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Biomedical subjects

M Ogiso

Publications and source records attributed to M Ogiso.

At least 73 records · Page 4Linked to original sources
PubMed1986

Effect of alpha-methyldopa administration during pregnancy on the development of a child's sleep.

A male infant was born to a mother who had been suffering from primary hyperaldosteronism with the administration of alpha-methyldopa (MD) during pregnancy. His behavioral development, especially that of sleep, was studied by means of sleep-awake rhythm and polysomnography recordings (PSG) from 2 months to 2 years and 5 months of age. His daily sleep-awake rhythm showed some abnormal pattern. As to the PSG, the proportion of each sleep stage was normal and the two types of body movements (BM) showed various patterns. A paradoxical increase was seen in the twitch movement of some muscles. MD affects the catecholamine system in the CNS and human sleep. Since the sleep-awake rhythm and BM are thought to be related to the monoaminergic system in the CNS, we assume that his behavior and sleep disorders are the effects of the maternal MD administration during pregnancy.

Brain↗
PubMed1986

Polygraphical study on age dependent epileptic encephalopathy--relationship between body movements during sleep and prognosis.

Body movements (BMs) during sleep in patients with age dependent epileptic encephalopathy (ADEE) were studied polysomnographically in order to clarify the underlying mechanism of intractability and the age dependent trend. Twenty patients were divided into two groups according to the prognosis of convulsions. In the good prognosis group, BMs were nearly normal except for a low frequency in some cases. In the intractable group with seizures which were uncontrollable by medication and recurred within a year, BMs showed abnormalities as follows: abnormal distribution according to sleep stages, and/or a low frequency; increased BMs on therapy with prednisolone or ACTH. Moreover, a paradoxical increase of BMs with age and recurrence of seizures concomitantly occurred in the course of the disease. Status epilepticus appeared in cases under 1-DOPA administration or with a strikingly high frequency of BMs. Since electrophysiological evidence indicates that BMs during sleep are modulated by the dopaminergic (DA) system, the present data might suggest that prognosis of convulsions in ADEE depend upon, at least in part, the DA system. And denervated supersensitivity of that system might give rise to recurrence of seizures and status epilepticus.

Adolescent↗
PubMed1985

Identification of estradiol in the ovaries of the silkworm, Bombyx mori.

Estradiol was extracted and partially purified from the ovaries of the silkworm, Bombyx mori. Identification of estradiol was done by use of radioimmunoassay (RIA) and by gas chromatography-mass spectrometry (GC-MS) after derivatization into the ethyldimethylsilyl derivative. Concentration of estradiol in the ovaries was estimated to be 176 pg/g (RIA) and 63 pg/g (GC-MS).

Animals↗
PubMed1984

Trehalases from the male accessory glands of the American Cockroach: developmental changes and the hormonal regulation of the enzymes.

Two types of trehalases, designated CM-I and CM-II, were detected in the male accessory gland of the American cockroach and they could be separated by CM-cellulose chromatography (S. Y. Takahashi, S. Higashi, S. Minoshima, M. Ogiso, and K. Hanaoka, 1980, Int. J. Invert. Reprod. 2, 373-381). Trehalase activity in the gland showed a rapid increase after adult emergence. The relative activities of the two enzymes were followed separately during adult development. The appearance of CM-II preceded that of CM-I during adult development. Allatectomy and decapitation of newly molted adults resulted in inhibition of the increase of enzyme activity, and in the allatectomized cockroach, CM-II, which is the major enzyme activity in the gland, was missing. Implantation of the corpora allata as well as application of JH-III and the JH analogs isopropyl-11-methoxy-3,7,11-trimethyl-2,4,-dodecadienoate (ZR-515) and 6,7-epoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene (R-20458) into the decapitated animals restored the enzyme activities. The data suggested that trehalase in the male accessory gland was under the control of the corpora allata. The regulation of trehalase activity in the male accessory gland was discussed with respect to its function.

Animals↗
PubMed1984

Uptake and metabolism of [3H]ecdysone in cultured ovaries of the silkworm, Bombyx mori.

Uptake of ecdysone by ovaries of the silkworm, Bombyx mori, was studied by organ culture. [3H]Ecdysone was transported almost linearly into the ovary for up to 3 h of the incubation. The uptake was proportional to the concentration of the labeled ecdysone, unsaturably, at concentrations ranging up to 10(-6) M. Ecdysone which had been transported into the ovary could usually be removed when the ovary was re-transferred to the ecdysone-free medium. Analysis of the transported compounds by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) revealed the marked conversion of ecdysone into 20-hydroxyecdysone, unknown metabolites and conjugated forms. Physiological significance of the metabolic activity of the ovary is discussed with respect to the accumulation of ecdysteroids in the ovary.

Animals↗
PubMed1984

[Body movements during sleep in Lennox syndrome].

In Lennox syndrome the brainstem which plays important roles in regulating sleep and its parameters is thought to be disturbed. In order to clarify the importance of the dysfunction of the brainstem in Lennox syndrome, polygraphic examination were studied and their findings were assessed with prognosis. 8 patients aged from 6 to 17 years were subjected to this study. They were divided into two groups according to their prognosis. Group 1 showed good prognosis. Seizures were easily controllable and have not occurred for more than 24 months. In group 2 seizures were intractable and were uncontrollable by medication. In 4 normal children ranging in age from 4 to 10 years, the same studies were performed. Recordings were performed on two consecutive nights and the second night recordings were used for analysis. Polygraph consisted of EEG from C4 and P4, bipolar EOG from electrode attached to outer canthus, surface EMG from submental muscle and 5 or 6 other muscles including trunk and limbs. Sleep stages were determined in each minute according to the standard of APSS. Body movements were classified into two types on the basis of their distribution over body parts and on duration of movements. Gross movements (GM) involved the body trunk and lasted for more than two seconds. Twitch movements (TM) were localized in one muscle on surface EMG recordings lasting less than 0.5 seconds. In normal children, the rate of GM in sleep stage 1 and REM are significantly higher than slow wave sleep. And this is the same in TM of all muscles.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

[Effect of radiotherapy against advanced carcinoma of the rectum].

In treating advanced carcinoma of the rectum, we have actively used radiotherapy as an adjunct to surgery to enlarge the group of patients indicating surgery and improve the remote results. Of total 423 patients with rectal cancer treated by us in the past 16 years, 202 patients (47.8%) received radiotherapy. Preoperative radiotherapy was performed on 90 of these patients, postoperative radiotherapy on 73 patients, preoperative plus postoperative radiotherapy on 15 patients, and radiotherapy alone on 24 patients. The present study is mainly concerned with preoperative radiotherapy. The purpose of preoperative radiotherapy is to increase the number of patients suitable for surgery. We selected Dukes-C cases without distant metastasis as indications for preoperative radiotherapy, and treated them by 2-step irradiation with 3,000-6,000 rads using Linac after 2 weeks of preoperative observation. The gross and histologic evaluation of the results of irradiation permitted us to conclude that over 3,000 rads was necessary for preoperative radiotherapy. Comparison of the results between preoperative radiotherapy and control groups showed that local recurrence occurred in 6.7% of the radiotherapy group and 9.0% of the control, and 5-year-survival rate was 62.7% and 53.2% respectively, with prognosis improved in the radiotherapy group.

Combined Modality Therapy↗
PubMed1979

Biocompatibility of apatite ceramics in mandibles.

Apatite ceramics composed of synthetic hydroxyapatite, Ca10(PO4)6(OH)2 were implanted in mandibles of adults dogs. The histological observations indicated that the apatite ceramic was closely contacted with newly formed bone tissue without any rejection phenomenon up to 2 weeks. An electron micrograph of non-decalcified ultra-thin section at 8 weeks showed that the apatite ceramic was directly bonded to newly formed bone and the mineralized bone tissue was grown into the micro pores of the ceramics independent on the pore size. It seemed that the outer surface of the apatite was exchanged by bone tissue. From these results it was considered that the apatite ceramic was a successful implant material in dental and surgical fields.

Animals↗
PubMedDate not supplied

Lesions of bone and bone marrow in myeloid leukosis occurring naturally in adult broiler breeders.

Lesions of bone and bone marrow in myeloid leukosis (ML) occurring naturally in adult broiler breeders were investigated pathologically. During gross examination, nodules and protrusions were commonly observed on the surface of the sternum, ribs, vertebrae, and synsacrum. The bone marrow of all the bones of the body was pale in color. Histologically, granulated myelocytes proliferated in the bone marrow of various bones and in the periosteum of the sternum, ribs, vertebrae, and synsacrum. The first proliferation of tumor cells occurred in the bone marrow of epiphysis. The myelocytes invaded through haversian and Volkmann's canals from the bone marrow to periosteal areas. Hematopoiesis was suppressed by marked proliferation of tumor cells in the bone marrow of the whole bone. Atrophy was also seen in the bones, including medullary bones of the chickens suffering from ML. Proliferation of myelocytes was seen in the bone marrow and periosteum of ossified cartilaginous rings of the trachea and larynx. Marked proliferation of myelocytes was seen in the dura mater of spinal cords, and it subsequently depressed the spinal cords. Bone formation with cartilage was seen in the periosteum of the sternum having marked proliferation of myelocytes in the bone marrow and periosteum. Ultrastructurally, tumor cells showed large nuclei and cytoplasm with large round electron-dense lysosomes. The virus particles were rarely detected in the cytoplasm of tumor cells. The polymerase chain reaction test of tumor samples showed positive for subgroup J avian leukosis virus. This study indicates that the myelocytes can invade through the compact bones to the periosteum in the sternum, ribs, vertebrae, synsarcum, and ossified cartilage of trachea and larynx having thinner compact bones. In addition, the periosteal osteogenesis with cartilage in the sternum may be reactive change against the bone atrophy because of the marked proliferation of myelocytes.

Animals↗