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Biomedical subjects

M Ostensen

Publications and source records attributed to M Ostensen.

At least 73 records · Page 4Linked to original sources
PubMed1986

Excretion of gold into human breast milk.

After the administration of 70 mg and 50 mg aurothiomalate, respectively, to 2 patients with rheumatoid arthritis, significant amounts of gold appeared in breast milk.

Adult↗
PubMed1986

Gastrointestinal peptides in serum and synovial fluid from patients with inflammatory joint disease.

The concentrations of immunoreactive vasoactive intestinal polypeptide (ir-VIP), immunoreactive pancreatic polypeptide (ir-PP), ir-somatostatin, and ir-secretin were measured in serum and synovial fluid from patients suffering from various inflammatory joint diseases. One group of patients were not taking any medication, while another group received anti-inflammatory treatment at the time of sampling. High levels of ir-VIP in the synovial fluid were observed in the untreated group of patients, and the concentration of ir-VIP in the synovial fluid was significantly higher than in parallel serum samples. On the other hand, no significant differences in the concentrations of the other peptides were observed either between serum and synovial fluid or between the two groups of patients. It is suggested that VIP is released locally at the inflammatory site and that VIP may be of significance in inflammatory disorders.

Adult↗
PubMed1986

The effect of normal and rheumatic pregnancy sera on intracellular cathepsin B activity in human monocytes.

In a prospective study of pregnant patients with rheumatic disease and healthy pregnant women, the effect of pregnancy serum on human blood monocytes was investigated. Intracellular activity of the collagen degrading enzyme cathepsin B was found to be significantly depressed in monocyte cultures exposed to pregnancy and cord sera, independent of the presence or absence of an inflammatory state in the pregnant woman. Enzyme inhibition developed in a dose-dependent fashion over 3 days in culture. In contrast to cord and pregnancy sera, non-pregnant serum and serum from oral contraceptive users displayed enzyme stimulating activity. The response of monocytes to the stimulating agent carrageenan was unaffected by inhibitory sera. The nature of possible inhibitory factors in pregnancy and cord serum is discussed.

Adolescent↗
PubMed1985

Amyloid-related serum protein (SAA) during and after pregnancy in healthy women and women with rheumatic disease.

The usefulness of amyloid-related serum protein (SAA) as an indicator of disease activity has been evaluated in 11 patients with rheumatoid arthritis (RA), 2 patients with psoriatic arthritis (PA) and 13 patients with ankylosing spondylitis (AS) prospectively studied during and after pregnancy. For comparison, SAA levels were recorded serially during and after pregnancy in 28 healthy pregnant women. SAA levels were unaltered by gestation and thus within the normal range during normal pregnancy, but were raised in healthy pregnant women with episodes of intercurrent infections. In RA and AS patients, SAA concentrations correlated to disease activity during and after pregnancy. Serial levels of SAA and C-reactive protein in healthy women and patients paralleled each other with the most pronounced inflammatory response displayed by SAA. We conclude that SAA is a sensitive and reliable indicator of inflammatory events both in the pregnant and non-pregnant state.

Amyloid↗
PubMed1985

Smoking, alcohol, coffee, and familial factors: any associations with peptic ulcer disease? A clinically and radiologically prospective study.

In the period between 1980 and 1983 smoking habits, alcohol consumption, coffee drinking, and familial occurrences of peptic ulcers were studied in patients with gastric or duodenal ulcer in North Norway. The results were compared with those in two control groups matched for sex and age but without anamnestically known previous peptic ulcer disease. Statistically significant increased familial occurrences of peptic ulcer were found in relatives of patients both with gastric and with duodenal ulcer, compared with the control group. Furthermore, significantly more smokers were found in the two groups of patients than in the control groups. Patients with duodenal ulcers smoked more than those with gastric ulcer. Both the consumption of coffee and that of alcohol, however, were significantly reduced in the ulcer patients compared with their controls. Therefore, both familial factors and smoking habits appear to have some relationship or even play etiologic roles in the development of peptic ulcer disease, at least in the northern part of Norway. Coffee drinking and intake of alcohol seem to be of no importance. Both tobacco smoking and familial accumulation of peptic ulcers increased the relative risks of getting both gastric and duodenal ulcer as compared with 'non-exposed' persons. Furthermore, a positive correlation was found in men between the quantity of smoking and the risk of developing duodenal ulcer.

Adolescent↗
PubMed1985

A clinical comparison between males and females with ankylosing spondylitis.

Forty-four females and 82 male patients with ankylosing spondylitis (AS) were compared in a retrospective study. No differences were found with respect to age at onset of disease, initial symptoms, work performance or peripheral joint involvement. Furthermore, males and females did not differ in restriction of spinal mobility, chest expansion, frequency of acute anterior uveitis or mean concentration of IgA. Males had significantly higher frequency of elevated C-reactive protein whereas mean erythrocyte sedimentation rate showed no such difference.

Adult↗
PubMed1984

Pregnancy and rheumatic disease. A review of recent studies in rheumatoid arthritis and ankylosing spondylitis.

The present paper reviews the results of recent investigations into the influence of pregnancy and sex hormones on rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Prospective patient studies have shown that pregnancy exerts a beneficial effect on the majority of RA patients, while AS patients generally have unchanged disease activity during gestation. In AS, gestational remission was confined to patients with accompanying diseases. A postpartum disease flare-up occurred commonly in both RA and AS. Blood parameters reflected mainly the biochemical changes of normal pregnancy. A decrease of circulating immune complexes has been found in RA patients remitting during pregnancy. No single serum factor or combination of serum factors responsible for gestational remission could be detected. The possible influence of alpha 2-pregnancy-associated globulin on disease activity in pregnant patients remains contradictory. Hormonal contraceptives have been found to be protective against the manifestation of RA in four of five studies. However, no beneficial effect of sex hormones on the symptoms of established RA and AS could be demonstrated.

Arthritis, Rheumatoid↗
PubMed1984

The influence of pregnancy on blood parameters in patients with rheumatic disease.

To evaluate the mutual effect of pregnancy and rheumatic disease, 17 laboratory parameters have been monitored in 10 patients with rheumatoid arthritis (RA) and 13 patients with ankylosing spondylitis (AS), studied prospectively during and after gestation. Thirty-one healthy pregnant women served as controls. In the two patient groups, laboratory measurements during gestation, including several acute phase proteins, paralleled those found in healthy controls, indicating that rheumatic disease has no adverse effect on pregnancy. When the non-pregnant period was evaluated, elevated levels of IgG and IgM in RA and elevated ESR and IgA appeared to be predictive indices of the gestational remissions of RA and AS. Thus, a specific immunologic reactivity may be the main condition for remission during pregnancy.

Adolescent↗
PubMed1983

Piroxicam in human breast milk.

In 2 nursing women, piroxicam was present in breast milk at about 1% of the concentration in maternal serum. None was detected in serum from the baby fed by one of them.

Adult↗
PubMed1983

HLA-B27-negative arthritis related to Campylobacter jejuni enteritis in three children and two adults.

Five out of 37 patients with proven Campylobacter jejuni enteritis developed arthritis. Two adult patients presented with classical Reiter's syndrome. One of the three children had reactive arthritis, and clinical suspicion of septic arthritis could not be confirmed in two. The acute synovitis subsided usually without treatment in all patients within 3-7 days, while arthralgia persisted longer in 4 patients. HLA-B27 was not present in the 5 patients with arthritis, but was found in 4 others. In Northern Norway, Campylobacter fetus ssp. jejuni is more frequently isolated from stool specimens than Salmonella, Shigella and Yersinia enterocolitica. Synovial fluid should be cultured following Campylobacter jejuni enteritis in arthritis patients.

Adolescent↗
PubMed1983

Comparison between serum alpha 2-pregnancy-associated globulin and activity of rheumatoid arthritis and ankylosing spondylitis during pregnancy.

A possible association between alpha 2-pregnancy-associated globulin (alpha 2-PAG) and activity of rheumatoid arthritis (RA) during pregnancy was investigated. In a prospective study, the correlation between disease activity and serum alpha 2-PAG levels during and after pregnancy was evaluated in 11 women with RA. For comparison, 12 women with ankylosing spondylitis (AS) and 14 healthy women were also studied. No correlation between improvement of disease activity and serum alpha 2-PAG levels could be detected in pregnant RA or AS patients. In contrast, a positive association between total disease activity score and serum alpha 2-PAG levels was found in pregnant RA and AS patients.

Adolescent↗