Chronic severe stress (CSS) and chronic mild stress (CMS) affect the properties of [3H]5,7-dichlorokynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine/NMDA sites in the rat cerebral cortex. Specifically, CSS decreases, while CMS increases, the potency of glycine to displace [3H]5,7-DCKA binding to glycine/NMDA sites. Moreover, in both models, a reduction of the specific [3H]5,7-DCKA binding was observed. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression.

Animals↗

PubMedDate not supplied

Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.

The aim of our study was to investigate the level of metabotropic glutamate receptors (mGluRs) in the brains of rats after chronic mild stress. Using Western blotting procedure we showed that the level of mGluR5 receptor protein was increased in CA1 and decreased in CA3 region of the hippocampus. Our results indicate that mGluR5 can possibly be engaged in the mechanism of depression.

Animals↗

PubMedDate not supplied

Effects of anxiolytic drugs on some behavioral consequences in olfactory bulbectomized rats.

The present study was designed to evaluate the effects of bulbectomy and acute administration of anxiolytic drugs (diazepam, 10 mg/kg; chlordiazepoxide, 10 mg/kg) on the behavior of both sham-operated and olfactory bulbectomized rats in two tests predictive of anxiolytic activity: plus-maze test and Vogel's conflict test. We investigated also the effect of flumazenil (10 mg/kg), a benzodiazepine receptors antagonist, both on control and drug-treated animals. We also evaluated behavior of animals in conditioned place aversion procedure. Our results show the decreased level of anxiety in bulbectomized animals comparing with sham-operated rats. Anxiolytic drugs further deepen this effect.

Animals↗

PubMedDate not supplied

The effect of kainic acid administration into globus pallidus on EEG and behavior of rabbits.

Injection of 0,5 microgram of kainic acid into the globus pallidus of rabbits carrying chronically implanted electrodes and cannulas, resulted in an increase of cerebral electrical activity up to appearance of epileptoidal discharges. These effects were prevented by diazepam pretreatment. Behavioral changes produced by kainic acid were biphasic; ipsilateral rotations or postural asymmetries, observed in the early phase, gave way later to contralateral asymmetries. Kainic acid facilitated sniffing episodes, which appeared simultaneously with epileptoidal discharges in the hippocampus. The stimulation of globus pallidus neurons with kainic acid resulted also in electrical activation of the ventral anterior thalamic nucleus. The results indicate that the majority of the neurons of globus pallidus display selective sensitivity to kainic acid and that the globus pallidus is functionally connected with the hippocampus and the ventral anterior thalamic nucleus.

Animals↗

PubMedDate not supplied

[Acinar and enzymatic, vascular and inflammatory, lymphatic and interstitial factors in the induction of acute necrosis of the pancreas].

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Acute Disease↗