[Keeping records of the neuropsychological development of children in the 1st stages of childhood].
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Biomedical subjects
Publications and source records attributed to M Pavelescu.
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This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans.
Data about synthesis of some oximes and their O-acetyl derivates are shown here. This item also emphasize the results of testing the antimicrobial, antifungal, antilevural and anti-inflammatory action of the synthesized oximes.