The fate and urinary metabolites of thiamine propyl disulfide in rats.
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Animals↗
Biomedical subjects
M Numata
Publications and source records attributed to M Numata.
The effect of portacaval shunt on hyperlipidemia in rats.
Hyperlipidemia was induced in rats by feeding them cheese mixed with high levels of cholesterol. Triglyceride levels more than doubled from 70.4 +/- 25.8 mg/dl before the diet to 160.1 +/- 50.5 mg/dl three weeks after initiation of the diet, and cholesterol levels were increased by approximately 25% from 72.5 +/- 8.1 mg/dl to 98.9 +/- 18.5 mg/dl after three weeks of the diet. The effects of microsurgically created side-to-side and end-to-side portacaval shunts were then studied. Triglyceride levels were lowered to normal after either type of shunt (68.4 +/- 19.2 mg/dl in the side-to-side group and 58.1 +/- 25.7 mg/dl in the end-to-side group) by four weeks after the creation of the shunt. Cholesterol levels tended to be slightly lower after either type of portacaval shunt, but did not return to normal. The mechanism by which the portacaval shunt reduced elevated triglyceride levels and, to a lesser extent, cholesterol levels is not clear, but hyperlipidemia induced by a high cholesterol diet in rats should be a useful model for further study of this question.
Animals↗
Platelet aggregation during menstrual cycle and pregnancy.
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Adenosine Diphosphate↗
Suppression of N(epsilon)-(carboxymethyl)lysine generation by the antioxidant N-acetylcysteine.
OBJECTIVE: Accumulated evidence suggests that N(epsilon)-(carboxymethyl)lysine (CML), which is a dominant antigen of advanced glycation end-products (AGEs), is generated in the peritoneal cavity of patients undergoing continuous ambulatory peritoneal dialysis (CAPD), and that this process may be involved in the pathophysiology of the peritoneal injury found with CAPD treatment. Since CML is a sequential product of glycation and oxidation processes, CML generation could be suppressed by antioxidants. The aim of this in vitro study was to clarify the effect of N-acetylcysteine (NAC), an antioxidant, on CML generation from proteins under high glucose settings mimicking peritoneal dialysis solutions. DESIGN: Test proteins (bovine serum albumin/type I collagen) were incubated continuously for 16 weeks in glucose solutions (200 mmol/L) with or without NAC (2 mmol/L), and the generation time courses (8 and 16 weeks) of CML and furosine (the biomarker of the glycation products of the early Maillard reaction) were determined. RESULTS: In both proteins, furosine and CML were progressively generated in accordance with the duration of the incubation period. No apparent differences were found between solutions with and without NAC in furosine levels at the 8th and 16th weeks. However, the generation of CML was lower in the solution with NAC throughout the test periods. CONCLUSION: The results showed that NAC could suppress the generation of CML. This indicates the therapeutic potential of antioxidants for the glycoxidative stress-related peritoneal injury occurring during CAPD.
Acetylcysteine↗
Caudal left hepatic duct in relation to the umbilical portion of the portal vein.
BACKGROUND/AIMS: Intrahepatic ducts from the left lateral segment of the liver are generally considered to run from the cranial to the umbilical portion of the left portal vein. This understanding often limits surgical exploration of the left hepatic ducts during both curative and palliative surgical procedures. The prevalence of ducts from the lateral segment running caudally to the umbilical portion was studied retrospectively on computed tomography (CT) films, and its clinical implications were evaluated. METHODOLOGY: One hundred and sixty-six DIC (drip infusion cholangiography) CT and 30 post-PTCD (percutaneous transhepatic cholangio-drainage) CT films taken during 4 consecutive years were reviewed giving special consideration to whether the ducts from the left lateral segment of the liver run caudal to the umbilical portion of the left portal vein. RESULTS: Corresponding variation was found in 3.6% of the DIC-CT examinations and in 3.3% of the CT examination after PTCD, respectively. CONCLUSIONS: The incidence of caudal left hepatic ducts with respect to the umbilical portion of the left portal vein was higher than expected from clinical experience. These results emphasize that more careful planning is necessary prior to hepatobiliary surgery.
Biliary Tract Surgical Procedures↗
Evaluation of non-invasive arteriography in the surgical treatment of abdominal aneurysms.
The accuracy of information on abdominal aneurysms for surgical procedure was evaluated and a comparison was made between aortography and combinations with transvenous aortography and non-invasive diagnostic methods such as radionuclide angiography, ultrasonography and computerized tomography in 33 clinical cases who were diagnosed as abdominal aneurysms by physical examination. Combined examinations provided reliable information on the extent of aneurysm, the relationship of renal and common iliac arteries, mural thrombi, patency of distal arteries and the relationship with surrounding organs, and were superior to that provided by aortography alone.
Adult↗