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Biomedical subjects

M P Delporte

Publications and source records attributed to M P Delporte.

7 recordsLinked to original sources
PubMed1976

[Hypoglycemic complications of oral drug therapy of diabetes mellitus. 21 cases].

The authors present 21 cases of severe hypoglycaemic side effects in diabetics treated with oral sulphonylurea drugs, including two deaths. The medications involved the most frequently were glibenclamide followed by glybutamide and glicalzide. Such side effects often occur early and are unrelated to dose. The classical predisposing factors were noted : old age, renal insufficiency, hepato-cellular insufficiency, drug associations -- in particular oral anticoagulants and salicylates. The indications for such drugs in the treatment of diabetes are discussed. Their use seems doubly illogical in the case of late onset obesity diabetes since the latter is accompanied by cardiovascular complications. It is dangerous in the elderly, particularly sensitive to the risks of hypoglycaemia and in who the diagnosis of "diabetes" is too often made on inadequate grounds.

Age Factors↗
PubMedDate not supplied

[Muscular and nervous system manifestations of Graves' disease].

A study of 30 cases of Grave's disease confirmed the frequency of hyperthyroid myopathy, whether obvious or revealed by E.M.G. More than by the association of various symptoms (pretibial myxoedema, antithyroid antibodies), we were struck by the multiple symptoms of Grave's disease with myopathy, which confirms the anglo-saxon concept of the polysystemic nature of Grave's disease. This symptomatic richness is not necessarily proportional to the thyroid hypersecretion, and one may suppose that these patients have a greater peripheral sensitivity to the effects of hormone excess, which would explain the multiple clinical signs. The frequency of neuropathy seemed to us more important than usually believed. The clinical signs are often, or absent, or may be masked by the predominance of muscle wasting. If E.M.G. of the distal muscle and measurement of conduction rates were carried out more often as a routine, this would no doubt permit better assessment of the true frequency of neural involvement.

Electromyography↗
PubMedDate not supplied

[2 new cases of Refsum's disease. Course during diet].

The authors report two cases of Refsum's disease treated with a low phytanic acid and low phytol diet for more than 5 years. The clinical, neurological improvement was undoubted in both cases but it was very gradual, appearing after 10 1/2 and 6 months treatment respectively. During these 5 years, no neurological aggravation occurred in the first patient ; but her sister presented in september 1972, 18 months after she started the diet, a mild attack from which she recovered. On the other hand, the sight and hearing disorders remained unchanged in spite of the considerable fall in phytanemia. In spite of the demanding and unagreeable character of the diet, almost constant moderate diarrhoea, the diet was worth following.

Adult↗
PubMedDate not supplied

[Refsum's disease].

Refsum's disease although rare is of great interest for it may benefit at least partially from treatment. Its clinical diagnosis depends on the association of pigmented retinitis, polyneuritis and cerebellar syndrome. It is confirmed beyond doubt by the increased C.S.F. protein and phytanemia. A full family history is necessary for it is possible to detect heterozygous carriers of the defect by enzyme studies on fibroblast cultures.

Adolescent↗