Papillary and solid epithelial neoplasm of the pancreas.
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Adult↗
Biomedical subjects
M P Kumarasinghe
Publications and source records attributed to M P Kumarasinghe.
Necrotising lymphadenitis of Kikuchi and Fijimoto in Sri Lanka.
We present the clinicopathological features of 10 patients with Kikuchi's lymphadenitis. It is important to distinguish this unusual form of necrotising lymphadenitis, both clinically and histologically, from lymphoma and infective lymphadenitis, including mycobacterial infection. The 10 lymph node biopsies studied were from young adults (9 women) with fever, cervical lymphadenopathy and elevated ESR. This is the first documentation of this condition in Sri Lanka. This benign self-limiting condition can be mistaken for lymphoma or infective lymphadenitis.
Adolescent↗
Atypical presentations of pulmonary tuberculosis diagnosed by fibreoptic bronchoscopy.
A total of 356 patients were subjected to fibreoptic bronchoscopy from September 1989 to June 1991 to exclude bronchial carcinoma. Bronchial biopsy, bronchial brush smears and bronchial wash were obtained. Bronchial wash was examined for acid fast bacilli (AFB) compatible with Mycobacterium tuberculosis. The total number diagnosed as pulmonary tuberculosis by fibreoptic bronchoscopy was 21(5.8%). The sputum smears were negative for AFB in all these patients. Previous studies have shown the importance of fibreoptic bronchoscopy in suspected cases of tuberculosis where the sputum smear is negative. This study is further evidence of the importance of routine examination of bronchial wash for AFB in all cases undergoing fibreoptic bronchoscopy to detect atypical cases of pulmonary tuberculosis.
Bronchoalveolar Lavage Fluid↗
Aspiration cytology of breast lumps.
The results of 287 aspirations performed on palpable breast lumps over a period of 20 months are presented. This is the first documentation of a Sri Lankan experience of this technique. The cytological assessment showed 52 malignant, 149 benign, 8 atypical, 6 suspicious and 72 inadequate aspirates. All lesions with a cytological diagnosis of malignancy were confirmed by histological assessment (False positives = 0). Histological follow up in 96 of the 149 cytologically benign lesions showed that 2 were malignant, giving a false negative rate of 2.1%. Three atypical lesions (37.5%) and four suspicious (66.2%) and 10 inadequate aspirates (13.7%) were also malignant.
Biopsy, Needle↗
Granulomatous mastitis--a well defined entity.
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Adult↗
Cytomorphologic features of diffuse sclerosing variant of papillary carcinoma of the thyroid. A report of two cases in children.
BACKGROUND: Diffuse sclerosing papillary carcinoma (DSPC), a variant of papillary carcinoma of thyroid, needs to be differentiated from classical papillary carcinoma and other variants. This variant is characterized by diffuse involvement of one or both thyroid lobes showing such histologic features as prominent sclerosis, an intense lymphocytic infiltrate, numerous psammoma bodies and squamous metaplasia together with the characteristic cytoarchitectural pattern of classical papillary carcinoma. Histologic and immuno-histochemical features have been described in previous publications. Although cytologic features of several variants of papillary carcinoma have been described previously, those of DSPC have not been widely published. The present report is on the cytomorphologic pattern of DSPC in two children, further highlighting the special features. CASES: A boy, aged 11 years, presented with diffusely nodular, firm enlargement of the thyroid gland with many palpable lymph nodes, and a girl, aged 12 years, presented with diffusely nodular, firm enlargement of the left lobe with a prominent nodule on the lower pole. Fine needle aspiration biopsy (FNAB) smears stained with hematoxylin and eosin showed numerous psammoma bodies, many lymphocytes, metaplastic squamous cells and absent stringy colloid together with epithelial cells showing classical features of papillary carcinoma, such as nuclear grooves, intranuclear inclusions and papilloid structures. Histologic examination of the thyroidectomy specimens showed features of diffuse sclerosing variant of papillary carcinoma. CONCLUSION: A diagnosis of DSPC should be considered when a combination of clinicocytologic features consisting of numerous psammoma bodies, lymphocytes, squamous metaplasia and absence of stringy colloid are noted with otherwise typical cytoarchitectural features of papillary carcinoma in FNAB smears obtained from diffusely nodular, firm thyroid enlargement.
Biopsy, Needle↗
Cytology of granulomatous mastitis.
OBJECTIVE: To examine the cytologic features of granulomatous mastitis. STUDY DESIGN: Cytologic features of granulomatous mastitis (GM) are described as found on retrospective analysis of hematoxylin and eosin (H&E)-stained smears of nine breast lesions: eight fine needle aspiration biopsies and one imprint smear. All nine lesions were histologically confirmed. RESULTS: The aspirates were moderate or abundant. The H&E smears showed a distinctly inflammatory background with multinucleated giant cells (both foreign body and Langhans type), debris, neutrophils, macrophages, epithelioid cells and reactive epithelial cells. Special histochemical stains did not reveal any specific organisms. No foamy cells or caseation was seen. The four patients who presented for follow-up were free of disease after a minimum of 6 and maximum of 38 months. CONCLUSION: Although there are many entities mimicking GM, the cytologic pattern--consisting of multinucleated giant cells, debris, neutrophils, macrophages, epithelioid cells and reactive epithelial cells in the absence of foamy cells, caseation and demonstrable organisms--should prompt a diagnosis of GM.
Adult↗
Itraconazole pulse therapy in chromoblastomycosis.
Although daily itraconazole has been used effectively in chromoblastomycosis, there is no record of pulse therapy for chromoblastomycosis. A 68-year-old woman with a history of slowly enlarging scaly plaque involving the left shoulder and lateral chest, presented to the dermatology clinic at General Hospital, Kalutara, Sri Lanka. Clinically chromoblastomycosis was suspected. Direct KOH smears showed sclerotic bodies and histology showed granulomata with characteristic brown spores. Itraconazole (Sporanox) 200 mg. b.i.d. orally was given for a week followed by 3 drug free weeks. This cycle was repeated for 6 months (i.e. 7 pulses). Clinical improvement was visible by 2 months. Scrapings and biopsy repeated 5 months after the commencement of treatment were negative for chromoblastomycosis. The lesion had clinically healed by 5 months. Examination 8 months after cessation of treatment did not show any recurrence. Itraconazole pulse therapy is cheaper than daily treatment but effective in chromoblastomycosis. The optimal dosage and end point of treatment need to be ascertained after a larger study.
Administration, Oral↗