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Biomedical subjects

M Orosz

Publications and source records attributed to M Orosz.

At least 37 records · Page 2Linked to original sources
PubMed1985

Effect of Zaditen on serum neutrophil chemotactic activity in exercise-induced asthma.

Zaditen has a partial blocking effect in exercise-induced asthma, but the mechanism of this effect is unknown. In our study we investigated the effect of Zaditen on one of the mediators released by mast cells. We measured the serum neutrophil chemotactic activity - by using a modified Boyden chamber assay - after 2 week's treatment with Zaditen or placebo. The airway parameters (SGaw) were recorded with a wholebody plethysmograph. Our studies on 10 patients show that Zaditen has a protective effect on the release of the neutrophil chemotactic factor during an exercise challenge test. A direct effect of Zaditen on the mast cell degranulation process is postulated.

Adult↗
PubMed1983

Alteration in the reactivity of hamster cheek pouch arterioles to prostaglandin E2 and noradrenaline during pregnancy or sex steroid treatment.

Dioestrous and pregnant, or ovariectomized hamsters treated with sunflower oil, oestradiol or progesterone were anesthetized with pentobarbital and the arterioles of the cheek pouch membrane were prepared for microcirculatory study. Prostaglandin E2 (PGE2) or noradrenaline (NA) were topically applied and changes of the arteriolar diameter were measured on the screen of a closed-circuit television. PGE2 induced arteriolar dilatation in dioestrous or ovariectomized hamsters, but induced vasoconstriction in pregnant or in oestrogen-treated animals. Vasoconstriction induced by PGE2 in oestrogen-treated animals disappeared after administration of alpha-adrenergic blockers. In this situation, PGE2 induced vasodilatation once again. NA elicited arteriolar constriction in each experimental group. In ovariectomized hamsters treated with oestrogen the constriction was more pronounced than in progesterone treated animals. In pregnant animals it was significantly greater on day 14 than in dioestrous animals. Progesterone treatment blunted the vascular effect of both PGE2 and NA. It was concluded that the reverse effect of PGE2 and the increased sensitivity to NA induced by high oestradiol levels may have roles in the regulation of local blood flow during the ovarian cycle and pregnancy.

Animals↗
PubMed1982

Enhancement of the sensitivity of hamster check pouch arterioles to beta-adrenergic stimulus during pregnancy.

The adrenergic beta stimulant fenoterol induced a dose-dependent vasodilatation of hamster cheek pouch arterioles. The response to fenoterol was significantly larger on day 14 of pregnancy than in metoestrous animals. Since the serum progesterone and 17 beta-oestradiol level were also elevated on day 14, a relationship was suggested between the enhancement of vascular sensitivity and sex-steroid hormone levels.

Animals↗