[Effect exerted by a histone fraction (P II) on the formation of antibodies].
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Biomedical subjects
Publications and source records attributed to M Pelletier.
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A total of 1,573,769 blood donations from volunteer blood donors from Connecticut were tested for Hepatitis B Surface Antigen (HBsAg) from 1973 to 1983. The prevalence of HBsAg decreased over this 10 year period among first time as well as repeat donors. This decrease was much more pronounced in the first three years of the study (1973 to 1975) in repeat donors. Thereafter, prevalence was stable. In first-time donors, the largest decrease also occurred in the first three years. In contrast to repeat donors, however, marked fluctuations in the prevalence were noted in first time donors. As has been the case in previous studies, HBsAg prevalence in first-time donors was significantly higher than that observed in repeat donors. Our study encompasses the longest period of observation in comparison to previous reports on HBsAg prevalence among blood donors. While it has been previously established that a decrease in prevalence over time does occur among repeat donors, stabilization of prevalence after an initial reduction found in our study has not been previously documented. This may indicate an irreducible minimum prevalence rate in the repeat donor population. In addition, our study for the first time convincingly demonstrates a reduction in prevalence in first-time donors which may reflect better communications at the donor recruitment and nursing level.
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1. The authors have searched for the existence of mitogenic factor for macrophages in the serums of rats having undergone diverse immune and non-immune inflammatory reactions. 2. The evolution of the mitogenic activity of the inflammatory serums have been studied over a 48 hour period. This study underlined that the appearance of the mitogenic factor is very rapid since it can be found as early as 30 minutes after the injection of the irritant. 3. In most cases the evolution of the mitogenic activity of serums reveals a biphasic aspect: a strong activity is observed 1 to 2 hours after the injection of the irritant followed by a decrease of this activity which becomes weak or even null towards the sixth hour. It then increases to attain, after about 24 hours, values almost equal to those seen for the first peak.
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