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Biomedical subjects

M P Shepherd

Publications and source records attributed to M P Shepherd.

15 recordsLinked to original sources
PubMed1985

Multiple primary pulmonary malignancy.

The diagnosis of multiple primary pulmonary malignancy can be difficult; and the criteria for such tumours may arise simultaneously or consecutively, be unilateral or bilateral and have similar or different histology. Resection remains the treatment of choice and, despite the gloomy outlook, no patient should be assumed inoperable. To achieve early diagnosis of a consecutively occurring tumour, regular and prolonged follow up of every patient who has had a first tumour resected is recommended.

Carcinoma, Bronchogenic↗
PubMed1983

The surgeon's use of the rigid and flexible bronchoscopes in the diagnosis of bronchial carcinoma.

The results of a prospective study comparing the rigid and flexible fibreoptic bronchoscopic techniques in the diagnosis and assessment of bronchial carcinoma are reported. One hundred and nine patients underwent fibreoptic bronchoscopy and these were compared with a similar group of 111 patients in whom the rigid bronchoscope was used. Bronchoscopic diagnosis of malignancy was achieved in 73.4% of patients in the fibreoptic group and in 73% using the rigid bronchoscope.

Biopsy↗
PubMed1982

Endobronchial metastatic disease.

Between 1969 and 1979, 90 patients of the Thoracic Surgical Unit at Harefield Hospital were found to have pulmonary metastatic disease. In 25 instances (28%) the diagnosis was established by bronchial biopsy. Twenty-four patients had endobronchial metastatic carcinoma and in one metastatic sarcoma was diagnosed. All but one had a past history of malignancy, the interval between treatment of the primary and appearance of the endobronchial metastasis ranging from a few months to 17 years. Primary sites in these patients included large intestine, breast, cervix, uterus, and bladder. There were four instances of metastatic malignant melanoma. The pulmonary secondaries were resectable in 10 patients and in one a second resection was done for a further metastasis three years after the first. Three patients are still alive two, four, and 10 years later.

Adenocarcinoma↗
PubMed1982

Thoracic metastases.

One hundred and four patients are reviewed who were found to have thoracic metastases arising from distant primaries. Ninety lesions were intrapulmonary and the remainder involved other thoracic structures, such as chest wall and pleura. The tissue diagnosis was established in all but eight patients. Cases were included only if review of the histology revealed that both primary and secondary tumours were identical. The chest lesion was the presenting feature of the disease in 21 patients. In the remainder, the interval between treatment of the primary and appearance of the thoracic metastasis varied from a few months to 25 years. Twelve patients had metastatic sarcoma. The remainder had metastases from the gastrointestinal tract (29), from the genitourinary tract (32), from breast primaries (18), and a miscellaneous group (13) which included five instances of malignant melanoma and metastases from adrenal, laryngeal, and thyroid primaries. The metastases were treated surgically in 47 patients. In the light of cell type, availability of nonsurgical methods of treatment, site of metastasis, and survival, an attempt is made to evaluate the place of surgery in the management of thoracic metastatic disease.

Adenocarcinoma↗