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Biomedical subjects

M O Perry

Publications and source records attributed to M O Perry.

At least 55 records · Page 3Linked to original sources
PubMed1980

Carotid artery injuries caused by blunt trauma.

Carotid artery injuries caused by blunt trauma often cause thrombosis and delayed neurologic deficits, and are associated with mortality rates of up to 40%. In this series of 17 patients with blunt trauma of the carotid, three had no symptoms, ten patients had limb paresis and four had severe neuroligic deficits. The wounds were identified by arteriography; repair was attempted in 15 patients, and successful in eight. All eight patients with successful repair were improved or normal after surgery, but only two out of nine patients without repair improved, and four died. The mortality rate for the series was 23%, but only 14% in the patients who had carotid surgery. This experience suggests that repair is safe and effective in patients with carotid injuries in whom prograde flow continues and only mild neurologic deficits are present. In contrast, patients with complete occlusion, severe neurologic problems, and altered consciousness are not likely to be helped by attempts at revascularization.

Adolescent↗
PubMed1979

Remote bypass grafts for managing infected popliteal artery lesions.

Infected false aneurysms of the popliteal artery may complicate vascular repairs for trauma or primary arterial disease. Adequate debridement and drainage are necessary if the limb is to be salvaged, but direct arterial grafting through the infected area cannot be performed safely. Vascular reconstruction can be accomplished by performing a femoropopliteal or iliopopliteal bypass through a lateral approach, then the infected artery can be removed safely through separate incisions. This technique was used successfully in managing four patients with infected popliteal artery pseudoaneurysms.

Adult↗
PubMed1978

Muscle and subcutaneous oxygen tension. Measurements by mass spectrometry after sympathectomy.

Utilizing the mass spectrometer, tissue oxygen tension (TPO2) in the resting state was measured in the extremities of ten dogs before and after lumbar sympathectomy. Although there was considerable variation between individual dogs, significant changes in tissue oxygenation were not consistently obtained in the group as a whole, althouth femoral arterial blood flow increased in all animals. Using TPO2 changes to estimate perfusion, no significant increase in nutritive flow could be demonstrated.

Animals↗
PubMed1978

The validity of normal arteriography in penetrating trauma.

The detection of underlying arterial injury is a major problem in the management of penetrating trauma. Arteriovenous fistula and false aneurysm are late sequelae of unrepaired injuries. The diagnostic accuracy of arteriography in clinically occult injury has not been defined. One hundred and seventy-seven patients with 183 penetrating extremity wounds underwent arteriography followed by operative vessel exploration. Arteriogram/operation correlation demonstrated 36 true-positive, 132 true-negative, 14 false-positive, and one false-negative arteriogram. Arteriography is sufficiency sensitive to exclude the presence of arterial injury in patients with equivocal clinical signs of injury. The radiographic changes are often sublte and diagnostic accuracy demands attention to the details of technique and interpretation. Unequivocal clinical signs of arterial injury and any arteriographic abnormality are indications for operative exploration.

Angiography↗
PubMed1976

Kinetics of heparin administration.

Many clinicians prefer intravenous administration of heparin sodium because of unpredictable absorption from extravascular sites. In this experimental study, large doses of heparin labeled with sulfur 35 were injected into 34 dogs separated in groups according to dosage and route of administration. Anticoagulation and plasma heparin levels were assessed at half-hour intervals. Intravenous injection produced immediate anticoagulation followed by a predictable decline. Subcutaneous or intramuscular injection resulted in delayed onset and variable levels of anticoagulant activity. The wide range of response following intermittent injection suggests that continuous intravenous infusion offers a more reliable method of treatment.

Animals↗
PubMed1976

Detection and management of deep vein thrombosis.

The accuracy of diagnosis of deep venous thrombosis is significantly improved by combining clinical evaluation with other adjunctive methods, especially fibrinogen uptake tests, technetium scans, Doppler techniques and phlebography. Using these studies, early treatment with intravenous administration of heparin can be begun and in selected cases with long-term risks, warfarin is often useful. These same drugs, in different dosage schedules, may also be helpful as prophylaxis. With these methods of treatment, thrombectomy and caval interruption are required less often. If interruption of inferior vena cava flow becomes necessary, several new methods utilizing intracaval filters are proving to be very useful.

Diagnostic Errors↗