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Biomedical subjects

M Pasqualini

Publications and source records attributed to M Pasqualini.

45 records · Page 3Linked to original sources
PubMedDate not supplied

[Intraoperative use of radiofrequency thermoablation of liver tumors: considerations on indications and related therapeutic aspects].

PURPOSE: To evaluate the usefulness of intraoperative radiofrequency thermoablation of liver tumours in association or not with hepatic resection. MATERIALS AND METHODS: 21 patients were treated between January 1998 and December 2001, there were 4 hepatocellular carcinoma and 17 metastasis. In 13 cases radiofrequency was associated to hepatectomy, in 3 cases to resection of extraepatic disease and in 5 cases were performed alone. 23 lesions were treated by radiofrequency (range 1-3); the mean dimension was 26 millimetres (range 8-70). A clamping of the liver pedicle was always done. RESULTS: There were no operative deaths, 3 (14.3%) patients developed complications related to radiofrequency (2 biliary leakages, 1 hepatic abscess). 14 (66.7%) patients were alive after a mean follow up of 14.5 months, 2 of all (9.5%) had a recurrence in the site previously treated with thermoablation. Association between hepatectomy and radiofrequency increased the number of curative liver resections from 10.1% to 16.3% (in case of colorectal metastasis). DISCUSSION: Intraoperative radiofrequency is useful to increase the number of curative hepatectomies, to treat liver masses which demonstrate unresectable or found by ultrasonography at the operating time and even to reach tumours difficult to manage by percutaneous approach. In any case the aim is to obtain the absence of macroscopic neoplastic disease (RO status). It is a safe and effective therapeutic strategy, anyway all procedures and indications are still not completely cleared. CONCLUSIONS: Intraoperative thermoablation of liver tumour is safe and effective and increases therapeutic the number of curative hepatectomies. Further progresses may improve the efficacy and extend the indications of this strategy.

Adult↗
PubMedDate not supplied

[Atypical presentation of angiomiolypoma in a patient with peritoneal metastases from ovarian cancer: a case report].

A renal mass with not typical instrumental characteristic in patient in follow-up for ovarian neoplasia sets to the surgeon serious doubts about proper surgical strategy. Achieve of the conservative renal surgery assisted by the intraoperative use of the radiofrequency energy has allowed to preserve the renal function and the diagnosis of unknown angiomyolipoma.

Adenocarcinoma, Papillary↗
PubMedDate not supplied

Radiofrequency ablation of liver tumours with transpleurodiaphragmatic access.

Radiofrequency thermoablation (RFA) is used to treat unresectable liver tumours. RFA is performed using an abdominal access (laparotomic, laparoscopic and percutaneous). A transpleurodiaphragmatic approach has recently been proposed, particularly for the treatment of tumours which are placed near to inferior vein cava and hepatic veins and which are difficult to reach for an abdominal access. A patient with a liver metastasis of the segment VIII underwent RFA with an associated wedge resection of the segment VII, both were performed with a transthoracic access. Peri- and postoperative complications did not occurred. The patient was discharged on fifth postoperative day, and she is disease free after a follow up of 6 months. A transpleurodiaphragmatic access can be considered a safe and efficacy procedure to perform an RFA of a liver tumour in selected cases.

Catheter Ablation↗
PubMedDate not supplied

Radiofrequency thermal ablation of hepatocellular carcinoma: our five year experience.

PURPOSE: We describe our experience in the multimodal treatment of HCC patients both using the PRFTA and IRFTA treatment associated or not with hepatic resection, valuating the feasibility, the complication, length of hospital stay and survival rate of selected HCC patients. MATERIALS AND METHODS: Between March 1998 and January 2004, 53 HCC patients undergoing PRFTA and IRFTA treatment. We describe 41 patients with monofocal disease and 12 patients with multifocal disease: in this last group 7 patients had unilobar involvement while 5 patients had multilobar tumour. RESULTS: We reported patients underwent RFTA because not candidates to surgical procedures and patients underwent liver resection and open radiofrequency treatment associated. We successfully used percutaneous and intraoperative approach being the last one significantly advantageous in lesions greater than 5 cm, multiple bilobar tumours and tumours close to the hilum and major vessels: the laparotomic approach permitted the temporary occlusion of the vascular inflow allowing Pringle manoeuvre. DISCUSSION: Hepatocarcinoma still represent one of the major causes of cancer related death worldwide. Systemic therapeutic agents and locoregional agents are rarely correlated to complete response and usually associated to high toxicities: the potentially curative or palliative benefit of RFTA in non surgical candidates improve overall patients survival significally better then the chemotherapy regimens. CONCLUSION: RFTA appears to have several advantages, which also include a reducing in morbidity, a shortening of the hospital stay and good response to patients requirement in term of enduring pain.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

[Primary intrahepatic calculosis: hepatic lithotomy or hepatectomy?].

The authors discuss about the different surgical approaches in the management of primary intrahepatic stones, conforming their experience to literature reports. In the future they hope for a more conservative treatment on the basis of the good results obtained with percutaneous transhepatic fiber cholangioscopy (P.T.C.S.) and ultrasonographic extra-body lithotripsy recently adopted in the clinical practice.

Adult↗
PubMedDate not supplied

The Miller-Galante knee prosthesis system: a review of 42 cases.

The authors report their experience in 42 total Miller-Galante knee prostheses; 40 of the prostheses have an average follow-up of 25 months (minimum 9, maximum 55). Based on the Hungerford-Kenna clinical evaluation system, 59% of the patients obtained excellent results, 26% good results, 10% fair results, and 5% poor results. Radiographically, there were no cases of loosening of the implant. The joint axis was always well-corrected. A total of 12% of the patients complained of patellar pain (3 cases without either a prosthesis or keiloplasty; 2 cases with a patellar prosthesis). Overall, 85% of the patients obtained excellent or good results.

Aged↗
PubMedDate not supplied

Should total prosthetization of the patella be used in knee surgery? A review of the literature and personal experience.

Based on an analysis of patellar complications during total knee arthroplasty, the authors report the conclusions of the most important studies in the literature as to whether or not the patella should be prosthetized. In particular, several important parameters to be taken into consideration before performing patellar prosthetization are discussed: the conditions of the cartilage and of the patellar bone, preoperative clinical symptoms, age, habits, body weight of the patient. The results of 50 Miller-Galante prostheses implanted between January 1989 and September 1993 is reported. The patella was prosthetized in 40% of the cases; there were no fractures or vascular necroses, nor was there breakage or detachment of the prosthetic button. Patellar pain was manifested in 5 cases (10%), 2 of which with a prosthetized patella, including 1 case of external dislocation and 1 case of breakage of the patellar tendon; another case of external dislocation, in a non-prosthetized patella, was clinically asymptomatic; pain was manifested after delay in wound healing in 2 cases. Only one patient with breakage of the patellar tendon was submitted to further surgery. The authors conclude that in light of the numerous studies published prosthetization of the patella may offer overall better clinical results, but they advise that indications should be carefully evaluated for each individual case, and that details in surgical technique should be observed (correct execution of bone resection and of lateral release when necessary, preservation of Hoffa pad, accurate hemostasis).

Adult↗