[Glyceraldehyde-3-phosphate dehydrogenase of liver (author's transl)].
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Biomedical subjects
Publications and source records attributed to M Oguchi.
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The following are the clinical results of amoxicillin used for 21 cases of purulent dermatoses. Amoxicillin was remarkably effective in 5 of total 21 cases, effective in 12, slightly effective in 2 and non-effective in 2; that is, amoxicillin produced good results. One case each of drug eruption and abdominal distention were observed as side effects. Judging from its level in the blood, amoxicillin is expected to exhibit good therapeutical effect at a daily dose of 750 approximately 1,000 mg. Amoxicillin can be considered to be an effective drug for purulent dermatoses without severe side effect.
D-Glucosamine was found to be phosphorylated by a rat liver extract in the presence of a high concentration of glucose, which was formerly believed to be a strong competitive inhibitor of this reaction. Results suggested that glucosamine may be phosphorylated by high Km hexokinase, i.e. glucokinase [EC 2.7.1.2]. The enzyme involved was separated from specific N-acetyl-D-glucosamine kinase [EC 2.7.1.59]. The phosphorylation was not inhibited by a physiological level of glucose or glucose 6-phosphate, which strongly inhibited low Km hexokinase. The apparent Km of glucokinase for glucosamine was estimated as 8 mM, which is ten times that of low Km hexokinase.
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