Biomedical subjects

M P Morichelli

Publications and source records attributed to M P Morichelli.

2 recordsLinked to original sources

PubMed1984

Morphofunctional findings in adenocarcinoma of endometrium.

Ten cases of adenocarcinoma of the endometrium were studied using histochemical methods for mucopolysaccharides and immunocytochemical methods for the localization of various markers, such as EMA (epithelial membrane antigen), GCDFP-15 (gross cystic disease fluid protein) and CEA. Four cases appeared to contain High Iron Diamine-positive substance and 6 cases were positive using an immunocytochemical method with a polyclonal anti-CEA antiserum. In contrast, no cases stained when a monoclonal anti-CEA antiserum was employed. This suggested that HID- positive material could be a sign of differentiation towards cells with a secretory function.

Adenocarcinoma↗

PubMed1984

Morpho-functional changes in normal cyclic endometrium.

Eight cases of normal endometrium in the early proliferative phase and an equal number of cases in the late secretive phase were stained histochemically for acidic mucosubstances and immunocytochemically for epithelial membrane antigen (EMA), carcinoembryogenetic antigen (CEA) and Gross Cyst Disease Fluid Protein -15 (GCDFP-15) production. Alcian blue positive material was observed in both phases of the cycle, although the distribution was different. Sulphated mucosubstances were only present in the secretive phase. No CEA nor GCDFP-15 immunoreactive material was detected. EMA positive staining was observed in all cases, but the distribution varied according to the two different phases of the cycle.

Adult↗