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Biomedical subjects

M Peet

Publications and source records attributed to M Peet.

At least 37 records · Page 2Linked to original sources
PubMed1994

Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants.

The rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (SSRIs) fluoxetine, fluvoxamine, paroxetine, and sertraline, relative to comparative groups treated with tricyclic antidepressants (TCAs) or placebo. In predominantly unipolar depressives, the rate of manic switch is less than 1% and differences between drugs and placebo are statistically but not clinically significant. In bipolar depressives, manic switch occurs substantially more often with TCAs (11.2%) than with SSRIs (3.7%) or placebo (4.2%).

Antidepressive Agents, Tricyclic↗
PubMed1993

Tardive dyskinesia, lipid peroxidation, and sustained amelioration with vitamin E treatment.

Plasma levels of thiobarbituric acid reactive substances (TBARS) were measured as an indicator of lipid peroxidation, in 14 patients suffering from tardive dyskinesia (TD). There was a highly significant positive correlation between plasma TBARS (both basal and iron stimulated) and severity of TD. Patients were then treated for 1 month with the free radical scavenger vitamin E (1200 i.u. daily). Following vitamin E treatment, there was a clinically and statistically significant amelioration of TD, and this improvement was maintained at follow-up 7-13 months later. There was no consistent or significant change in plasma TBARS levels related to treatment with vitamin E.

Adult↗
PubMed1993

Lithium. Current status in psychiatric disorders.

Lithium is the recommended treatment for the prophylaxis of bipolar affective disorder. The drug is also effective in the prophylactic treatment of recurrent unipolar depression, although many psychiatrists prefer to use antidepressant drugs for this indication. The efficacy of lithium is well established in the short term treatment of mania, although neuroleptic drugs are required at the start of treatment for more severely disturbed patients. Lithium augmentation of antidepressant drugs is increasingly popular for the treatment of resistant depression. It is now common practice to maintain serum lithium concentrations in the range 0.5 to 0.8 mmol/L, which is generally as effective as higher concentrations while reducing the incidence of adverse effects and intoxication. Some individuals may nevertheless require higher serum concentrations. Most adverse effects such as tremor and gastrointestinal upset are usually minor and often transient. There is no good evidence of nephrotoxicity with long term treatment, but persistent polyuria can occur. Hypothyroidism, with or without goitre, can occur uncommonly during long term lithium therapy. Prescribers should be alert to, and patients should be educated about, the predisposing factors and early symptoms relating to lithium intoxication. Specialist mood disorder clinics can facilitate safer and more effective lithium treatment.

Affective Disorders, Psychotic↗
PubMed1991

Lithium maintenance: 1. A standard education programme for patients.

A videotape lecture and written hand-out containing factual information about lithium were given to 30 attenders at a lithium clinic. A further 30 patients acted as a control group and were not given the programme until later in the study. The educational programme resulted in substantial and significant increases in patient knowledge about lithium, such that knowledge increased from a baseline comparable with that of social workers to a level similar to that of community psychiatric nurses. Patients' attitudes to lithium also became more favourable after education.

Attitude to Health↗
PubMed1990

Use of carbamazepine in psychosis after neuroleptic malignant syndrome.

A case is described of NMS during treatment with sulpiride. The subsequent psychosis resolved during treatment with carbamazepine. It is proposed that this patient may have suffered from a supersensitivity psychosis, and that resolution of her post-NMS psychosis could have been spontaneous.

Carbamazepine↗
PubMed1989

ECT in old age.

Explore the source record for details and available documents.

Age Factors↗
PubMed1988

Vanadium and other trace elements in patients taking lithium.

The serum concentrations of 24 trace elements were measured by neutron activation analysis in 32 patients on long-term lithium treatment and 32 age- and sex-matched healthy controls. Whole blood and hair samples were also taken from a number of these subjects. Compared to controls, patients on lithium were found to have a lower serum vanadium, a lower serum cobalt, and an elevated serum aluminium level. These findings are discussed.

Adult↗
PubMed1988

The treatment of anxiety with beta-blocking drugs.

Evidence supporting the efficacy of beta blockers in anxiety is reviewed. Propranolol and oxprenolol are the most clearly established in efficacy. A placebo-controlled trial is described, in which propranolol and atenolol were both effective in the symptomatic treatment of generalized anxiety in patients who had been referred by their family doctors for specialist treatment. If initial psychological treatment for chronic anxiety is ineffective, and a drug is considered necessary, then a beta blocker or an antidepressant should be considered as first choice in preference to a benzodiazepine.

Adrenergic beta-Antagonists↗
PubMed1986

Propranolol and atenolol in the treatment of anxiety.

Patients with generalized anxiety who have not responded to psychological treatment from their family doctor may require symptomatic drug treatment whilst awaiting specialist therapy. This study indicates that propranolol is effective and relatively safe for this purpose. Atenolol is also effective but has unacceptable cardiovascular effects in anxious patients.

Adult↗