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Biomedical subjects

M Pasino

Publications and source records attributed to M Pasino.

42 records · Page 3Linked to original sources
PubMed1976

Peptichemio in children with neoplastic disease.

32 children with different types of tumors have bben treated with peptichemio. The efficacy was excellent in rhabdomyosarcoma and embrional sarcoma; encouraging in neuroblastoma, Wilms tumor and histiocytosis X. Side and toxic effects were minimal. In conclusion we can say that peptichemio is effective in oncologic diseases, but a larger number of patients is required in order to have a better knowledge about the antitumor activity of this drug.

Child↗
PubMed1975

Properties of lymphocytes in chronic HBAg-positive hepatitis. An approach to pathogenetic problems.

Lymphocytes from 22 children affected by chronic hepatitis were studied and a comparison was made with a control group of 32 healthy children in the same age range with respect to PHA dose-response curves. E-rosette formation and membrane immunoglobulin (Ig). From the results it appeared that PHA dose-response curves were displaced to the left (low PHA dose), DNA synthesis was significantly higher for all PHA dosages tested, and that the plasma of chronic hepatitis patients acted neither as inhibitor nor stimulator. The percentage of E-rosette-forming cells decreased, but the total number was normal. The mean percentage of Ig-bearing cells was normal but the single values were spaced over a wide range. It can be assumed that, at least in the chronic stage, there is an enhanced response to PHA and an increased percentage of cells without markers either for T or for B cells.

Antibody Formation↗
PubMedDate not supplied

A short-term in vitro drug sensitivity assay in pediatric malignancies.

A short-term in vitro chemosensitivity test has been applied to 131 specimens from 109 children with various malignancies. The clinical outcome was correlated with in vitro percentage inhibition (PI) of DNA synthesis by the drug tested. In 62 correlations, PIs of responsive and of resistant patients differed significantly, with a cut-off value of 37%. The test predicted clinical resistance in 53/54 cases, with a specificity of 98%, and clinical response in 8/8 cases, with a sensitivity of 100%. This test can be useful particularly in predicting chemoresistance in relapsing patients, to avoid unnecessary toxicity.

Child↗