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M Ota

Publications and source records attributed to M Ota.

543 records · Page 31Linked to original sources
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Correlation of immunohistochemical p53 labeling index with inhibition rate in chemosensitivity test in gastric and colon cancer.

To determine whether the expression of p53, p21, bcl-2 or Ki-67 in cancer cells is predictive of chemosensitivity, immunohistochemical examination of these factors and chemosensitivity assays were performed on colon and gastric cancer specimens. Chemosensitivity tests were performed using CDDP, 5-FU, MMC, or ADR and inhibition rate (IR) was calculated by MTT assay. Before exposure to anticancer drugs, the samples were investigated immunohistochemically for expression of the above factors and after anticancer drug exposure by TUNNEL staining, for the presence of apoptotic cells. With 5-FU and MMC, the apoptotic index was well correlated with IR, so their effects were related to apoptosis. Moreover, with these two agents, the p53 labeling index (LI) was inversely correlated with IR and p21-LI showed a good correlation with IR. We therefore concluded that immunohistochemical studies for p53 and p21 were useful for predicting the chemosensitivities of colon and gastric cancer to MMC and 5-FU.

Antineoplastic Agents↗
PubMedDate not supplied

Is hepatic resection for multiple liver metastases from colorectal carcinoma acceptable treatment?

BACKGROUND/AIMS: To determine an appropriate surgical treatment for patients with multiple liver metastases, we evaluated the efficacy of treatment in patients with 5 or more liver tumors in both lobes after metastasis from colorectal carcinoma which we refer to as H3 liver metastasis. METHODOLOGY: Seventy-two cases of H3 liver metastasis were classified as follows into four types according to tumor distribution in the liver: type A (n = 16), multiple metastases present in one lobe, and, in the other, confined to one segment; type B (n = 12), multiple metastases present bilaterally, but with tumors larger than 2 cm in diameter confined to one lobe or to three segments; type C (n = 10), multiple and diffuse metastases present in both lobes and all tumors 2 cm or less in diameter; and type D (n = 34) metastatic tumors larger than 2 cm in diameter occurring in every segment of the both lobes. Hepatectomy was performed within a possible range as a rule for all cases, and intrahepatic arterial infusion was performed in unresectable cases. In cases that responded to intrahepatic arterial infusion, hepatectomy was considered and performed when technically possible and potentially curative. RESULTS: The proportion of cases treated with hepatectomy were: type A, 56.3%; type B, 8.3%; type C, 10.0%; and type D, 2.9%. The regional intrahepatic arterial infusion ratios and response rates to it were 18.8% and 0.0% in type A, 91.7% and 33.3% in type B, 80.0% and 71.4% in type C, and 64.7% and 0.0% in type D, respectively. One type B patient whose tumor showed complete resolution after intrahepatic arterial infusion and one type C patient with a partial response underwent hepatectomy. The cumulative survival rate at two years was significantly lower in type D (3.2%), than in the other types (type A, 33.3%; type B, 36.4%; and type C, 11.7%). CONCLUSIONS: These results suggested that hepatectomy should be performed in cases of type A, and that intrahepatic arterial infusion may be effective as neoadjuvant chemotherapy for type B or C. However, there is no effective treatment for type D at present.

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