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Biomedical subjects

M P El'shanskaia

Publications and source records attributed to M P El'shanskaia.

At least 19 recordsLinked to original sources
PubMed1991

[Effects of non-clostridial anaerobic infection on the course of chronic pulmonary tuberculosis in experimental animals].

Influence of non-clostridial anaerobic infection on the course of chronic pulmonary tuberculosis caused by intrapleural administration of BCG used in a vaseline-lanolin mixture was studied experimentally on guinea pigs. Administration of Bacteroides fragilis in the presence of a mild tuberculous inflammation aggravates the course of a specific process promoting pleural empyema development, increase in the size of pulmonary granuloma, extension of pathologic changes into the parenchymatous organs and aggravation of a nonspecific inflammatory reaction. Animals with mixed infection exhibited a longer duration and higher level of M. tuberculosis and B. fragilis excretion than those having a mono-infection. The findings suggest M. tuberculosis and B. fragilis synergism.

Animals↗
PubMed1989

[The etiologic significance of ultrafine forms of the causative agent of tuberculosis in the development of sarcoidosis of the respiratory organs].

Pathological material, i. e. bronchoalveolar lavage fluid (BALF) and blood plasma from patients with various pathological processes in the lungs was studied. Eighty seven patients with sarcoidosis of the respiratory organs were subjected to complex microbiological investigation and ultrasmall forms of tubercle bacilli were detected in BALF of 67 (77 per cent) of them. Histological examination revealed alveolitis and granulomas of lymphoid-macrophagal nature in the lungs of the experimental animals exposed to the material from the sarcoidosis patients.

Female↗
PubMed1988

[Dynamics of the shedding of bacterial and ultrafine forms of mycobacteria during the chemotherapy of patients with pulmonary tuberculosis].

The specific features of bacterial excretion by patients with pulmonary tuberculosis in the process of chemotherapy, depending on the duration of treatment, have been studied, and the time-course of the excretion of ultramicro forms of mycobacteria by patients with and without caverns in the lungs in the process of chemotherapy has been followed. The results of the detection of M. tuberculosis ultramicro forms with the use of the biological and bacteriological methods indicate that both these methods are highly effective and informative. The method of the direct reversion of ultramicro forms into coccoid ones in Shkol'nikova's culture medium with 10% of plasma added has proved to be the simplest. The injection of sputum filtrates containing filter-passing (ultramicro) forms of mycobacteria into experimental animals induced the development of specific minor tuberculous inflammation of a productive character without the caseation of granulomas or progressing; such inflammation coursed as a latent lympho-hematogenous process.

Animals↗
PubMed1982

[Structural changes in the thymus in experimental tuberculosis].

Structural and functional alterations in the thymus in experimental tuberculosis are phasic in nature and involve 2 stages. In the early stage of tuberculous process, the morphofunctional status of cell elements of the blood-thymic barrier increases as vascular permeability and lymphocyte migration rise and the synthesis of epithelial cells of the medulla gets activated. During disseminated tuberculosis cell elements of the thymic parenchyma undergo destructive changes as a result of histohematic barrier impairment leading to disturbed homeostasis and organ alterations. Thymic macrophages develop from monocytes rather than from local cells.

Animals↗
PubMed1980

[Lymphoid cell ultrastructure in experimental tuberculous granuloma].

There are two groups of activated cells differing both in ultrastructure and manifestations of functional activity in lymphoid populations participating in the formation of tuberculous granuloma. In group 1 lymphoid cells, the development of intracellular structure is associated with an intense synthetic and secretory activity. Group 2 cells are mainly characterized by absorption function realized by means of active pinocytosis. The heterogeneity of subcellular organization of lymphoid cells in experimental tuberculosis reflects differences in their functional specialization. Study of tuberculous granuloma lymphocytes by scanning electron microscopy does not allow the lymphocytes to be identified as T and B cells without immunologic marker reactions.

Animals↗