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Biomedical subjects

M Pakarinen

Publications and source records attributed to M Pakarinen.

23 records · Page 2Linked to original sources
PubMed1987

Tarsorraphy in the treatment of persistent corneal lesions.

Altogether 38 tarsorraphies were carried out to 19 patients with corneal epithelial defects resistant to conventional therapy. The main operative indications were lagothalmos, dry eyes and inadequate blinking (6 patients). Corneal ulcer was detected in 17 eyes, six of which perforated. All patients had been treated from one week to 16 months (mean 3.5 months) without healing. Retarsorraphy was needed in 6 eyes. In perforations tarsorraphy was combined to tissue adhesive (3 eyes) or to therapeutic contact lens (4 eyes) or to conjunctival flap (2 eyes). The corneal epithelium healed in all except 2 cases (one perforation, one ulcer that is slowly improving). Five of the 6 perforations could also be cured without grafting. One eye of a severely debilitated patient was treated with a Gundersen's conjunctival flap and total tarsorraphy, but remained hazy. We consider, that tarsorraphy is valuable in treating corneal lesions due to lagophthalmos, dry eyes or disturbed lid function. It can also be used in threatening of manifest corneal perforation, if combined with the use of tissue adhesive or therapeutic contact lens.

Adolescent↗
PubMedDate not supplied

Brush cytology in the course of acute small bowel allograft rejection.

OBJECTIVE: To examine the changes in brush cytology during acute small bowel allograft rejection and to evaluate the usefulness of cytology in detecting acute rejection. STUDY DESIGN: Heterotopic porcine small bowel allografts were followed by brush cytology and full-thickness biopsies during unmodified rejection. RESULTS: The most prominent changes in cell differential counts were an increase in the proportion of granulocytes and decrease in the proportion of epithelial cells. In brushed epithelial fragments, infiltration of granulocytes and acidophilia increased, and cell cohesion was gradually lost with the degeneration of nuclei and necrosis of epithelium. The cell differential count was compared to the histologic acute rejection index, which was created on the basis of five semiquantitatively evaluated histologic parameters. The sensitivity of cell differentiation in detecting histologically moderate or severe rejection was 87% (13 of 15 cases) and the specificity 76% (5 false positives in 21 negative cases). CONCLUSION: Suspicion of acute rejection can be assessed with reasonable reliability by cytology, but it cannot be detected earlier than by histology. Brush cytology complements mucosal biopsies in the evaluation of rejection and, as a rapid and cost-effective method, may even partly replace them. It may also prove valuable in detecting opportunistic bowel infections in immunosuppressed patients.

Animals↗