Search PubMed⌕ Search

Biomedical subjects

M Newman

Publications and source records attributed to M Newman.

180 records · Page 10Linked to original sources
PubMedDate not supplied

The development of multi-epitope vaccines: epitope identification, vaccine design and clinical evaluation.

We have developed efficient methods for epitope identification and vaccine design. Our process for epitope selection based on the combined use of motif analyses, binding assays and immunogenicity evaluations is described. We also describe how the projected population coverage and vaccine design can be optimized. Finally, it is discussed how vaccine potency is evaluated by immunogenicity and antigenicity assays.

Epitopes↗
PubMedDate not supplied

Genetic linkage between X-chromosome markers and bipolar affective illness.

A pedigree study shows close linkage of bipolar affective illness (manic depression) to the X-chromosome markers colour blindness and glucose-6-phosphate dehydrogenase deficiency. The maximum lod score ranges from 7.52 (assuming homogeneity) to 9.17 (assuming heterogeneity); that is, the odds in favour of linkage range between 3 X 10(7) to 1 and 10(9) to 1. These results provide confirmation that a major psychiatric disorder can be caused by a single genetic defect. As a possible first step in characterizing the primary genetic abnormality, this finding may have important implications for the aetiology, nosology, pathophysiology and, possibly, prevention and treatment of bipolar affective disorder. It also provides a means for identifying and characterizing homogeneous populations of patients and may help in clarifying aetiological heterogeneity.

Bipolar Disorder↗
PubMedDate not supplied

The synergy of health promotion practice/research/education.

Many nurses are concerned about the lack of connection among nursing practice, research and education. However, the assumption that nursing practice, research, and education represent separate domains or activities that need to be linked, may well contravene the relational synergy they share. This paper describes a project that sought to illustrate, and further explore, the synergistic, iterative relationship of health promoting practice/research/education. The project revealed how this synergy lives out within the daily practice of frontline practitioners and how the researched knowledge practitioners bring forth through their practice can transform care.

Asthma↗
PubMedDate not supplied

By the numbers. Care for arthritis and other chronic conditions.

This issue's "By the Numbers" highlights recent findings on care for patients with rheumatoid arthritis in HMO and fee-for-service (FFS) settings. It also looks at the prevalence of arthritis and other chronic conditions in these plans.

Activities of Daily Living↗
PubMedDate not supplied

Predicting licensure success with a computerized comprehensive nursing exam. The HESI Exit Exam.

This study was designed to determine the accuracy of computerized comprehensive nursing exams, HESI Exit Exams (E2s), in predicting registered nurse and practical nurse students success on the licensing exam. Schools of nursing that administered E2s during the academic year 1996-97 were surveyed to determine how many students (n = 2809) predicted by the E2 to pass the licensure exam had failed, and if the exam administration was monitored or proctored. Based on the findings of this study, the E2 was determined to be an accurate predictor of students' success on the licensing exam. However, it was significantly more accurate (P = .05) when the exam was monitored (99.49%) than unmonitored (96.82%). The E2 was determined to be highly predictive of students' success on the licensing exam for all groups tested: associate degree, baccalaureate, diploma, and practical nursing students.

Computer-Assisted Instruction↗
PubMedDate not supplied

Predictive accuracy of the HESI Exit Exam. A follow-up study.

This follow-up study compares the accuracy of the HESI Exit Exam (E2) in predicting NCLEX success for the academic years 1996-97 (N = 2,809) and 1997-98 (N = 3,752) and is designed to replicate the study of Lauchner et al. and to implement recommendations suggested by the authors for further research. The E2 was again found to be highly predictive of licensure success, regardless of the type of program tested: associate degree, baccalaureate degree, diploma, or practical nurse programs. The predictive accuracy of the E2 was 98.27% for the RN group and 99.34% for the PN group. The E2 was again found to be significantly more accurate when administration of the exam was monitored than when it was not monitored (P = 0.05). In the 1997-98 academic year, NCLEX success of low-scoring E2 students was examined. Significantly more (P = 0.001) of the low-scoring E2 students failed the licensure exam than high-scoring E2 students. However, significantly fewer (p = 0.05) of these low-scoring E2 students failed the licensing exam when the E2 was used as a benchmark or guide for remediation.

Chi-Square Distribution↗
PubMedDate not supplied

Chemonucleolysis.

Explore the source record for details and available documents.

Animals↗