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Biomedical subjects

M Ott

Publications and source records attributed to M Ott.

130 records · Page 8Linked to original sources
PubMedDate not supplied

Local anesthetic agents--pharmacologic basis for use in obstetrics: a review.

Because of the minimal effects on mother and fetus, regional anesthetic technics are widely employed for labor and delivery. However, the literature describes at least 35 fetal and neonatal deaths and a frightening incidence of fetal distress associated with paracervical block for 1st-stage labor. Continuous lumbar epidural anesthesia for 1st-stage labor has also been associated with fetal distress, but this is minimal and no deaths have been reported. Bupivacaine, a relatively new, long-lasting local anesthetic, is extemely toxic when administered paracervically, but no deaths have been reported with its use for epidural anesthesia. While choice of method and agent must be individualized, continuous lumbar epidural block with bupivacaine appears as effective as and less often dangerous to the fetus than paracervical block.

Anesthesia, Epidural↗
PubMedDate not supplied

Bilateral loss of eighth nerve function as the only clinical sign of vertebrobasilar dolichoectasia.

The case of a 55-year-old female is presented, in whom first a loss of the vestibular and hearing function on the left side occurred with sudden onset, and 3 days later an additional loss of functions on the right side occurred. No other neurological symptoms were present. Angiography and MRI scan revealed vertebrobasilar dolichoectasia with a thrombus attached to the wall of the basilar artery. Anticoagulative therapy improved hearing function on the right side sufficiently to allow conversation. Vestibular organs remained unresponsive to caloric irrigation. This bilateral loss of eighth nerve function is discussed as a rare case of bilateral ischemia of the labyrinthine artery due to basilar dolichoectasia.

Aneurysm↗
PubMedDate not supplied

Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors.

The interaction between glycolysis, glutaminolysis and tumor growth in WAG/Fra rnu/rnu rats has been investigated. Small tumors are characterized by a low conversion of glucose to lactate whereas the conversion of glutamine to lactate is high. In medium sized tumors the flow of glucose to lactate as well as oxygen utilization are increased whereas glutamine and serine consumption are reduced. At this stage the tumor cells start with glutamate and alanine production. Large tumors are characterized by a low oxygen and glucose supply but a high glucose and oxygen utilization rate. The conversion of glucose to glycine, alanine, glutamate, glutamine, and proline reaches high values and the amino acids are released. Pyruvate kinase increases with tumor weight and is positively correlated with an increase in glucose and oxygen utilization. The shift from glutamate consumption to glutamate production is correlated with an increase in glutamate dehydrogenase and glutamate oxaloacetate transaminase activity.

Animals↗