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Biomedical subjects

M Oda

Publications and source records attributed to M Oda.

715 records · Page 40Linked to original sources
PubMedDate not supplied

Plasma VEGF concentration can predict the tumor angiogenic capacity in non-small cell lung cancer.

We assessed the clinical utility of circulating angiogenic factors as a predictor for tumor angiogenesis in primary lung cancer. Circulating vascular endothelial growth factor (VEGF) and intratumoral VEGF were assessed by enzyme-linked immuno-sorbent assay (ELISA). There was a significant increase in the mean value of both plasma and serum VEGF concentration in primary lung cancer patients (n=97) compared to those of healthy controls (n=59). There was a significant correlation between plasma VEGF levels and microvessel density (MVD), and also between plasma VEGF and intratumoral VEGF levels. Plasma VEGF in patients with lung cancer appears to be a useful indicator of tumor angiogenesis.

Adult↗
PubMedDate not supplied

Tumor size and extension of lymph node metastases in N2 lung cancer.

In all patients with NSCLC, systematic nodal dissection was performed. Since 1981, 218 stage IIIA-N2 cases were resected. We registered 2 operative mortalities. Overall survival was 23% while, in completely resected cases, survival amounted to 30%. For long-term survival, favourable prognostic factors were cN2 T1-2 N2M0, single mediastinal node involvement and a tumor 20 mm or less in maximum size. The 5 yr survival rates of stage IIIA N2 patients was, respectively 48.1% with tumor diameter < 20 mm, 27.7% with diameter between 21-30 mm, 31.2% with diameter between 31-50 mm and, finally, 16.7% with tumors larger than 51 mm. When micrometastases to lymph nodes in p-stage I (stained with H-E) were examined with immunohistochemical staining, 27% (36 patients of 132) showed micrometastases.

Carcinoma, Non-Small-Cell Lung↗
PubMedDate not supplied

Morphometric study of nucleus ambiguus in multiple system atrophy presenting with vocal cord abductor paralysis.

AIM: To identify lesions responsible for vocal cord abductor paralysis (VCAP) in multiple system atrophy (MSA), we performed a morphometric study of the nucleus ambiguus which innervates the intrinsic laryngeal muscles. METHODS: Two autopsied cases of MSA presenting with VCAP and one control were examined. Both cases of MSA showed selective neurogenic atrophy of the posterior cricoarytenoid muscles among the intrinsic laryngeal muscles, while no abnormalities were seen in the control. From a block of the medulla oblongata, sections 10 microm thickness were cut serially without spacing and stained with cresyl violet. The ambiguus neurons were counted in all the sections to make a histogram. RESULTS: In the control case, ambiguus neurons showed densely populated areas and sparsely populated areas alternately with significant difference in the mean neuronal density between two areas. In MSA, ambiguus neurons were significantly decreased in number at all levels. It indicates that the neurogenic atrophy of the posterior cricoarytenoid muscle is derived from the neuronal loss of the nucleus ambiguus. CONCLUSION: Though it has still been controversial whether or not the ambiguus neurons are decreased in number in MSA with VCAP, we speculated possible reasons for the disagreement on the involvement of the nucleus ambiguus as follows: different mechanism of VCAP are playing role, and histometric data have been disturbed by factors such as split-cell counting error and marked variation in the distribution of the ambiguus neurons.

Adult↗
PubMedDate not supplied

[Porcelain veneers].

Through a clinical situation is shown the technique for the placement of a porcelain bonded veneer. Its significance with in the Esthetic Restorative Dentistry, advantages and disadvantages are emphasised. Together with the clinical procethe laboratorial steps are also shown. It was concluded that the bonded porcelain veneers are new options for a Restorative Dentistry more conservative with excellent esthetic results.

Acid Etching, Dental↗
PubMedDate not supplied

[Dimensional changes in die stones with an additive and sodium chloride].

The obtention of a working model and the preparation of the die must be developed with great care and attention to detail. Based on these principles, a study was conducted referring to the different kinds of special plasters or die plasters available on the market, with respect to dimensional alterations, as well as an investigation of the dimensional behavior of special plasters in the presence of two additives. The results shows that Vel-mix had the greatest difference. All the special plasters brands showed alterations when the Gypsum Hardener were used. These alterations did not occur with sodium chloride.

Calcium Sulfate↗
PubMedDate not supplied

Type III Machado-Joseph disease in a Japanese family: a clinicopathological study with special reference to the peripheral nervous system.

The clinical and pathological findings in a 58-year-old Japanese man suffering from type III Machado-Joseph disease are reported. The patient became affected at the age of 50 years and presented cerebellar ataxia, progressive external ophthalmoplegia and muscular atrophy, although extrapyramidal signs were never detected throughout the whole course of his disease. His mother, sister and son presented progressive ataxia in the third or fourth decade. The mode of inheritance is considered to be autosomal dominant. Pathological examination revealed severe involvement of the dentato-rubral, ponto-cerebellar and subthalamopallidal systems, spinocerebellar tracts and Clarke's column, cranial motor nuclei including the oculomotor systems and anterior horn cells. The involvement of the substantia nigra was relatively mild, and the nerve cells in the inferior olivary nucleus were well preserved. The distal portion of peripheral nerves was severely damaged. Although the striking feature of Machado-Joseph disease is a considerable variability in the individual clinical expression, there have not been many autopsied cases of this disease and efforts to clarify the clinico-pathological correlation in each phenotype have scarcely been made. Relatively mild changes in the substantia nigra and severe involvement of the peripheral nervous system, as in our case, may be the pathological hallmarks of the type III disorder.

Adult↗
PubMedDate not supplied

Recent advances in organ microcirculation research.

This review article dealt with progress in the research of gastroenterological organ microcirculation in Japan. It must be emphasized that this remarkable progress particularly in intravital microcirculatory observations at organ level is attributable to great improvement of microscopic devices combined with computerized system, development of new techniques for measuring microcirculatory blood flow and pioneering of a variety of fluorescent and isotope-labelled tracers. Little attention has been directed toward the fact that microvascular manifestations are perhaps the earliest signs of "cells and tissues" dysfunction in disease processes. The microvasculature undergoes a substantial remodeling not only in vascular wall structures, but also in network characteristics themselves especially in chronic disease. Those microvascular alterations in an organ system, which primarily originate in adaptations to the microenvironmental changes, would lead to the chronicity and self-perpetuation of disease. As has been noted in the IVth World Congress for Microcirculation organized by the Japanese Society for Microcirculation, which was held in Tokyo, July 26-30, 1987, further progress has been made in the research of organ microcirculation in the gastroenterological and other fields. It is the cornerstone for better understanding of the pathogenesis of organ diseases to clarify the earliest alterations in the microvasculature of an organ system from a combined aspect of microhemo- and microlymphocirculation using the newly developed techniques for microcirculation study.

Digestive System↗
PubMedDate not supplied

Thalamus degeneration in Japan. A review from clinical and pathological viewpoints.

12 Japanese cases with marked thalamus degeneration are reviewed. They are divided into 3 groups. The 4 cases of the first group showed a relatively short clinical course. Neuropathologically, the lesions of this group are selectively severe in the thalamus, and olivocerebellar atrophy is also observed. Because of the significance of the thalamic changes, this group is called 'primary thalamus degeneration'. The cases of combined system degeneration and presenile dementia, such as Pick's disease, are described in the 2nd and 3rd groups. In the thalamus, the developmentally younger, and medially and dorsolaterally located nuclei are most severely affected in all the cases. The substantia nigra, globus pallidus and cerebellar afferent systems, and occasionally the dentate nucleus, subthalamic nucleus and reticular formation, are also involved. In the cases of presenile dementia, in which the frontal and posterior parietal lobes are damaged, degenerated areas in the cerebrum and thalamus have a close relationship with each other genetically as well as in fiber connections. The clinicopathological relationship is discussed on the basis of those neuropathological findings.

Adolescent↗
PubMedDate not supplied

Motor neuron disease with involvement of the pallido-luysio-nigral system and mesencephalic tegmentum.

A rare case of motor neuron disease and involvement of the pallido-luysio-nigral system and brainstem tegmentum is presented. A 51-year-old man developed progressive muscle atrophy with fasciculation predominantly in the shoulder girdle, upper arms, upper back, and neck in addition to hyperreflexia and a positive Chaddock reflex. He also had retinitis pigmentosa, high arched palate, and mild hand tremor. He eventually developed bulbar palsy and died of paralysis of the respiratory muscles 11 years after the onset of his illness. Neuropathological examinations showed prominent neuronal loss and gliosis in the pallido-luysio-nigral system and the tegmentum of the brainstem in addition to the simultaneous involvement of the upper and lower motor neurons. This patient and 6 similar patients are discussed in relation to pallido-luysio-nigral atrophy and the topographic distribution of degeneration in amyotrophic lateral sclerosis.

Amyotrophic Lateral Sclerosis↗
PubMedDate not supplied

Evaluation of the clamshell incision for bilateral pulmonary metastases.

To treat bilateral pulmonary metastases during a single operation, simultaneous bilateral thoracotomy via median sternotomy is usually employed. With this approach, however, it is sometimes difficult to access lesions located on the dorsal side of the left lower lobe. We have explored the use of clamshell incisions for such difficult cases. From 1990 to 1995, we studied the use of clamshell incisions in 14 patients with bilateral pulmonary metastases. The average duration of surgery was 212 minutes, the average volume of intraoperative blood loss was 477 ml, and the average number of metastatic lesions extirpated was 23. The endotracheal tube could be removed immediately after the operation in 12 patients, while the remaining 2 patients, who underwent an extensive operation, needed 3 and 4 days of intubation. The arterial blood gas analysis on the first postoperative day for the former 12 patients was as follows: the average value of PaCO2 was 44.4 mmHg, and the average value of PaO2 was 140.4 mmHg (FiO2 = 0.4). None of the patients experienced severe pain or respiratory distress that impaired their daily activities due to continuous epidural anesthesia following surgery. The length of time from surgery to discharge was relatively short, averaging 22 days. We have not encountered any sternal override in our patients. Although we cannot ignore the biological behaviour of primary tumors when selecting a surgical approach, the clamshell incision seems to provide a useful means of thoracotomy when treating bilateral pulmonary metastases. We intend to use this approach in future, taking into careful consideration the indication of each individual case.

Adolescent↗
PubMedDate not supplied

Clinicopathologic study of mucoepidermoid carcinoma of the lung.

BACKGROUND: Mucoepidermoid carcinoma is a relatively uncommon form of lung cancer and has generally been viewed as a low grade malignant tumor. The present study was undertaken to establish a clinicopathological characterization of patients with this cancer who were treated surgically at Kanazawa University Hospital. METHODS: Between 1973 and 1975, 10 patients with mucoepidermoid carcinoma were surgically treated in our department. RESULTS: The 10-year survival rate after surgery for the central type of carcinoma was 67%, while the 4-year survival rate for the peripheral type was 25%. When the survival rates were analyzed in terms of Conlan's grades, grade 1 cases had a 10-year survival rate of 80%, while the 4-year survival rate for grade 2 and 3 cases was 20%. The four patients who survived 5 years or more following surgery all had a grade 1 central type tumor. CONCLUSIONS: These results suggest that mucoepidermoid carcinoma of the lung should not be viewed uniformly as a low grade malignant tumor, but that this tumor can sometimes be highly malignant with a poor prognosis. Since this tumor is often difficult to distinguish from adenosquamous carcinoma, and because accurate distinction between these two types of tumor seems to be essential for establishing a prognosis, there is an urgent need for a valid pathological method for differential diagnosis of mucoepidermoid carcinoma.

Adult↗
PubMedDate not supplied

Novel therapeutic approach to primary biliary cirrhosis patients: anti-eosinophil strategy.

BACKGROUND/AIMS: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown cause. Morphologically, PBC is characterized by eosinophil infiltration into the portal tract in recent studies. Pranlukast, a new drug, is a leukotriene antagonist, which suppresses eosinophil infiltration in atopic dermatitis or asthma. METHODOLOGY: In this study, pranlukast monotherapy was used to treat 12 patients with a diagnosis of PBC, classified as stage I or II according to Scheuer's classification on the basis of liver biopsy findings. RESULTS: An improvement in alkaline phosphatase (ALP) was observed beginning one month after the start of pranlukast therapy in all 12 patients. Improvement in ALP and gamma-GTP values was statistically observed at 1, 2, and 6 months after the start of treatment. IgG and IgM values improved in all 12 patients at 2 months and 6 months after the start of treatment. Absolute eosinophil counts improved at 6 months after the start of treatment. CONCLUSIONS: Given its efficacy and the absence of side effects, planlukast appears to be the medical treatment of choice for patients with early-stage PBC. But, a randomised, controlled, double-blind trial is urgently needed.

Alanine Transaminase↗