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Biomedical subjects

M Okada

Publications and source records attributed to M Okada.

At least 1,315 records · Page 73Linked to original sources

ENG findings in patients with Bell's palsy. Relationship between visual suppression and clinical course.

Electronystagmography (ENG) is known to be a useful method for the evaluation of vestibular disorders. We tested 40 Bell's palsy patients who visited our clinic within 3 weeks after the onset of paralysis with ENG. Regarding the ENG findings and facial nerve damage, there were no correlations between the severity of paralysis in the initial period and the degree of paralysis recovery and existence of spontaneous, positional and positioning nystagmus. Patients with CP had a significantly severe paralysis in the initial period, but then showed varying degrees of recovery from the paralysis. Appearance of DP was not dependent upon the severity of facial paralysis in the initial period or the degree of paralysis recovery. Patients without visual suppression had a more severe paralysis in the initial period and a poor paralysis recovery at 3 months after the onset of paralysis.

Adolescent↗

Relationship between an activated N-ras oncogene and chromosomal abnormality during leukemic progression from myelodysplastic syndrome.

The relationship between chromosomal abnormality and oncogene activation was investigated during leukemic progression in two patients with myelodysplastic syndrome (MDS). Both patients had partial or complete deletion of chromosome 5 in metaphase cells obtained throughout the progression to leukemia. Analysis with specific oligonucleotide probes revealed that bone marrow cells containing an activated N-ras oncogene proliferated in a dominant manner during the process of leukemic conversion in both patients. These observations suggest that the chromosomal abnormality may precede activation of the N-ras gene in these patients, and that both the chromosomal abnormality and the activated N-ras oncogene contribute to the development of leukemia.

Acute Disease↗