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Biomedical subjects

M Ortega Calvo

Publications and source records attributed to M Ortega Calvo.

At least 19 recordsLinked to original sources

[Upon scientific accuracy scheme at clinical specialties].

Will be medical specialties like sciences in the future? Yes, progressively they will. Accuracy in clinical specialties will be dissimilar in the future because formal-logic mathematics, quantum physics advances and relativity theory utilities. Evidence based medicine is now helping to clinical specialties on scientific accuracy by the way of decision theory.

Clinical Medicine↗

[Hematogenous sternal osteomyelitis and community acquired pneumonia in a methicillin-susceptible Staphilococcus aureus sepsis].

We report here a case of primary haematogenous osteomyelitis diagnosed in a young mild asthmatic male with immunocompetence. A hard job worked as trigger of the septic picture from a forunculosis lesion located on the abdominal wall. Meticilin-susceptible Staphylococcus aureus was isolated from blood cultures and from sternal aspiration liquid. Two months after clinical onset Ig G 4 elevation was achieved at the immunodeficiency screening. Stafilococycal lung CT images accompanied to the septic course. Intravenous cloxacilin and gentamycin treatment followed by oral rifampicin and levofloxacin achieved a total recovery.

Adult↗

[CA 19.9 and HDL-cholesterol behaviour in a sporadic colorectal carcinoma sample].

BACKGROUND AND OBJECTIVE: We have carried out a comparative prediction analysis in sporadic colorectal carcinoma of plasmatic lipids and currently tumor markers used in this neoplasia (carcinoembrionary antigen - CEA, CA 19.9 and sialic acid -SA). PATIENTS AND METHODS: Transversal hospital-based case-control study. Sample was composed by 53 sporadic colorectal neoplasia patients just before surgery and 40 non matched controls. A 90 per cent of cases were at Dukes A and B stages. A multivariable model was fitted with non-conditional logistic regression. Confidence intervals were calculated at 95 per cent of confidence. Model sensibility and specificity were performed at 50 per cent cutting point. We also explored possible interactions. RESULTS: All three tumor markers (CEA, CA 19.9 and SA) were elevated in cases (p<0.01). Multivariable model included: Total cholesterol (TC) (OR= 0.69; CI: 0.50-0.96) high density lipoprotein fraction (HDL) (OR = 0.30; CI: 0.11-0.83) very low density lipoprotein fraction (VLDL) (OR = 2.21; CI = 1.07-4.55) years of age (OR = 1.11; CI = 0.98-1.26) CA 19.9 (OR = 1.20; CI = 1.02-1.42) and alkaline phosphatase (OR = 1.09; CI = 1.01 - 1.19). No interactions were found out. Model sensibility reached 96.23% and a specificity of 92.50%. CONCLUSIONS: HDL showed a similar diagnostic strength than CA 19.9 in this sporadic colorectal carcinoma sample but with an inverse OR. This multivariable model is going to be validated.

Biomarkers, Tumor↗

[Kluyvera cryocrescens: a positive urine culture in a young girl with persistent proteinuria].

Kluyvera genus usually shows two kinds of species: K. ascorbata and K. cryocrescens, DNA hybridization let us to differentiate a third group: Kluyvera species 3. Its diagnosis is quite uncommon and its taxonomy have been recently clarified. We report here a ten years female record with a chronic proteinuria and a positive urine-culture for K. cryocrescens. Axetil cefuroxime treatment was absolutely succesful. Kluyvera infections are difficult on the whole to joint with some specific clinical features.

Bacteriuria↗

[Congenital deficiency of protein C with late clinical manifestation].

The congenital deficit of protein C has a great diversity of clinical manifestations regarding age. In this paper, we describe the case of a man whose initial symptomatology appeared at the age of 68. Protein C is a vitamin-K dependent plasmatic glycoprotein which has anticoagulant activity through the inactivation of factors Va and VIIIa. The hereditary deficit of protein C is usually presented in a dominant autosomic mode with partial penetration and its prevalence is estimated in each of 200-300 healthy blood donors.

Aged↗