Problems with ensuring a double blind.
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Cyclohexanols↗
Biomedical subjects
M Oakley-Browne
Publications and source records attributed to M Oakley-Browne.
Anxiety disorder.
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Adrenergic beta-Antagonists↗
Total cholesterol and suicidality in depression.
There exists considerable controversy regarding an association between low total cholesterol and increased mortality from suicide. As suicide mortality is a crude marker for suicidal ideation and behavior, we investigated the association between total cholesterol and suicidality in a depressed sample. Ninety men and women meeting structured criteria for a major depressive episode of at least moderate severity participated in a study of predictors of treatment response. A three level variable codified the degree of suicidality in the previous month: no suicidal thoughts (39/90), suicidal ideation or plan (38/90), and a suicide attempt (13/90). There was a significant univariate association between lower cholesterol levels and increasing degrees of suicidality. In a multivariate analysis, this association was the only one that neared statistical significance (p = 0.068). Although it is premature to conclude that these variables are causally associated, data from a number of sources suggest that this association is worthy of further study.
Adult↗
Parental bonding in men with alcohol disorders: a relationship with conduct disorder.
Men from a clinical treatment setting suffering from alcohol dependence, and randomly selected men from the community diagnosed as having alcohol abuse and/or dependence, completed the Parental Bonding Instrument. The men from the alcohol treatment setting perceived both parents as having been uncaring and overprotective. In the general population sample, an uncaring and overprotective parental style was strongly associated with childhood conduct disorder, but not with alcohol disorder symptoms. This discrepancy in perceived parenting highlights the difficulties in extrapolating findings about aetiological factors for alcohol disorders from clinical samples. It also suggests that childhood conduct disorder and adult antisocial behaviour could influence which men with alcohol disorders receive inpatient treatment.
Adolescent↗
Mania associated with small cell carcinoma of the lung.
This paper describes a case of small cell carcinoma of the lung with ectopic adrenocorticotropic hormone (ACTH) production which presented with mania. The association between manic syndromes and the various forms of glucocorticoid or ACTH excess is discussed.
ACTH Syndrome, Ectopic↗