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Biomedical subjects

M Payet

Publications and source records attributed to M Payet.

79 records · Page 5Linked to original sources
PubMedDate not supplied

[In vitro study of the sensitivity of Plasmodium falciparum to chloroquine].

In vitro testing of P. falciparum chemosensitivity was assessed from 2 severe malaria cases in which the parasite was thought to be resistant to chloroquine. The 3 following methods were compared in both cases. 1.--Maturation test, carried out before and from the outset of treatment, is a rapid and simple method. Primary efficiency of therapeutic procedures can be estimate and the eventually adjust. 2.--Rieckmann test, on patient blood, measure chemosensitivity of host strain modulated by hosts factors. Initially proposed for epidemiological trials, this method is of interest for the choice of treatment at the end of acute phase in individuals cases. 3.--Strain chemosensitivity measurement, require one or more weeks of Plasmodium cultivation. This value will be very helpful to estimate the sensitivity level of P. falciparum to chloroquine in the outcoming strain area.

Chloroquine↗
PubMedDate not supplied

[Comparative sensitivity of I. F. A. T. using adult Schistosoma antigen and E. L. I. S. A. with ovular antigen in the immunodiagnosis of schistosomiasis (author's transl)].

The sensitivity of I. F. A. T. was compared with E. L. I. S. A. using the first method with cross-sections of adult Schistosoma mansoni (A. S. M.), and the second with ovular S. mansoni soluble extract (O. S. M.), the test sera from 86 schistosomiasis patients (32 with S. mansoni and 54 with S.haematobium) and 100 control sera. Despite the better response of S. mansoni sera in both methods, the significant level of antibody detection (maximum sensitivity for minimum non specificity) was higher for E. L. I. S. A., O. S. M. than for I. F. A. T., A. S. M., especially for urinary schistosomiasis.

Antigens↗