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Biomedical subjects

M Paris

Publications and source records attributed to M Paris.

116 records · Page 7Linked to original sources
PubMedDate not supplied

Cardioprotective effect of trimetazidine during coronary artery graft surgery.

Reperfusion injury remains the most uncontrolled phenomenon during cardiac surgery. Potential myocardial protection by trimetazidine was tested in a double blind placebo controlled study on 19 patients undergoing aorto-coronary bypass surgery. The trimetazidine group was composed of 10 patients and the placebo group of 9 patients. Pretreatment was started three weeks before surgery with 1 tablet (trimetazidine 20 mg) t.i.d. and the same drug was added to the cardioplegic solutions (trimetazidine: 10(-6) M). The cross clamping time was 41.1 +/- 3.8 minutes in the trimetazidine group and 39.8 +/- 2.3 minutes in the placebo group. Metabolic measurements showed that the increase of malondialdehyde measured in the coronary sinus 20 minutes after reperfusion was significantly (p = 0.014) less in the trimetazidine group (from 1.60 +/- 0.11 to 1.79 +/- 0.2 mumol/L-1) than in the placebo group (from 1.17 +/- 0.11 to 2.84 +/- 0.58 mumol/L-1). Myosin was present 4 hours after surgery in all patients in the placebo group and in 5 of the 10 of the trimetazidine group (p = 0.036). Haemodynamic measurements showed that patients pretreated with trimetazidine had a better ventricular function, as assessed by the stroke work index (SWI) significantly (p = 0.01) higher in the trimetazidine group (0.0391 +/- 0.0029 g/min/m2/beta) than in the placebo group (0.0282 +/- 0.0026 g/min/m2/beat), the evolution of SWI during surgery was not significantly different between the two groups. Thus trimetazidine seems to reduce ischaemia-reperfusion damage during cardiac surgery; moreover pretreatment with trimetazidine allows the patient to face the operation with better ventricular function.

Blood Transfusion, Autologous↗
PubMedDate not supplied

[Immunofixation in agarose gel for the identification of monoclonal immunoglobulins].

Immunoelectrophoresis is the usual method for identifying abnormal bands detected by zone electrophoresis. In the last few years, a new technique has appeared, that of immunofixation. This method involves an antibody-antigen precipitation reaction in an electrophoretic strip. The aim of the present study was to compare immunofixation (IFX) and immunoelectrophoresis (IEP) of 101 sera with one or more homogeneous bands upon serum protein electrophoresis: among them 97 bands were subsequently characterized by IFX on agarose gel, and only 50 by IEP. IF appears to be a more sensitive technique for characterizing M-components, especially those with multiple bands. While more rapid than IEP, this new procedure does not seem appropriate for routine use.

Blood Protein Electrophoresis↗
PubMedDate not supplied

[The effect of prostaglandins E1 and F1 alpha and indomethacin on haemodynamic and renal endocrine and exocrine function (author's transl)].

1. The PGE1, infused into the renal artery of the dog, increased RPF, Sodium and Potassium excretion rate and UV; it diminished the EPAH and FF but did not alter GFR and PRA. 2. The indomethacin, injected IV, in an other group of animals, decreased RPF, GFR, Sodium and Potassium excretion rate and PRA, and it increased the EPAH and FF. The administration of the PGE1, inversed the results obtained by indomethacin except those of PRA. 3. The infusion of the PGF1a, in other groups of dogs, did not alter either before or after the administration of indomethacin the parameters measured. 4. It was suggested that 1) neither the PGE1 nor the PGF1a stimulated renin synthesis, in the conditions that our experiments took place. The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.

Animals↗