Biomedical subjects

M Pati

Publications and source records attributed to M Pati.

3 recordsLinked to original sources

PubMed2004

Sonographic biometrical range of external genitalia differentiation in the first trimester of pregnancy: analysis of 2593 cases.

OBJECTIVES: The aim of this study was to establish the accuracy of fetal gender assignment by sonography in the biometrical range of 18 to 29 mm of biparietal diameter (BPD). METHODS: Transvaginal and/or transabdominal sonography was used to detect the sagittal sign as a marker of fetal gender in 2593 fetuses with BPD between 18 and 29 mm. The results of sonographic examination were compared with the gender at birth or with karyotype obtained from amniotic fluid cells or chorionic villus sampling. RESULTS: Fetal gender assignment was feasible in 2374 of 2593 cases (91%). Of the 2188 fetuses with known fetal sex outcome, 1025 were males and 1157 were females, and 6 had genital anomalies. In fetuses without genital anomalies, an accuracy rate of 100% was achieved at a BPD of >/=24 mm. The results of the six cases with genital malformations were considered separately. CONCLUSION: Sonography is a reliable method for the study of the morphological development of the external genitalia in fetuses 'in vivo'; it is possible to assign fetal gender in 95 to 99% starting at a BPD of 20 mm and to achieve an accuracy rate of 99 to 100% from a BPD of 22 mm, but fetal sex assignment should not be undertaken below a BPD of 22 mm, and especially not in cases where fetal sexing affects pregnancy management.

Amniotic Fluid↗

PubMed1994

[Medullary carcinoma of the thyroid: a case of multiple endocrine neoplasia type 2A].

Medullary thyroid carcinoma (MTC) is a neoplasm derived from thyroid C-cells. It can appear under different variants; in the 20-30% of the cases, it's a familial variant. Nevertheless, the MTC appearing in MEN 2-A has a better prognosis compared to MEN 2-B. Usually, the diagnosis of MEN 2-A is done at the age of 20, and frequently (in the 50% of the cases) these patients develop, in a second time, adrenal hyperplasia and/or pheochromocytoma. The case we are talking about, concerns a patient of 49 years old, who came to our observation with a history of bilateral adrenalectomy for pheochromocytoma. What attracted our attention was the presence, in his family, of a brother, who died from pheochromocytoma, and the mother, died for a MTC. During the admit in our section, the patient has undergone a screening for the thyroid function, also if there wasn't a sign or symptom of interest of the gland. It has been possible to single out some nodular formations that, together with the high value of the calcitonin found, allowed the diagnosis of MTC. It has been very important to make diagnosis of MEN 2-A because we can introduce the patient and his family to a program of screening to precociously single out the presence of the typical signs of this pathology. In MEN 2-A a precocious diagnosis allows to sensibly improve the prognosis.

Adrenal Gland Neoplasms↗

PubMedDate not supplied

Empty sella and headache.

Empty sella is an anatomical condition caused by herniation of the subarachnoid space into the pituitary fossa through an incompetent sellar diaphragm. Headache seems to be one of the most frequently reported symptoms. We studied 13 headache patients (12 females, 1 male) presenting with primary empty sella (PES) on CT scan. The characteristics of the headache were analyzed and plasma levels of pituitary hormones or cortisol assessed. We confirmed the nonspecific nature of the headache in PES even though the majority of our patients complained of daily headache, mostly localized anteriorly. Hormone plasma levels were within normal range in all the patients assessed. However, four patients reported earlier endocrine disorders and more than half of the patients presented with obesity. In our opinion, PES should be suspected in middle-aged overweight women with daily headache even in the absence of endocrine symptomatology.

Adolescent↗