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Biomedical subjects

M Paul

Publications and source records attributed to M Paul.

At least 397 records · Page 22Linked to original sources
PubMed1977

Pancreatic glucagon-like immunoreactivity in a pancreatectomized patient.

True or 'pancreatic' glucagon-like immunoreactivity (GLI) was found in the plasma of a pancreatectomized patient. In contrast with the regulation of pancreatic GLI in normal controls, there was paradoxical release after oral glucose, no response to arginine or insulin-hypoglycaemia and somatostatin did not suppress its release, but tolbutamide did. Similar to controls, this pancreatic GLI appeared to be under adrenergic beta-receptor control. There was no apparent effect on blood glucose regulation despite marked changes in pancreatic GLI levels during the various manipulations. On polyacrylamide gel electrophoresis, pancreatic GLI from our patient's plasma eluted as two equivalent peaks: one with the glucagon marker and the other in a more cathodal position. We therefore suggest that, although the extra-pancreatic 'pancreatic' GLI in our patient's plasma has immunologic similarities with pancreatic glucagon, the responses to stimulation and suppression are quite different from those in controls and the biologic activity does not appear to be that of pancreatic glucagon.

Antigens↗
PubMed1976

Evidence for a polyspermy block at the level of sperm-egg plasma membrane fusion in Urechis caupo.

The results of sperm binding experiments reveal no change in the sperm binding properties of the egg surface coat at fertilization of Urechis caupo eggs. When fertilized eggs are reinseminated, sperm continue to attach to the egg surface coat. The acrosomal tubules of supernumerary sperm are observed in the perivitelline space closely apposed to the egg membrane. Thus, the polyspermy block in Urechis eggs involves neither alteration of sperm binding sites nor inhibition of the acrosome reaction. Our results suggest that the block is at the level of sperm-egg membrane fusion.

Acrosome↗
PubMed1976

Fertilization acid of sea urchin eggs is not a consequence of cortical granule exocytosis.

Sea urchin eggs treated with 10 mM NHC1 release a "fertilization acid" although cortical granule exocytosis does not take place. If the eggs are inseminated following ammonia activation, the cortical reaction occurs and a fertilization membrane elevates in the absence of detectable acid release. Examination by electron microscopy of eggs fixed between ammonia activation and insemination confirms the presence of intact granules. Thus, the fertilization acid is not caused by the release of the cortical granules. Ammonia treatment of fertilized eggs stimulates further release of acid. The release of acid can occur repeatedly in ammonia activated eggs if they are washed into normal seawater between successive ammonia treatments. Our results suggest that the release of fertilization acid is related to some metabolic process which can be turned "on or off".

Ammonia↗
PubMed1976

Perforated peptic ulcer in pregnancy with survival of mother and child: case report and review of the literature.

Peptic ulcer in pregnancy and its complications, though rare, can be life-threatening to mother and fetus. Perforated peptic ulcer in pregnancy is extremely rare; when this occurs survival of both mother and child is unusual. Only five cases of maternal survival following perforation of a peptic ulcer have previously been recorded and, of these, only three were associated with survival of both mother and infant. The authors report an additional case of perforated ulcer in pregnancy with survival of mother and infant, and review the relevant literature. Early surgical diagnosis and treatment followed by vaginal delivery of the fetus offers the best hope for survival of mother and child.

Adult↗
PubMed1975

Effect of bromocriptine and chlorotrianisene on inhibition of lactation and serum prolactin. A comparative double-blind study.

A double-blind study to compare the effect of 2-Br-alpha-ergocryptine (bromocriptine, CB 154, Sandoz) an ergot alkaloid with chlorotrianisene (Tace, Mer-National) on the inhibition of postpartum lactation was carried out in 38 women. At the dosages selected bromocriptine was more effective than chlorotrianisene in inhibiting lactation. Furthermore, bromocriptine significantly reduced serum prolactin levels to low normal values by the seventh day of treatment, whereas chlorotrianisene did not alter the normal progressive reduction in prolactin post-partum. Neither drug had significant toxic effects.

Bromocriptine↗
PubMed1975

Prolactin responses to thyrotropin-releasing hromone in protein-calorie malnutrition.

Basal plasma prolactin (hPRL) concentration is low, but the response to thyrotropin-releasing hormone (TRH) is within the normal range, in children with protein-carlorie malnutrition (PCM) before treatment. Treatment results in increased basal hPRL concentration and an increased response to TRH. The above findings contrast with normal or high basal TSH and the normal or exaggerated response to TRH provocation in untreated PCM. The reason for this divergence is obscure.

Child, Preschool↗
PubMed1975

Immunoreactive glucagon responses to intravenous tolbutamide in chronic pancreatitis.

The effects of tolbutamide infusion (1 gm. over forty minutes) on plasma pancreatic glucagon-like immunoreactivity (PGLI), serum insulin, and blood glucose were studied in six patients with chronic pancreatitis and six matched controls.asal PGLI levels were significantly higher in the patients, despite higher fasting glucose concentrations. Tolbutamide infusion had no significant effect on mean PGLI levels in controls but was associated with significant elevation in pancreatitis patients, despite higher circulating glucose levels in the latter. The data suggest that chronic calcific pancreatitis patients hypersecrete immunoreactive glucagon, possibly from a nonpancreatic source and that this immunocreactive material may be stimulated by sulfonylureas.

Adult↗