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Biomedical subjects

M Nicol

Publications and source records attributed to M Nicol.

90 records · Page 5Linked to original sources
PubMedDate not supplied

Dopaminergic stimulation of cortisol secretion from bovine zfr cells occurs through nonspecific stimulation of adrenergic beta-receptors.

Previous reports have suggested a possible dopaminergic inhibition of the actions of AII on aldosterone secretion via adenylate-cyclase inhibitory 'D2' receptors. Others suggest a possible stimulation of aldosterone secretion via a stimulatory 'D1' receptor/cAMP pathway. We have examined the actions of dopamine on basal and AII-stimulated cortisol secretion by cultured bovine zfr cells. Dopamine alone caused a dose-dependent increase in cortisol secretion at doses >10(-5) M, and also enhanced steroidogenic output in response to submaximal (10(-10) M) but not maximal (10(-8) M) stimulatory doses of AII. The stimulatory action of dopamine alone on cortisol secretion was not, however, reproduced by the 'D1' agonist fenoldopam, and was fully blocked by propranolol. Dopamine had neither a stimulatory effect on basal phosphoinositol production nor an inhibitory effect on AII-stimulated phosphoinositol production. Our findings are therefore inconsistent with the activation of a 'D1' or 'D2' class receptor, and suggest the stimulation of cortisol secretion occurred nonspecifically through a beta-adrenergic receptor.

Angiotensin II↗
PubMedDate not supplied

1. Taking blood pressure.

Explore the source record for details and available documents.

Blood Pressure Determination↗
PubMedDate not supplied

[Measurement of seminal fluid 5 alpha dihydrotestosterone levels during investigations of sterility (author's transl)].

Two androgens (testosterone, 5 alpha dihydrotestosterone) were measured by radioimmunoassay in the seminal liquid. A statistic comparison of the results has been applied to samples taken from sterile men and classed chiefly according to sperm count. Different groups were explored: normospermia; oligospermia; various azoospermias. No significant differences in testosterone were found between the groups. Levels of DHT are lower in oligospermia, and much more in azoospermia. The signification of the results is discussed.

Dihydrotestosterone↗
PubMedDate not supplied

The development of a clinical skills centre.

Guidelines produced by the General Medical Council of Great Britain have emphasised the importance of the development of the skills and attitudes appropriate for a junior doctor. Medical schools are in the process of reforming their curricula accordingly. The development of these skills is made increasingly difficult by changes such as short admissions to hospital, increased care in the community, and reduced resources. This article outlines the development of a clinical skills centre as a multidisciplinary unit to improve clinical skills teaching with the aid of up-to-date technology and educational practices. By sharing our experience we aim to provide a practical guide for the development of such units in other medical and nursing colleges.

Clinical Clerkship↗