Search PubMed⌕ Search

Biomedical subjects

M Pellerin

Publications and source records attributed to M Pellerin.

76 records · Page 5Linked to original sources
PubMedDate not supplied

Progressive latissimus dorsi muscle denervation for free-flap dynamic cardiomyoplasty.

BACKGROUND: The creation of free muscle grafts for surgical myoplasty is limited by the dependence of muscle on its original nerve supply. The aim of this study was to develop a model of gradual denervation of a large skeletal muscle (latissimus dorsi) and evaluate the possibility that atrophic degeneration and loss of function would be reduced using progressive nerve compression instead of surgical division of the nerve. The effects of chronic stimulation prior to, and after, denervation were also evaluated. METHODS: Electrodes connected to a myostimulator were implanted on 24 latissimus dorsi muscles of 12 goats. Denervation of these muscles was achieved either by sectioning of the nerve by progressive compression using ameroid rings placed around the nerve. Electrostimulation of the muscle started either 5 weeks before (prestimulation), or immediately after the denervation. RESULTS: The model of gradual nerve compression was successfully created and did have less atrophy and loss of function at mid-term when compared with nerve division. Chronic electrostimulation of the muscle after nerve division had a beneficial effect on function and on the atrophic process. Chronic electrostimulation in our model of gradual nerve compression did not mirror these beneficial results. Detrimental results were observed in groups in which chronic electrostimulation was applied prior to nerve division or constriction.

Animals↗
PubMedDate not supplied

[Clonidine and treatment of arterial hypertension in the pregnant female].

From the results of a non-controlled trial about the successful use of clonidine in 14 hypertensive pregnant women on and on the basis of a bibliographical analysis, the investigators studied the efficacy and safety of this central acting antihypertensive drug. This risk-improvement study reveals that clonidine can be safely and advantageously prescribed for the treatment of hypertension during pregnancy.

Adult↗