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Biomedical subjects

M P Ruben

Publications and source records attributed to M P Ruben.

At least 19 recordsLinked to original sources
PubMed1993

Melanin repigmentation after gingivectomy: a 5-year clinical and transmission electron microscopic study in humans.

The epithelium-melanin unit is formed by the melanocytes and keratinocytes. There is little information available about the behavior of melanocytes after surgical injury. Five white patients with comparable gingival pigmentation underwent gingivectomy to remove bandlike melanin pigmentations for cosmetic reasons. Biopsy specimens were taken from gingivectomy sites and healing areas 2, 3, 6, 7, 15, 50, and 180 days and 1.5, 3, and 5 years after the procedure. Transmission electron microscopic study revealed melanocytes in the process of migration and undergoing mitosis 6 and 7 days postoperatively. These cells exhibited, in the 15-day specimens, renewal of their dendritic processes and the four different stages of melanosome development. Keratinocytes were devoid of pigmented material until 50 days postoperatively. Clinically, the intensity of the pigmentation varied among the patients. Two reached baseline coloration 1.5 years postsurgery, while three returned to baseline coloration by 3 years postsurgery. Thus, gingival resective procedures, if performed solely for cosmetic reasons, offer no permanent results. (Int J Periodont Rest Dent 1993; 13:85-92.)

Adult↗
PubMed1988

The laterally positioned flap.

The laterally positioned flap has shown itself to be the most predictable and esthetically successful procedure in the treatment of mucogingival defects such as gingival/periodontal recessions and root exposures. It is of utmost importance that the biologic principles of wound healing, which have been discussed in the literature and this article, should be adhered to prior to, during, and after the surgical procedure.

Animals↗
PubMed1986

Periodontal probing.

Explore the source record for details and available documents.

Epithelial Attachment↗
PubMed1981

Topography of root surfaces treated in vitro with citric acid, elastase and hyaluronidase. A scanning electron microscopy study. Part II.

Sixteen extracted human teeth were separated into two groups, root planed, and treated with either elastase or hyaluronidase following acid demineralization. The duration of enzyme application varied from 5 to 20 minutes. From scanning electron micrographs the following was concluded: (1) The cemental collagen network is composed of previously described extrinsic and intrinsic fiber systems. (2) Root planing, using tactile sense as the final criteria, does not always result in complete elimination of contaminants. (3) Citric acid (pH = 1), applied for 3 to 4 minutes, is an effective means of exposing cemental collagen. (4) Qualitatively, the enzyme treatment subsequent to acid demineralization seemed to result in more effective exposure of the collagen mantle of cementum. (5) Further definitive research must be done to determine, both the usefulness of enzymatic treatment in vitro and in vivo and the optimum enzyme concentrations and duration of application.

Adult↗
PubMed1980

Root surface--soft tissue interface. Part I: A review.

A review of the literature is presented with regards to the soft tissue-root surface interface. The basic biological aspects are discussed followed by reports on healing after periodontal surgery. The effect of citric acid, to enhance new attachment, is reviewed in detail. Articles reporting on clinical findings, ultrastructural observation (TEM and SEM), and light microscopic studies have been selected to present the reader with a logical overview of what has been reported in the literature.

Animals↗