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Biomedical subjects

M Noda

Publications and source records attributed to M Noda.

At least 667 records · Page 37Linked to original sources

Enzymic hydrolysis of diol lipids by pancreatic lipase.

Chain length and positional specificities of pancreatic lipase for diol lipids have been examined by use of the synthetic substrates such as the diol esters and related esters that contain C6--C20 even-numbered saturated acids and oleic acid as fatty acids, and ethylene glycol, 1,2- and 1,3-propanediols, 1,3-, 1,4-, and 2,3-butanediols, monohydric alcohols, and glycerol as alcohols. No remarkable difference in the degree of hydrolysis was observed in the case of diol esters having C14--C20 fatty acids at least during 30-min digestion, though hydrolysis reached a maximum in diol diotanoates after the same period. Pancreatic lipase specifically released only the fatty acids esterified with the primary hydroxyl groups of diols.

Animals↗

Median rhomboid glossitis associated with amyloid deposition.

There are some controversies over the pathogenesis and clinical features of median rhomboid glossitis. A case of median rhomboid glossitis associated with amyloid deposition was presented. Clinically there was no organ involved in amyloid other than the tongue. It was suspected that median rhomboid glossitis occurred first and that amyloid was induced later.

Amyloid↗

Distribution and metabolism of polyacetylenes in safflower.

Safflower seedlings, tissues and subcellular fractions were used to investigate the distribution and biosynthesis of polyacetylenes. The polyacetylenes rapidly increased during germination, but were not detected in mature seeds. The polyacetylenes in the seedlings accumulated mainly in cotyledons rather than in hypocotyls and roots. Polyacetylenic hydrocarbons were distributed in the microsomes obtained from leaves and roots of the mature plants, while polyacetylenic epoxide was found in chloroplasts. A 1000 X g pellet from the immature seeds showed the highest activity for the incorporation of labeled acetate into the hydrocarbons. The epoxide was synthesized by chloroplasts from the cotyledons. These results, together with the data of polyacetylene distribution and tissue culture, suggest that chloropoasts may be essential for the formation and metabolism of the epoxide.

Acetates↗