the shielding features in modulating organ doses. The phantoms, which were assumed to be in deep space, were inserted into a shielding box of variable thickness and material and were irradiated with the proton spectra of the October 1989 event. Average numbers of DNA lesions per cell in different organs were calculated by adopting a technique already tested in previous works, consisting of integrating into "condensed-history" Monte Carlo transport codes--such as FLUKA--yields of radiobiological damage, either calculated with "event-by-event" track structure simulations, or taken from experimental works available in the literature. More specifically, the yields of "Complex Lesions" (or "CL", defined and calculated as a clustered DNA damage in a previous work) per unit dose and DNA mass (CL Gy-1 Da-1) due to the various beam components, including those derived from nuclear interactions with the shielding and the human body, were integrated in FLUKA. This provided spatial distributions of CL/cell yields in different organs, as well as distributions of absorbed doses. The contributions of primary protons and secondary hadrons were calculated separately, and the simulations were repeated for values of Al shielding thickness ranging between 1 and 20 g/cm2. Slight differences were found between the two phantom types. Skin and eye lenses were found to receive larger doses with respect to internal organs; however, shielding was more effective for skin and lenses. Secondary particles arising from nuclear interactions were found to have a minor role, although their relative contribution was found to be larger for the Complex Lesions than for the absorbed dose, due to their higher LET and thus higher biological effectiveness.

Astronauts↗

PubMed2004

Evaluation of the influence of aircraft shielding on the aircrew exposure through an aircraft mathematical model.

In order to investigate the influence of aircraft shielding on the galactic component of cosmic rays, an aircraft mathematical model has been developed by the combinatorial geometry package of the Monte-Carlo transport code FLUKA. The isotropic irradiation of the aircraft in the cosmic ray environment has been simulated. Effective dose and ambient dose equivalent rates have been determined inside the aircraft at several locations along the fuselage, at a typical civil aviation altitude (10 580 m), for vertical cut-off rigidity of 0.4 GV (poles) and 17.6 GV (equator) and deceleration potential of 465 MV. The values of both quantities were generally lower than those in the free atmosphere. They depend, in an intricate manner, on the location within the aircraft, quantity of fuel, number of passengers, etc. The position onboard of crew members should be taken into account when assessing individual doses. Likewise due consideration must be taken when positioning detectors which are used to measure H*(10). Care would be needed to avoid ambiguity when comparing the results of calculation with the experimental data.

Aircraft↗

PubMed2004

Dosimetric considerations on TEPC fluka-simulation and measurements.

The response of a tissue equivalent proportional counter (TEPC) has been simulated with the Monte Carlo transport code FLUKA. The absorbed dose distribution of lineal energy y has been determined for several monoenergetic photon and neutron sources. The agreement between the calculated results and the measurements carried out with different well-known sources is well demonstrated. Work is in progress in order to evaluate the response of the instrument in the cosmic ray environment.

Algorithms↗

PubMed2004

The impact of ICRP publication 92 on the conversion coefficients in use for cosmic ray dosimetry.

ICRP Publication 92 presents a proposal to achieve coherence between radiation weighting factors and quality factors. In particular, the radiation weighting factors for incident protons and neutrons have been revised and new values have been proposed. On the basis of the proposed values, sets of conversion coefficients fluence-to-effective dose for protons and neutrons have been derived for the irradiation geometries of interest for cosmic ray dosimetry.

Body Burden↗

PubMed2003

Estimating mixed field effects: an application supporting the lack of a non-linear component for chromosome aberration induction by neutrons.

The action of neutron fields on biological structures was investigated on the basis of chromosome aberration induction in human cells. Available experimental data on aberration induction by neutrons and their interaction products were reviewed. Present criteria adopted in neutron radiation protection were discussed. The linear coefficient alpha and the quadratic coefficient beta describing dose-response curves for dicentric chromosomes induced by neutrons of different energies were calculated via integration of experimental data on dicentric induction by photons and charged particles into the Monte Carlo transport code FLUKA. The predicted values of the linear coefficients for neutron beams of different energies showed good agreement with the corresponding experimental values, whereas the data themselves indicated that the neutron quadratic coefficient cannot be obtained by 'averaging' the beta values of recoil ions and other nuclear reaction products. This supports the hypothesis that neutron induced aberrations increase substantially linearly with dose, a question that has been object of debate for a long time and is still open.

Chromosome Aberrations↗

PubMed2003

On the conversion coefficients for cosmic ray dosimetry.

Calculations of fluence-to-effective dose conversion coefficients have typically been limited to the standard irradiation geometries of the human body: anterior-to-posterior (AP), posterior-to-anterior (PA), lateral from the right side to the left side (RLAT), lateral from the left side to the right side (LLAT), rotational around the vertical axis (ROT), and isotropic incidence from all directions (ISO). In order to estimate the doses to air crew members exposed to cosmic radiation, the geometrical conditions of irradiation are usually assumed to be isotropic. However, the assumption of isotropic irradiation is in many cases invalid for the high energy component of the radiation field, which is often peaked in the forward direction. Therefore, it was considered useful to extend the calculations of conversion coefficients to other geometries. New sets of conversion coefficients fluence-to-effective dose are presented for the semi-isotropic irradiation of the human body and for the irradiation from the top. Their application to cosmic ray dosimetry is discussed.

Aircraft↗

PubMed2001

Calculation of the radiation environment caused by galactic cosmic rays for determining air crew exposure.

The spectra of secondary particles resulting from interactions of primary galactic cosmic rays with the nuclei in the atmosphere have been calculated using the Monte Carlo transport code FLUKA. The simulations have been carried out at solar minimum and solar maximum activity, for several values of the vertical geomagnetic cut-off. The effective dose rate and the ambient dose equivalent rate as a function of geomagnetic cut-off and altitude have been obtained using appropriate sets of conversion coefficients. The calculated results are discussed and compared with experimental data and other calculations. A simple method is proposed to calculate the radiation exposure at aircraft altitudes.

Aircraft↗

PubMed2001

The Italian national survey of aircrew exposure: I. Characterisation of advanced instrumentation.

The survey of aircrew exposure required the characterisation and/or the development of a diverse array of both passive and active instruments, which were not available at any one laboratory. To ensure the availability of the most advanced dosimetric systems and the relevant calibration facilities needed for the survey, an international collaboration was formed, which was facilitated by multinational research contracts promoted by the Commission of the European Communities. Close cooperation among scientists with long-term experience in different disciplines, such as cosmic ray measurement in space and radiation protection dosimetry, made it possible to exploit successfully damage track detectors for the accurate evaluation of very low fluences of particles with high energy and high charges. For a long time, the major concern for the assessment of aircrew exposure has been the accurate evaluation of the cosmic ray neutron dose. In this paper, four different dosimetric systems are considered, the response of which is sensitive to both low and high energy neutrons. All these dosimetric systems have provided consistent results when exposed together to the high energy beam facility at CERN, which is considered to approximate the cosmic ray field.

Aviation↗

PubMed2001

The Italian national survey of aircrew exposure: II. On-board measurements and results.

The Italian survey of aircrew exposure has been carried out with different advanced dosimetric systems, as described in part I of this paper. The key strategy of the survey was to obtain on-board comparison of measurements for both passive and real-time detectors flown together with passengers. The survey has been carried out in the period of solar minimum (1995-1997), in which the exposure to galactic cosmic rays reaches its maximum value. Even though carrying out the survey in the period of solar minimum was entirely coincidental, this circumstance has been used to good advantage to obtain a comprehensive set of data of the galactic cosmic radiation with little or no disturbance by the solar activity modulation. This comprehensive set of data covers flight routes between -20 degrees and 75 degrees geographic latitude at different civil aviation altitudes. The survey obtained with different advanced dosimetric systems has been supplemented by a large variety of data gathered with passive stacks on different short-range and long-range flights at supersonic and subsonic altitudes. Some of the most important conclusions which can be drawn from the survey are: (i) aircrew of civil aviation receive annual doses within the range of 1 mSv to 6 mSv; (ii) data from different periods of solar minimum agree well, since the discrepancies encountered seem mainly due to the different dosimetric systems used; (iii) repeated measurements on the same route are highly consistent.

Aircraft↗

PubMed2001

Some useful data for narrow beam dosimetry.

Organ doses and effective dose have been estimated in the case of an anthropomorphic mathematical model exposed to monoenergetic narrow beams of various types of incident radiation (photons, electrons, protons) and energies. The target organs considered were right eye, thyroid and breast. Calculations have been carried out using the latest version of the Monte Carlo transport code FLUKA. The investigated energy range was extended from 5 MeV to 10 GeV. In the case of photons, incident energies in the region between 30 keV and 1 MeV were also considered. Preliminary results are presented.

Breast↗