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Biomedical subjects

M O Tso

Publications and source records attributed to M O Tso.

At least 199 records · Page 11Linked to original sources
PubMed1975

Kayser-Fleischer ring and associated cataract in Wilson's disease.

A 22-year-old woman with hepatolenticular degeneration, or Wilson's disease, was note clinically to have Kayser-Fleischer rings and associated cataracts. Histopathologic, histochemical, and electron microscopic study of the cornea showed deposition of copper in the peripheral Descemet's membrane, with excessive accumulation in Hassall-Henel warts. Copper deposits were also noted in the anterior and posterior lens capsule without the presence of degenerative changes in the epithelial or cortical cells of the lens. We propose that cellular activity is required for the depostion of copper material into the thick basement membranes of the cornea and lens, in contrast to the concept of simple diffusion.

Adult↗
PubMed1975

Morphologic evidence of photoreceptor differentiation of pinealocytes in the neonatal rat.

The pineal body and the retina of the neonatal Sprague-Dawley rat were studied by light and electron microscopy, and the morphologic differentiation of the parenchymal cells of the pineal body was compared with that of the developing photoreceptor cells of the retina. Between the ages of 4 and 12 days after birth, some of the developing pinealocytes were observed to become elongated and polarized, with their nuclei located at one pole. "Synaptic" ribbons were observed within the cell body. At the opposite pole the cells developed elongated cell processes that initially contained microtubules and ribosomes. These cell processes projected into luminal spaces and were attached by structures resembling zonulae adherentes to the adjacent cells. Extending from the tips of the cell processes, cilia with a 9 + 0 arrangement were observed. Lamellated and vesicular membranes were noted at the tips of the cilia. Such morphologic differentiation, however, could be observed only in rats younger than 17 days. Comparison of the morphologic features of the neonatal pinealocytes with those of the developing retinal photoreceptor cells showed much similarity. It is suggested that the pinealocytes of the neonatal rat undergo "photoreceptor-like" differentiation during a transient neonatal period. Such morphologic differentiation may provide an explanation for light-induced biochemical changes described in neonatal rats whose eyes had been enucleated.

Animals↗
PubMedDate not supplied

Ex Errato Lux. Concept and development of the Verhoeff Society.

With a history of 39 years, Verhoeff Society is one of the oldest subspecialty groups in ophthalmology. The society was formed to establish a forum to discuss ophthalmic pathology. This paper details the original inception of the Society, its current activities and its influence in the development of ophthalmic pathology clubs in the U.S. and across the world.

History, 20th Century↗