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Biomedical subjects

M Peacock

Publications and source records attributed to M Peacock.

At least 217 records · Page 12Linked to original sources
PubMed1970

Renal effects of calcitonin.

Porcine calcitonin in a slow-release gelatin vehicle was given by intramuscular injection to 10 patients-four with primary hyperparathyroidism, four with Paget's disease, and two with carcinoma of the breast and hypercalcaemia. All cases showed a fall in serum calcium with an immediate rise in urine calcium. All except three patients with primary hyperparathyroidism showed a fall in serum phosphorus, but an immediate rise in urine phosphorus occurred in all cases. Urine hydroxyproline output fell in three patients with severe Paget's disease. Urine sodium rose in all cases, but the effects on potassium, magnesium, water, and pH were not appreciably different from results obtained in four control subjects who were given the gelatin vehicle alone.The data suggest that calcitonin caused a decrease in the tubular resorption of calcium and phosphorus. The hypocalcaemic effect appeared to be due to a decrease in bone resorption in the patients with Paget's disease but in the remaining cases could be accounted for in part or entirely by the rise in urine calcium.

Aged↗
PubMed1968

Passive cutaneous anaphylaxis with antigens from Coxiella burneti.

Passive cutaneous anaphylaxis (PCA) was produced in guinea pigs sensitized with guinea pig Coxiella burneti phase I-II antiserum and challenged with dimethylsulfoxide- or trichloroacetic acid-soluble extracts from phase I cells. The PCA reaction could not be induced by whole or mechanically disrupted phase I or phase II C. burneti cells or by extracted cells or extracts of phase II cells. The antibody responsible for PCA was in the 7Sgamma(1) (fast gamma) globulin. Sensitization of the skin by 7Sgamma(1) antibody could be blocked nonspecifically by 7Sgamma(1) globulin from normal serum or from phase II antiserum. The 7Sgamma(2) (slow gamma) globulin antibody inhibited the reaction specifically. Some antiserum pools containing high agglutinin and complement-fixing titers to phase I C. burneti cells failed to initiate the PCA reaction, perhaps due to an imbalanced ratio of gamma(1) to gamma(2) specific globulins or to an imbalance in the ratio of specific to nonspecific gamma(1) globulins. Agglutinins to phase I cells were found in both gamma(1) and gamma(2) antibody globulins. Complement-fixing antibodies were found in the gamma(2) globulin fraction.

Agglutination Tests↗
PubMed1968

Tubular reabsorption of calcium in normal and hypercalciuric subjects.

Tubular reabsorption and excretion of calcium were studied at different levels of filtered calcium by means of calcium infusion in normal and hypercalciuric subjects and in patients with idiopathic nephrolithiasis. Calcium reabsorption and excretion rose linearly with filtered load and in no case was a maximum tubular reabsorptive capacity for calcium reached. No decrease in tubular reabsorption of calcium was found in hypercalciuric as compared with normocalciuric subjects, and no difference in tubular reabsorption was found between patients with idiopathic nephrolithiasis and normal subjects. Calcium excretion and reabsorption calculated from the endogenous creatinine clearance during calcium infusion were virtually identical with the corresponding values calculated from the inulin clearance.

Adult↗